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Zfp120 zinc finger protein 120 [ Mus musculus (house mouse) ]

Gene ID: 104348, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp120provided by MGI
Official Full Name
zinc finger protein 120provided by MGI
Primary source
MGI:MGI:1345179
See related
Ensembl:ENSMUSG00000068134 AllianceGenome:MGI:1345179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F80; MZF31; Zfp844; E030042N05Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in eye and genitourinary system. Orthologous to human ZNF101 (zinc finger protein 101) and ZNF699 (zinc finger protein 699). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 1.4), CNS E18 (RPKM 1.2) and 24 other tissues See more
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Genomic context

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Location:
2 G3; 2 74.0 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (149956327..149978598, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150114407..150136678, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene synapse differentiation inducing 1 Neighboring gene sal-like 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_05993 Neighboring gene STARR-seq mESC enhancer starr_05996 Neighboring gene STARR-seq mESC enhancer starr_05997 Neighboring gene REX4, RNA exonuclease 4 homolog pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1011 Neighboring gene predicted gene 10770 Neighboring gene predicted gene, 52531 Neighboring gene zinc finger protein 1004

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes. Mark C, et al. DNA Cell Biol, 1999 May. PMID 10360839
  2. Strain survey and genetic analysis of vasoreactivity in mouse aorta. Kim SK, et al. Physiol Genomics, 2016 Nov 1. PMID 27764765, Free PMC Article
  3. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 120
Names
zinc finger protein 31
zinc finger protein 844

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023266.4 → NP_075755.4  zinc finger protein 120 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AF211869, AK033399, AK132318
    Consensus CDS
    CCDS38264.1
    UniProtKB/TrEMBL
    A2ANU5, Q9EQK2
    Related
    ENSMUSP00000105557.2, ENSMUST00000109931.8
    Conserved Domains (2) summary
    smart00349
    Location:28 → 68
    KRAB; krueppel associated box
    pfam01352
    Location:28 → 67
    KRAB; KRAB box

  2. NM_181266.2 → NP_851783.2  zinc finger protein 120 isoform 1 precursor

    See identical proteins and their annotated locations for NP_851783.2

    Status: VALIDATED

    Source sequence(s)
    AK033399, AK132318
    Consensus CDS
    CCDS38263.1
    UniProtKB/Swiss-Prot
    Q78JR8, Q8BZW4, Q9EQK4, Q9JIB8
    Related
    ENSMUSP00000086615.7, ENSMUST00000089207.13
    Conserved Domains (5) summary
    smart00349
    Location:28 → 69
    KRAB; krueppel associated box
    COG5048
    Location:140 → 387
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298 → 318
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:28 → 67
    KRAB; KRAB box
    pfam13465
    Location:338 → 363
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    149956327..149978598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181267.2: Suppressed sequence

    Description
    NM_181267.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZW4.1 GenPept UniProtKB/Swiss-Prot:Q8BZW4

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