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Slc16a6 solute carrier family 16 (monocarboxylic acid transporters), member 6 [ Mus musculus (house mouse) ]

Gene ID: 104681, updated on 11-Apr-2024

Summary

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Official Symbol
Slc16a6provided by MGI
Official Full Name
solute carrier family 16 (monocarboxylic acid transporters), member 6provided by MGI
Primary source
MGI:MGI:2144585
See related
Ensembl:ENSMUSG00000041920 AllianceGenome:MGI:2144585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MCT6; MCT 6; MCT 7; ESTM12
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; integumental system; liver; retina; and urinary system. Orthologous to human SLC16A6 (solute carrier family 16 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 4.3), liver E14 (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E1; 11 71.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109341681..109366428, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109450855..109473598, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7086 Neighboring gene STARR-positive B cell enhancer ABC_E5291 Neighboring gene predicted gene 11696 Neighboring gene guanine nucleotide binding protein, alpha 13 Neighboring gene STARR-positive B cell enhancer ABC_E4009 Neighboring gene STARR-positive B cell enhancer ABC_E7087 Neighboring gene STARR-positive B cell enhancer mm9_chr11:109281499-109281800 Neighboring gene STARR-positive B cell enhancer ABC_E380 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109287298-109287521 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109293875-109294028 Neighboring gene STARR-positive B cell enhancer ABC_E10727 Neighboring gene STARR-positive B cell enhancer ABC_E5293 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene predicted gene, 45916 Neighboring gene STARR-positive B cell enhancer ABC_E5294 Neighboring gene STARR-positive B cell enhancer ABC_E7088 Neighboring gene STARR-positive B cell enhancer ABC_E1846 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:109357315-109357468 Neighboring gene arylsulfatase G Neighboring gene predicted gene, 22378 Neighboring gene STARR-positive B cell enhancer ABC_E7089 Neighboring gene predicted gene, 39442 Neighboring gene WD repeat domain, phosphoinositide interacting 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism. Jones RS, et al. Mol Pharmacol, 2019 Sep. PMID 31436537, Free PMC Article
  2. Functional analysis of candidate genes from genome-wide association studies of hearing. Ingham NJ, et al. Hear Res, 2020 Mar 1. PMID 31927188, Free PMC Article
  3. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results from the knockout (KO) mouse model of Mct6 deficiency support the importance of MCT6 in regulating a variety of glucose and lipid metabolic pathways, which may indicate its significance in metabolic diseases.
    Title: Characterization and Proteomic-Transcriptomic Investigation of Monocarboxylate Transporter 6 Knockout Mice: Evidence of a Potential Role in Glucose and Lipid Metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27628

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taurine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monocarboxylic acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 7
Names
monocarboxylate transporter 6
solute carrier family 16 member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029842.3 → NP_001025013.2  monocarboxylate transporter 7 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL645791
    Consensus CDS
    CCDS25580.1
    Related
    ENSMUSP00000065628.6, ENSMUST00000070152.12

  2. NM_001363364.2 → NP_001350293.1  monocarboxylate transporter 7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL645791
    UniProtKB/Swiss-Prot
    B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
    Conserved Domains (1) summary
    cd17422
    Location:40 → 488
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  3. NM_134038.4 → NP_598799.1  monocarboxylate transporter 7 isoform b

    See identical proteins and their annotated locations for NP_598799.1

    Status: VALIDATED

    Source sequence(s)
    AL645791
    Consensus CDS
    CCDS36360.1
    UniProtKB/Swiss-Prot
    B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
    Related
    ENSMUSP00000067423.7, ENSMUST00000070872.13
    Conserved Domains (1) summary
    cd17422
    Location:24 → 472
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    109341681..109366428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156212.1 → XP_036012105.1  monocarboxylate transporter 7 isoform X4

    UniProtKB/Swiss-Prot
    B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
    Conserved Domains (1) summary
    cl28910
    Location:108 → 465
    MFS; Major Facilitator Superfamily

  2. XM_036156210.1 → XP_036012103.1  monocarboxylate transporter 7 isoform X1

    UniProtKB/Swiss-Prot
    B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
    Conserved Domains (1) summary
    cd17422
    Location:108 → 508
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  3. XM_017314216.3 → XP_017169705.1  monocarboxylate transporter 7 isoform X2

    UniProtKB/Swiss-Prot
    B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
    Conserved Domains (1) summary
    cd17422
    Location:40 → 488
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  4. XM_036156214.1 → XP_036012107.1  monocarboxylate transporter 7 isoform X5

    Conserved Domains (1) summary
    cd17422
    Location:24 → 424
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  5. XM_036156211.1 → XP_036012104.1  monocarboxylate transporter 7 isoform X3

    UniProtKB/Swiss-Prot
    B1AT66, D3Z3P6, E9Q5J8, Q3TCY8, Q8C086, Q91W47
    Conserved Domains (1) summary
    cd17422
    Location:24 → 472
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  6. XM_036156213.1 → XP_036012106.1  monocarboxylate transporter 7 isoform X5

    Conserved Domains (1) summary
    cd17422
    Location:24 → 424
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1AT66.1 GenPept UniProtKB/Swiss-Prot:B1AT66

Gene LinkOut

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