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Pik3r6 phosphoinositide-3-kinase regulatory subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 104709, updated on 5-Mar-2024

Summary

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Official Symbol
Pik3r6provided by MGI
Official Full Name
phosphoinositide-3-kinase regulatory subunit 5provided by MGI
Primary source
MGI:MGI:2144613
See related
Ensembl:ENSMUSG00000046207 AllianceGenome:MGI:2144613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p84; p87PIKAP; p84 PIKAP; p87(PIKAP)
Summary
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 11. The protein binds to both the catalytic subunit and to G beta-gamma, and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in lung adult (RPKM 5.1), mammary gland adult (RPKM 3.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 41.76 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68393845..68443524)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68503019..68552698)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68245166-68245319 Neighboring gene STARR-positive B cell enhancer mm9_chr11:68245418-68245719 Neighboring gene predicted gene, 32046 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68276328-68276529 Neighboring gene STARR-positive B cell enhancer ABC_E3959 Neighboring gene STARR-positive B cell enhancer ABC_E6997 Neighboring gene STARR-seq mESC enhancer starr_29817 Neighboring gene major facilitator superfamily domain containing 6-like Neighboring gene predicted gene, 40036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. miRNA-155 controls mast cell activation by regulating the PI3Kγ pathway and anaphylaxis in a mouse model. Biethahn K, et al. Allergy, 2014 Jun. PMID 24734904
  2. Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs). Vadas O, et al. Proc Natl Acad Sci U S A, 2013 Nov 19. PMID 24190998, Free PMC Article
  3. Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ). Lee B, et al. Mol Pain, 2011 Dec 14. PMID 22168443, Free PMC Article
  4. PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells. Bohnacker T, et al. Sci Signal, 2009 Jun 9. PMID 19509406
  5. Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils. Rynkiewicz NK, et al. Sci Signal, 2020 Nov 3. PMID 33144519, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gbetagamma is a direct regulator of endogenous p101/p110gamma and p84/p110gamma PI3Kgamma complexes in mouse neutrophils.
    Title: Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils.
  2. These data demonstrate PI3Kgamma-dependent signalling downstream of IL-17RA, which plays a pivotal role in regulating IL-17 production in T cells.
    Title: Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
  3. GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
    Title: GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
  4. that genetic deletion of PI3Kgamma enhanced scratching behaviours in histamine-dependent and protease-activated receptor 2 (PAR-2)-dependent itch.
    Title: Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-γ (PI3Kγ).
  5. Results suggest that the CXCR2 and PI3Kgamma signaling pathway may represent a suitable target for the development of novel therapeutic strategies for human diseases characterized by vascular leakage.
    Title: A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.
  6. PI3Kgamma has a role in the induction of CXCR3 on T cells
    Title: PI3Kgamma (PI3Kgamma) is essential for efficient induction of CXCR3 on activated T cells.
  7. ablation of PI3Kgamma reduced SDF1alpha-induced integrin activation in human EPCs and in murine Lin(-) BM-derived progenitor cells
    Title: Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells.
  8. p87PIKAP is a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B [p87PIKAP]
    Title: Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class IA ISO
Inferred from Sequence Orthology
more info
  
part_of phosphatidylinositol 3-kinase complex, class IB IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoinositide 3-kinase regulatory subunit 6
Names
p84 PI3K adapter protein
p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein
phosphoinositide 3-kinase gamma adapter protein of 87 kDa
phosphoinositide-3-kinase, regulatory subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004435.3 → NP_001004435.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 2

    See identical proteins and their annotated locations for NP_001004435.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK153039, AY753194, BX629873, BY202586
    Consensus CDS
    CCDS24866.1
    UniProtKB/Swiss-Prot
    Q3U6Q4
    Related
    ENSMUSP00000099673.2, ENSMUST00000102613.8
    Conserved Domains (1) summary
    pfam10486
    Location:34 → 749
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  2. NM_001081566.2 → NP_001075035.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 1

    See identical proteins and their annotated locations for NP_001075035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform 1.
    Source sequence(s)
    AK153039, BX629873, BY202586
    Consensus CDS
    CCDS36186.1
    UniProtKB/Swiss-Prot
    Q3TBT5, Q3U6Q4, Q3UAY4, Q8K323
    Related
    ENSMUSP00000052522.7, ENSMUST00000060441.7
    Conserved Domains (1) summary
    pfam10486
    Location:34 → 753
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. NR_126153.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in an internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK036623, AK151178, BX629873, BY202586
    Related
    ENSMUST00000153671.8

  2. NR_126154.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses alternate splice sites in two internal exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK036623, AK151178, AK153039, AL606831, BX629873, BY202586

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68393845..68443524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314217.2 → XP_017169706.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

    Conserved Domains (1) summary
    pfam10486
    Location:32 → 546
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  2. XM_006531950.1 → XP_006532013.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

    Conserved Domains (1) summary
    pfam10486
    Location:32 → 499
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  3. XM_006531948.1 → XP_006532011.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

    Conserved Domains (1) summary
    pfam10486
    Location:38 → 716
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

  4. XM_030245460.1 → XP_030101320.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

    Conserved Domains (1) summary
    pfam10486
    Location:35 → 394
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. XR_001779856.2 RNA Sequence

  2. XR_003949212.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U6Q4.1 GenPept UniProtKB/Swiss-Prot:Q3U6Q4

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