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Zfp119a zinc finger protein 119a [ Mus musculus (house mouse) ]

Gene ID: 104349, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp119aprovided by MGI
Official Full Name
zinc finger protein 119aprovided by MGI
Primary source
MGI:MGI:1345189
See related
Ensembl:ENSMUSG00000057835 AllianceGenome:MGI:1345189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mzf13; Zfp119
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in alimentary system; bone; brain; and genitourinary system. Orthologous to human ZNF101 (zinc finger protein 101) and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 1.2), bladder adult (RPKM 1.2) and 28 other tissues See more
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Genomic context

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Location:
17 D; 17 29.04 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56171892..56185953, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55864886..55879457, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E4 Neighboring gene high mobility group box 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42870 Neighboring gene STARR-seq mESC enhancer starr_42871 Neighboring gene vomeronasal 2, receptor 121 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42872 Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes. Mark C, et al. DNA Cell Biol, 1999 May. PMID 10360839
  2. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. Khetchoumian K, et al. J Biol Chem, 2004 Nov 12. PMID 15322135
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 119a
Names
KRAB zinc finger protein
zinc finger protein 119

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410266.1 → NP_001397195.1  zinc finger protein 119a isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT573084

  2. NM_001410267.1 → NP_001397196.1  zinc finger protein 119a isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT573084

  3. NM_001410268.1 → NP_001397197.1  zinc finger protein 119a isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT573084

  4. NM_001410269.1 → NP_001397198.1  zinc finger protein 119a isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT573084

  5. NM_001410270.1 → NP_001397199.1  zinc finger protein 119a isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT573084

  6. NM_001410271.1 → NP_001397200.1  zinc finger protein 119a isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT573084

  7. NM_001410272.1 → NP_001397201.1  zinc finger protein 119a isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT573084

  8. NM_144546.6 → NP_653129.1  zinc finger protein 119a isoform 1

    See identical proteins and their annotated locations for NP_653129.1

    Status: VALIDATED

    Source sequence(s)
    BC118950, CT573084
    Consensus CDS
    CCDS37656.1
    UniProtKB/TrEMBL
    Q9JIC0
    Conserved Domains (5) summary
    smart00349
    Location:4 → 46
    KRAB; krueppel associated box
    COG5048
    Location:254 → 448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 41
    KRAB; KRAB box
    pfam13465
    Location:331 → 356
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56171892..56185953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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