U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PIBF1 progesterone immunomodulatory binding factor 1 [ Homo sapiens (human) ]

Gene ID: 10464, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PIBF1provided by HGNC
Official Full Name
progesterone immunomodulatory binding factor 1provided by HGNC
Primary source
HGNC:HGNC:23352
See related
Ensembl:ENSG00000083535 MIM:607532; AllianceGenome:HGNC:23352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIBF; CEP90; JBTS33; C13orf24
Summary
This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 8.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PIBF1 in Genome Data Viewer
Location:
13q21.33-q22.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (72782133..73016461)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (72003616..72238006)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (73356271..73590599)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73301228-73301409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7814 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:73355230-73356144 Neighboring gene DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73426017-73426548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:73426549-73427078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7816 Neighboring gene RNA, U6 small nuclear 79, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr13:73509249-73509443 Neighboring gene NANOG hESC enhancer GRCh37_chr13:73534622-73535123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73610339-73611015 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:73612066-73612896 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5397 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5398 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73648866-73649672 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:73649673-73650478 Neighboring gene KLF transcription factor 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Biologia futura: embryo-maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation. Szekeres-Bartho J, et al. Biol Futur, 2021 Mar. PMID 34554496
  2. Progesterone-induced blocking factor (PIBF) influences the expression of membrane progesterone receptors (mPRs) on peripheral CD4(+) T lymphocyte cells in normal fertile females. Rafiee M, et al. Hormones (Athens), 2021 Sep. PMID 33914290
  3. Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women. Lim MK, et al. Sci Rep, 2020 Mar 2. PMID 32123187, Free PMC Article
  4. High Immune Expression of Progesterone-Induced Blocking Factor in Epithelial Ovarian Cancer. Madendag Y, et al. Technol Cancer Res Treat, 2018 Jan 1. PMID 29962287, Free PMC Article
  5. Proliferative and Invasive Effects of Progesterone-Induced Blocking Factor in Human Glioblastoma Cells. Gutiérrez-Rodríguez A, et al. Biomed Res Int, 2017. PMID 28168193, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells.
    Title: PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells.
  2. PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
    Title: PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development.
  3. Progesterone-induced blocking factor (PIBF) influences the expression of membrane progesterone receptors (mPRs) on peripheral CD4(+) T lymphocyte cells in normal fertile females.
    Title: Progesterone-induced blocking factor (PIBF) influences the expression of membrane progesterone receptors (mPRs) on peripheral CD4(+) T lymphocyte cells in normal fertile females.
  4. Biologia futura: embryo-maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation.
    Title: Biologia futura: embryo-maternal communication via progesterone-induced blocking factor (PIBF) positive embryo-derived extracellular vesicles. Their role in maternal immunomodulation.
  5. A ciliopathy complex builds distal appendages to initiate ciliogenesis.
    Title: A ciliopathy complex builds distal appendages to initiate ciliogenesis.
  6. PIBF1 suppresses the ATR/CHK1 signaling pathway and promotes proliferation and motility of triple-negative breast cancer cells.
    Title: PIBF1 suppresses the ATR/CHK1 signaling pathway and promotes proliferation and motility of triple-negative breast cancer cells.
  7. Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women.
    Title: Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women.
  8. In conditioned media of PIBF-deficient JEG-3 cells, primary lung and ovarian cancer cells MMP9 activity was reduced. PIBF silencing resulted in increased E-cadherin expression, suggesting that by down regulating E-cadherin expression, PIBF might interfere with the cell-cell adhesion mechanisms and by increasing MMP activity induced extracellular matrix degradation, facilitates the invasion of tumor cells.
    Title: The effect of the Progesterone-Induced Blocking Factor (PIBF) on E-cadherin expression, cell motility and invasion of primary tumour cell lines.
  9. We found at high levels of expression of PIBF protein in epithelial ovarian cancer patients. These data demonstrate that tumor cells can secrete PIBF to escape the immune system
    Title: High Immune Expression of Progesterone-Induced Blocking Factor in Epithelial Ovarian Cancer.
  10. blood and placental tissue level expression of PIBF is concordant and correlates with both progesterone receptor expression status as well as final pregnancy outcome
    Title: Preterm delivery and associated negative pregnancy outcome - A tale of faulty progesterone receptor signalling pathway and linked derailed immunomodulation: A study from Northeast India.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Joubert syndrome 33
MedGen: C4540389 OMIM: 617767 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1008

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-4 receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of Janus kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of natural killer cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
progesterone-induced-blocking factor 1
Names
centrosomal protein of 90 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053118.2 RefSeqGene

    Range
    5002..239330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001349655.2 → NP_001336584.1  progesterone-induced-blocking factor 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL354720, AL391384
    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (1) summary
    cl25732
    Location:81 → 721
    SMC_N; RecF/RecN/SMC N terminal domain

  2. NM_006346.4 → NP_006337.2  progesterone-induced-blocking factor 1 isoform 2

    See identical proteins and their annotated locations for NP_006337.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AL354720, AL391384
    Consensus CDS
    CCDS31991.1
    UniProtKB/Swiss-Prot
    O95664, Q6U9V2, Q6UG50, Q86V07, Q8WXW3, Q96SF4
    UniProtKB/TrEMBL
    A0A087WUI6
    Related
    ENSP00000317144.6, ENST00000326291.11
    Conserved Domains (3) summary
    COG0497
    Location:468 → 698
    RecN; DNA repair ATPase RecN [Replication, recombination and repair]
    TIGR02168
    Location:208 → 538
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:32 → 355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RNA

  1. NR_146205.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon compared to variant 1.
    Source sequence(s)
    AL354720, AL391384

  2. NR_146206.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks two exons compared to variant 1.
    Source sequence(s)
    AL354720, AL391384

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    72782133..73016461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534882.4 → XP_011533184.1  progesterone-induced-blocking factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (2) summary
    TIGR02168
    Location:208 → 567
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:32 → 355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_024449314.2 → XP_024305082.1  progesterone-induced-blocking factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (1) summary
    cl25732
    Location:208 → 538
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_011534885.4 → XP_011533187.1  progesterone-induced-blocking factor 1 isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:85 → 444
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_047430045.1 → XP_047286001.1  progesterone-induced-blocking factor 1 isoform X2

  5. XM_047430047.1 → XP_047286003.1  progesterone-induced-blocking factor 1 isoform X6

    Related
    ENSP00000478697.1, ENST00000617689.4

  6. XM_047430046.1 → XP_047286002.1  progesterone-induced-blocking factor 1 isoform X4

  7. XM_047430048.1 → XP_047286004.1  progesterone-induced-blocking factor 1 isoform X8

  8. XM_011534884.4 → XP_011533186.1  progesterone-induced-blocking factor 1 isoform X7

    UniProtKB/TrEMBL
    A0A087WUI6
    Conserved Domains (2) summary
    TIGR02168
    Location:208 → 567
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    TIGR02169
    Location:32 → 355
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  9. XM_047430049.1 → XP_047286005.1  progesterone-induced-blocking factor 1 isoform X9

  10. XM_017020351.2 → XP_016875840.1  progesterone-induced-blocking factor 1 isoform X10

  11. XM_011534886.4 → XP_011533188.1  progesterone-induced-blocking factor 1 isoform X11

    UniProtKB/TrEMBL
    Q05DN0
    Conserved Domains (1) summary
    COG1196
    Location:36 → 357
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_047430050.1 → XP_047286006.1  progesterone-induced-blocking factor 1 isoform X12

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    72003616..72238006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374017.1 → XP_054229992.1  progesterone-induced-blocking factor 1 isoform X1

  2. XM_054374019.1 → XP_054229994.1  progesterone-induced-blocking factor 1 isoform X3

  3. XM_054374021.1 → XP_054229996.1  progesterone-induced-blocking factor 1 isoform X5

  4. XM_054374018.1 → XP_054229993.1  progesterone-induced-blocking factor 1 isoform X2

  5. XM_054374022.1 → XP_054229997.1  progesterone-induced-blocking factor 1 isoform X6

  6. XM_054374020.1 → XP_054229995.1  progesterone-induced-blocking factor 1 isoform X4

  7. XM_054374024.1 → XP_054229999.1  progesterone-induced-blocking factor 1 isoform X8

  8. XM_054374023.1 → XP_054229998.1  progesterone-induced-blocking factor 1 isoform X7

  9. XM_054374025.1 → XP_054230000.1  progesterone-induced-blocking factor 1 isoform X9

  10. XM_054374026.1 → XP_054230001.1  progesterone-induced-blocking factor 1 isoform X10

  11. XM_054374028.1 → XP_054230003.1  progesterone-induced-blocking factor 1 isoform X12

  12. XM_054374027.1 → XP_054230002.1  progesterone-induced-blocking factor 1 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXW3.2 GenPept UniProtKB/Swiss-Prot:Q8WXW3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous