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Arl1 ADP-ribosylation factor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 104303, updated on 5-Mar-2024

Summary

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Official Symbol
Arl1provided by MGI
Official Full Name
ADP-ribosylation factor-like 1provided by MGI
Primary source
MGI:MGI:99436
See related
Ensembl:ENSMUSG00000060904 AllianceGenome:MGI:99436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310008D22Rik
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and enzyme activator activity. Predicted to be involved in several processes, including activation of phospholipase D activity; protein localization to Golgi apparatus; and retrograde transport, endosome to Golgi. Located in cytoplasm. Is expressed in genitourinary system and inner ear. Orthologous to human ARL1 (ADP ribosylation factor like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 60.6), placenta adult (RPKM 54.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 44.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88566720..88579956)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88730920..88744094)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Spi-C transcription factor (Spi-1/PU.1 related) Neighboring gene STARR-seq mESC enhancer starr_27509 Neighboring gene predicted gene, 46192 Neighboring gene STARR-positive B cell enhancer ABC_E11454 Neighboring gene predicted gene 4925 Neighboring gene UTP20 small subunit processome component Neighboring gene STARR-seq mESC enhancer starr_27512 Neighboring gene STARR-seq mESC enhancer starr_27513 Neighboring gene solute carrier family 5 (iodide transporter), member 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells. Zahn C, et al. Mol Membr Biol, 2006 Nov-Dec. PMID 17127620
  2. ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli. Lin CY, et al. J Biol Chem, 2000 Dec 1. PMID 10980193
  3. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
  4. ADP-ribosylation factor-like GTPase ARFRP1 is required for trans-Golgi to plasma membrane trafficking of E-cadherin. Zahn C, et al. J Biol Chem, 2008 Oct 3. PMID 18662990
  5. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest that lethality of Arfrp1 knockout embryos is due to a specific disruption of protein targeting, e.g., of ARL1 and Golgin-245, to the Golgi.
    Title: Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase D activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in toxin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 1
Names
ADP-ribosylation-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025859.3 → NP_080135.2  ADP-ribosylation factor-like protein 1

    See identical proteins and their annotated locations for NP_080135.2

    Status: PROVISIONAL

    Source sequence(s)
    AK010732
    Consensus CDS
    CCDS36025.1
    UniProtKB/Swiss-Prot
    P41276, P61211
    UniProtKB/TrEMBL
    Q14AC7, Q3TIR2, Q9D7H9
    Related
    ENSMUSP00000111942.3, ENSMUST00000116234.9
    Conserved Domains (1) summary
    cd04151
    Location:19 → 176
    Arl1; ADP ribosylation factor 1 (Arf1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88566720..88579956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244800.2 → XP_030100660.1  ADP-ribosylation factor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P41276, P61211
    UniProtKB/TrEMBL
    Q14AC7, Q3TIR2, Q9D7H9
    Conserved Domains (1) summary
    cd04151
    Location:19 → 176
    Arl1; ADP ribosylation factor 1 (Arf1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61211.1 GenPept UniProtKB/Swiss-Prot:P61211

Gene LinkOut

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