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ZNHIT1 zinc finger HIT-type containing 1 [ Homo sapiens (human) ]

Gene ID: 10467, updated on 3-Apr-2024

Summary

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Official Symbol
ZNHIT1provided by HGNC
Official Full Name
zinc finger HIT-type containing 1provided by HGNC
Primary source
HGNC:HGNC:21688
See related
Ensembl:ENSG00000106400 MIM:618617; AllianceGenome:HGNC:21688
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG1I; ZNFN4A1; p18(Hamlet)
Summary
Predicted to enable histone deacetylase binding activity and nucleosome binding activity. Predicted to be involved in histone exchange. Predicted to act upstream of or within several processes, including negative regulation of G0 to G1 transition; negative regulation of transcription by RNA polymerase II; and regulation of histone deacetylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 23.5), kidney (RPKM 21.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101218165..101224190)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102541627..102547653)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100861446..100867471)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100846277-100847083 Neighboring gene ribosomal protein SA pseudogene 46 Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100859968-100860490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100861252-100861793 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100870334-100870510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100874831-100875752 Neighboring gene claudin 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100883201-100883744 Neighboring gene fission, mitochondrial 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26403

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A combined proteomics and bioinformatics analysis of ZNHIT1-interacting proteins reveals a significant enrichment in proteins associated with mitochondrial function. Anantha J, et al. J Chem Neuroanat, 2023 Sep. PMID 37178741
  2. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells. McCarthy E, et al. Mol Neurobiol, 2022 May. PMID 35175558, Free PMC Article
  3. Znhit1 and HIF-2α are correlated with cancer stem cell markers in breast cancer patients. Ebeid SA, et al. Sci Rep, 2022 Aug 17. PMID 35978075, Free PMC Article
  4. p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents. Lafarga V, et al. Cell Cycle, 2007 Oct 1. PMID 17700068
  5. A zinc finger HIT domain-containing protein, ZNHIT-1, interacts with orphan nuclear hormone receptor Rev-erbbeta and removes Rev-erbbeta-induced inhibition of apoCIII transcription. Wang J, et al. FEBS J, 2007 Oct. PMID 17892483

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A combined proteomics and bioinformatics analysis of ZNHIT1-interacting proteins reveals a significant enrichment in proteins associated with mitochondrial function.
    Title: A combined proteomics and bioinformatics analysis of ZNHIT1-interacting proteins reveals a significant enrichment in proteins associated with mitochondrial function.
  2. Znhit1 and HIF-2alpha are correlated with cancer stem cell markers in breast cancer patients.
    Title: Znhit1 and HIF-2α are correlated with cancer stem cell markers in breast cancer patients.
  3. Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against alpha-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells.
    Title: Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells.
  4. Study reports that p18(Hamlet) can also mediate the cell cycle arrest induced in response to gamma-irradiation, by participating in the p53-dependent upregulation of the cell cycle inhibitor p21(Cip1) (CDKN1A).
    Title: p18(Hamlet) mediates different p53-dependent responses to DNA-damage inducing agents.
  5. p18(Hamlet) is a new cell-fate regulator that links the p38 MAPK and p53 pathways and contributes to the establishment of p53-regulated stress responses.
    Title: A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in heart process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intestinal stem cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lymphoid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Swr1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
part_of nucleosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger HIT domain-containing protein 1
Names
H_DJ0747G18.14
cyclin-G1-binding protein 1
p18 Hamlet
p18Hamlet
putative cyclin G1 interacting protein
zinc finger protein subfamily 4A member 1
zinc finger protein, subfamily 4A (HIT domain containing), member 1
zinc finger, HIT domain containing 1
zinc finger, HIT type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006349.3 → NP_006340.1  zinc finger HIT domain-containing protein 1

    See identical proteins and their annotated locations for NP_006340.1

    Status: VALIDATED

    Source sequence(s)
    BC001877, BC017333
    Consensus CDS
    CCDS5716.1
    UniProtKB/Swiss-Prot
    O43257, Q6IB12
    UniProtKB/TrEMBL
    B2R5C5
    Related
    ENSP00000304593.2, ENST00000305105.3
    Conserved Domains (2) summary
    pfam04438
    Location:113 → 140
    zf-HIT; HIT zinc finger
    cl02154
    Location:75 → 135
    YL1_C; YL1 nuclear protein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101218165..101224190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515739.3 → XP_011514041.1  zinc finger HIT domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    B2R5C5
    Conserved Domains (2) summary
    pfam04438
    Location:128 → 155
    zf-HIT; HIT zinc finger
    cl02154
    Location:90 → 150
    YL1_C; YL1 nuclear protein C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102541627..102547653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357091.1 → XP_054213066.1  zinc finger HIT domain-containing protein 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43257.1 GenPept UniProtKB/Swiss-Prot:O43257

Gene LinkOut

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