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Ttc7b tetratricopeptide repeat domain 7B [ Mus musculus (house mouse) ]

Gene ID: 104718, updated on 5-Mar-2024

Summary

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Official Symbol
Ttc7bprovided by MGI
Official Full Name
tetratricopeptide repeat domain 7Bprovided by MGI
Primary source
MGI:MGI:2144724
See related
Ensembl:ENSMUSG00000033530 AllianceGenome:MGI:2144724
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttc7l1
Summary
Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in central nervous system; liver; and retina nuclear layer. Orthologous to human TTC7B (tetratricopeptide repeat domain 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 38.4), frontal lobe adult (RPKM 33.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 50.43 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100267029..100487134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100300770..100520837, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:101466777-101466886 Neighboring gene STARR-seq mESC enhancer starr_33040 Neighboring gene calmodulin 1 Neighboring gene predicted gene, 40557 Neighboring gene STARR-seq mESC enhancer starr_33043 Neighboring gene predicted gene 10432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:101570101-101570302 Neighboring gene STARR-seq mESC enhancer starr_33044 Neighboring gene predicted gene, 51958 Neighboring gene STARR-positive B cell enhancer ABC_E7167 Neighboring gene predicted gene, 53757 Neighboring gene predicted gene, 36375 Neighboring gene STARR-seq mESC enhancer starr_33048 Neighboring gene STARR-positive B cell enhancer ABC_E1450 Neighboring gene STARR-seq mESC enhancer starr_33055 Neighboring gene ribosomal protein S6 kinase, polypeptide 5 Neighboring gene STARR-positive B cell enhancer mm9_chr12:101842850-101843151 Neighboring gene STARR-seq mESC enhancer starr_33059 Neighboring gene STARR-positive B cell enhancer ABC_E1451 Neighboring gene STARR-positive B cell enhancer ABC_E8499 Neighboring gene predicted gene 2614

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identity. Nakatsu F, et al. J Cell Biol, 2012 Dec 10. PMID 23229899, Free PMC Article
  2. SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation. Blewitt ME, et al. Nat Genet, 2008 May. PMID 18425126
  3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 7B
Names
TPR repeat protein 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033213.2 → NP_001028385.1  tetratricopeptide repeat protein 7B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC123705, AC159633, AC160340
    Consensus CDS
    CCDS49141.1
    UniProtKB/Swiss-Prot
    E9Q6P5
    Related
    ENSMUSP00000052107.7, ENSMUST00000062957.8
    Conserved Domains (3) summary
    TIGR02917
    Location:343 → 834
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:431 → 459
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:730 → 758
    TPR; TPR repeat [structural motif]

  2. NM_001374711.1 → NP_001361640.1  tetratricopeptide repeat protein 7B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123705, AC159633, AC160340
    Consensus CDS
    CCDS88387.1
    UniProtKB/TrEMBL
    A0A1Y7VL44
    Related
    ENSMUSP00000152299.2, ENSMUST00000223020.2
    Conserved Domains (4) summary
    TIGR00990
    Location:686 → 859
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:343 → 851
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:431 → 459
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:747 → 775
    TPR; TPR repeat [structural motif]

  3. NM_001401370.1 → NP_001388299.1  tetratricopeptide repeat protein 7B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123705, AC159633, AC160340

  4. NM_001413292.1 → NP_001400221.1  tetratricopeptide repeat protein 7B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC123705, AC159633, AC160340

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100267029..100487134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515326.4 → XP_006515389.1  tetratricopeptide repeat protein 7B isoform X3

    Conserved Domains (4) summary
    COG0457
    Location:365 → 619
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:755 → 928
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:431 → 459
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:816 → 844
    TPR; TPR repeat [structural motif]

  2. XM_017314925.3 → XP_017170414.1  tetratricopeptide repeat protein 7B isoform X10

    Conserved Domains (3) summary
    TIGR02917
    Location:351 → 843
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:739 → 767
    TPR; TPR repeat [structural motif]

  3. XM_017314924.3 → XP_017170413.1  tetratricopeptide repeat protein 7B isoform X9

    Conserved Domains (3) summary
    TIGR02917
    Location:351 → 851
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:747 → 775
    TPR; TPR repeat [structural motif]

  4. XM_017314922.3 → XP_017170411.1  tetratricopeptide repeat protein 7B isoform X8

    Conserved Domains (3) summary
    TIGR02917
    Location:351 → 858
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:754 → 782
    TPR; TPR repeat [structural motif]

  5. XM_017314921.3 → XP_017170410.1  tetratricopeptide repeat protein 7B isoform X7

    Conserved Domains (4) summary
    TIGR00990
    Location:694 → 867
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:351 → 859
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:755 → 783
    TPR; TPR repeat [structural motif]

  6. XM_017314920.3 → XP_017170409.1  tetratricopeptide repeat protein 7B isoform X6

    Conserved Domains (4) summary
    TIGR00990
    Location:702 → 875
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:351 → 867
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:763 → 791
    TPR; TPR repeat [structural motif]

  7. XM_017314919.3 → XP_017170408.1  tetratricopeptide repeat protein 7B isoform X5

    Conserved Domains (4) summary
    TIGR00990
    Location:709 → 882
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:351 → 874
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:770 → 798
    TPR; TPR repeat [structural motif]

  8. XM_006515328.4 → XP_006515391.1  tetratricopeptide repeat protein 7B isoform X4

    Conserved Domains (4) summary
    TIGR00990
    Location:748 → 921
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:351 → 913
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:809 → 837
    TPR; TPR repeat [structural motif]

  9. XM_011243973.4 → XP_011242275.1  tetratricopeptide repeat protein 7B isoform X2

    Conserved Domains (4) summary
    COG0457
    Location:373 → 627
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:756 → 929
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:817 → 845
    TPR; TPR repeat [structural motif]

  10. XM_006515325.2 → XP_006515388.1  tetratricopeptide repeat protein 7B isoform X1

    Conserved Domains (4) summary
    COG0457
    Location:373 → 627
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:763 → 936
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:439 → 467
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:824 → 852
    TPR; TPR repeat [structural motif]

  11. XM_036157145.1 → XP_036013038.1  tetratricopeptide repeat protein 7B isoform X16

    Conserved Domains (4) summary
    TIGR00990
    Location:289 → 462
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    TIGR02917
    Location:24 → 454
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:51 → 79
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:350 → 378
    TPR; TPR repeat [structural motif]

  12. XM_030246492.1 → XP_030102352.1  tetratricopeptide repeat protein 7B isoform X15

    Conserved Domains (3) summary
    TIGR02917
    Location:85 → 576
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00008
    Location:173 → 201
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:472 → 500
    TPR; TPR repeat [structural motif]

  13. XM_030246491.1 → XP_030102351.1  tetratricopeptide repeat protein 7B isoform X14

    Conserved Domains (4) summary
    COG0457
    Location:107 → 361
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:497 → 670
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:173 → 201
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:558 → 586
    TPR; TPR repeat [structural motif]

  14. XM_030246490.1 → XP_030102350.1  tetratricopeptide repeat protein 7B isoform X13

    Conserved Domains (4) summary
    COG0457
    Location:263 → 517
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:653 → 826
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:329 → 357
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:714 → 742
    TPR; TPR repeat [structural motif]

  15. XM_036157144.1 → XP_036013037.1  tetratricopeptide repeat protein 7B isoform X12

    Conserved Domains (4) summary
    COG0457
    Location:271 → 525
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    TIGR00990
    Location:661 → 834
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00008
    Location:337 → 365
    TPR_YbbN; TPR repeat [structural motif]
    sd00006
    Location:722 → 750
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q6P5.1 GenPept UniProtKB/Swiss-Prot:E9Q6P5

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