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Cnot6 CCR4-NOT transcription complex, subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 104625, updated on 8-May-2024

Summary

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Official Symbol
Cnot6provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 6provided by MGI
Primary source
MGI:MGI:2144529
See related
Ensembl:ENSMUSG00000020362 AllianceGenome:MGI:2144529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCR4
Summary
Predicted to enable nuclear receptor coactivator activity and poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process; positive regulation of cell population proliferation; and positive regulation of cytoplasmic mRNA processing body assembly. Predicted to act upstream of or within gene silencing by RNA and regulation of translation. Predicted to be part of CCR4-NOT complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human CNOT6 (CCR4-NOT transcription complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 21.1), limb E14.5 (RPKM 17.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.2; 11 29.76 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49562324..49604227, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49671497..49713401, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene FMS-like tyrosine kinase 4 Neighboring gene STARR-seq mESC enhancer starr_29379 Neighboring gene secretoglobin, family 3A, member 1 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9822 Neighboring gene predicted gene 12192 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49538288-49538489 Neighboring gene predicted gene, 36411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49578193-49578302 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:49585761-49585914 Neighboring gene STARR-seq mESC enhancer starr_29382 Neighboring gene predicted gene, 36507 Neighboring gene glutamine fructose-6-phosphate transaminase 2 Neighboring gene STARR-seq mESC enhancer starr_29384

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CNOT6 regulates a novel pattern of mRNA deadenylation during oocyte meiotic maturation. Vieux KF, et al. Sci Rep, 2018 May 1. PMID 29717177, Free PMC Article
  2. CNOT6/6L-mediated mRNA degradation in ovarian granulosa cells is a key mechanism of gonadotropin-triggered follicle development. Dai XX, et al. Cell Rep, 2021 Nov 16. PMID 34788619
  3. CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte. Sha QQ, et al. EMBO J, 2018 Dec 14. PMID 30478191, Free PMC Article
  4. Cnot8 eliminates naïve regulation networks and is essential for naïve-to-formative pluripotency transition. Quan Y, et al. Nucleic Acids Res, 2022 May 6. PMID 35390160, Free PMC Article
  5. Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability. Mostafa D, et al. RNA Biol, 2020 Mar. PMID 31924127, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC98472, A230103N10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(A)-specific ribonuclease activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 6
Names
carbon catabolite repressor protein 4 homolog
cytoplasmic deadenylase
NP_001277670.1
NP_001350285.1
NP_001350286.1
NP_997649.1
XP_006532004.1
XP_006532005.1
XP_017169703.1
XP_036012101.1
XP_036012102.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290741.2 → NP_001277670.1  CCR4-NOT transcription complex subunit 6 isoform 1

    See identical proteins and their annotated locations for NP_001277670.1

    Status: VALIDATED

    Source sequence(s)
    AK039164, AL606479, BB402523, BC062950, CF746424
    Consensus CDS
    CCDS70172.1
    UniProtKB/Swiss-Prot
    Q5NCL3, Q80V15, Q8K3P5
    Related
    ENSMUSP00000121239.2, ENSMUST00000145353.8
    Conserved Domains (3) summary
    cd10313
    Location:191 → 540
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52 → 159
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]

  2. NM_001363356.1 → NP_001350285.1  CCR4-NOT transcription complex subunit 6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL606479
    Conserved Domains (3) summary
    cd10313
    Location:191 → 540
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52 → 158
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]

  3. NM_001363357.1 → NP_001350286.1  CCR4-NOT transcription complex subunit 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL606479
    Conserved Domains (3) summary
    cd10313
    Location:91 → 440
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    sd00031
    Location:4 → 26
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:3 → 44
    LRR_4; Leucine Rich repeats (2 copies)

  4. NM_212484.2 → NP_997649.1  CCR4-NOT transcription complex subunit 6 isoform 2

    See identical proteins and their annotated locations for NP_997649.1

    Status: VALIDATED

    Source sequence(s)
    AK039164, BB402523, BC062950, BY741392
    Consensus CDS
    CCDS24621.1
    UniProtKB/Swiss-Prot
    Q8K3P5
    Related
    ENSMUSP00000020624.7, ENSMUST00000020624.7
    Conserved Domains (3) summary
    COG4886
    Location:52 → 158
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
    cl00490
    Location:186 → 535
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    49562324..49604227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531942.3 → XP_006532005.1  CCR4-NOT transcription complex subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_006532005.1

    UniProtKB/Swiss-Prot
    Q5NCL3, Q80V15, Q8K3P5
    Conserved Domains (3) summary
    cd10313
    Location:191 → 540
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52 → 159
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]

  2. XM_017314214.3 → XP_017169703.1  CCR4-NOT transcription complex subunit 6 isoform X3

    Conserved Domains (3) summary
    cd10313
    Location:96 → 445
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    sd00031
    Location:4 → 26
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:3 → 44
    LRR_4; Leucine Rich repeats (2 copies)

  3. XM_036156209.1 → XP_036012102.1  CCR4-NOT transcription complex subunit 6 isoform X2

    Conserved Domains (3) summary
    COG4886
    Location:52 → 158
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
    cl00490
    Location:186 → 535
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. XM_006531941.5 → XP_006532004.1  CCR4-NOT transcription complex subunit 6 isoform X1

    See identical proteins and their annotated locations for XP_006532004.1

    UniProtKB/Swiss-Prot
    Q5NCL3, Q80V15, Q8K3P5
    Conserved Domains (3) summary
    cd10313
    Location:191 → 540
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52 → 159
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]

  5. XM_036156208.1 → XP_036012101.1  CCR4-NOT transcription complex subunit 6 isoform X1

    UniProtKB/Swiss-Prot
    Q5NCL3, Q80V15, Q8K3P5
    Conserved Domains (3) summary
    cd10313
    Location:191 → 540
    Deadenylase_CCR4a; C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
    COG4886
    Location:52 → 159
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3P5.2 GenPept UniProtKB/Swiss-Prot:Q8K3P5

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