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ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 10425, updated on 3-Apr-2024

Summary

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Official Symbol
ARIH2provided by HGNC
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:690
See related
Ensembl:ENSG00000177479 MIM:605615; AllianceGenome:HGNC:690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARI2; TRIAD1
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3p21.31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48918842..48986382)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48947848..49014431)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48956275..49023815)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14340 Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14341 Neighboring gene hESC enhancers GRCh37_chr3:48955152-48955902 and GRCh37_chr3:48955903-48956654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48956655-48957405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48959089-48959589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48961592-48962092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48962093-48962593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19846 Neighboring gene ARIH2 opposite strand lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19847 Neighboring gene MPRA-validated peak4646 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:49000975-49001622 Neighboring gene uncharacterized LOC124909376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49026394-49026957 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49026958-49027520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49028085-49028646 Neighboring gene uncharacterized LOC124906235 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49043602-49044590 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49051026-49051863 Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia. Wang H, et al. Oncogene, 2018 May. PMID 29459712, Free PMC Article
  2. ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination. Geng S, et al. Cell Death Dis, 2022 Jun 22. PMID 35732617, Free PMC Article
  3. TRIAD1 is negatively regulated by the MDM2 E3 ligase. Bae S, et al. Oncol Rep, 2012 Nov. PMID 22940738
  4. Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1. Marteijn JA, et al. Blood, 2007 Nov 1. PMID 17646546
  5. ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages. Kawashima A, et al. J Immunol, 2017 Nov 15. PMID 29021376

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
    Title: ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
  2. Here, using a quantitative proteomics approach, the authors identify the E3 ligase ARIH2 as a regulator of the HIV-1 Vif protein-dependent CRL5-mediated APOBEC3 degradation. The CUL5(Vif/CBFss) complex recruits ARIH2 where it acts to transfer ubiquitin directly to the APOBEC3 targets.
    Title: ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
  3. ubiquitin-associated (UBA) domain-containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain.
    Title: Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.
  4. Data found Mll-Ell increases Triad1 in a Hox-dependent manner. Triad1 antagonizes Mll-Ell-induced protein ubiquitination and progression to AML. Triad1 knockdown significantly shortened the latency to development of AML in mice transplanted with Mll-Ell-transduced bone marrow. Further results identify Triad1 as a leukemia suppressor in 11q23-AML.
    Title: The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.
  5. these findings reveal a novel mechanism of ubiquitination-dependent negative regulation of the NLRP3 inflammasome by ARIH2 and highlight ARIH2 as a potential therapeutic target for inflammatory diseases
    Title: ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
  6. We show that ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation
    Title: A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration.
  7. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
    Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
  8. study demonstrated that TRIAD1 is a ubiquitination target for proteasome-dependent degradation by MDM2; results suggest TRIAD1 degradation by MDM2 suppresses TRIAD1-mediated cell growth; data suggested a novel negative regulatory mechanism of TRIAD1 via MDM2 E3 ligase ubiquitination
    Title: TRIAD1 is negatively regulated by the MDM2 E3 ligase.
  9. TRIAD1 as a novel modulator of the p53-MDM2 axis that induces p53 activation by inhibiting its regulation by MDM2.
    Title: TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.
  10. In sharp contrast to SIAH1/SIAH2 and UBCH8, TRIAD1 binding to PML-RARalpha has no effect on its turnover.
    Title: Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ10938, FLJ33921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in developmental cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARIH2
Names
RING-type E3 ubiquitin transferase ARIH2
all-trans retinoic acid inducible RING finger
ariadne homolog 2
protein ariadne-2 homolog
NP_001304262.1
NP_001304263.1
NP_001336138.1
NP_001336139.1
NP_001336140.1
NP_001336141.1
NP_001336142.1
NP_001336143.1
NP_001336144.1
NP_001336145.1
NP_001336146.1
NP_001336147.1
NP_001336148.1
NP_001336149.1
NP_001336150.1
NP_001336151.1
NP_001336152.1
NP_001336153.1
NP_001336154.1
NP_001336155.1
NP_001336156.1
NP_001336157.1
NP_001336158.1
NP_001336159.1
NP_006312.1
XP_011531570.1
XP_011531573.1
XP_016861023.1
XP_016861024.1
XP_024309077.1
XP_024309079.1
XP_047303221.1
XP_047303223.1
XP_047303234.1
XP_047303239.1
XP_047303240.1
XP_054200902.1
XP_054200903.1
XP_054200904.1
XP_054200905.1
XP_054200906.1
XP_054200907.1
XP_054200908.1
XP_054200909.1
XP_054200910.1
XP_054200911.1
XP_054200912.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317333.2 → NP_001304262.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630, AK223550, AL110187
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q53ET9, Q6IBL8
    Related
    ENSP00000403222.1, ENST00000449376.5
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain

  2. NM_001317334.2 → NP_001304263.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 7, encodes isoform b.
    Source sequence(s)
    AC137630, AL110187, BC000422, BG476221, BM928477
    UniProtKB/TrEMBL
    Q59HA2
    Conserved Domains (3) summary
    smart00647
    Location:66 → 128
    IBR; In Between Ring fingers
    cd16773
    Location:1 → 48
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:156 → 188
    IBR; IBR domain, a half RING-finger domain

  3. NM_001349209.2 → NP_001336138.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1, 2, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q53ET9, Q6IBL8
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain

  4. NM_001349210.2 → NP_001336139.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, 4, and 6, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q53ET9, Q6IBL8
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain

  5. NM_001349211.2 → NP_001336140.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 4, and 5, encodes isoform a.
    Source sequence(s)
    AC134028, AC137630
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q53ET9, Q6IBL8
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain

  6. NM_001349212.2 → NP_001336141.1  E3 ubiquitin-protein ligase ARIH2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q59HA2
    Conserved Domains (3) summary
    smart00647
    Location:66 → 128
    IBR; In Between Ring fingers
    cd16773
    Location:1 → 48
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:156 → 188
    IBR; IBR domain, a half RING-finger domain

  7. NM_001349213.2 → NP_001336142.1  E3 ubiquitin-protein ligase ARIH2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes the longest isoform (c).
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  8. NM_001349214.2 → NP_001336143.1  E3 ubiquitin-protein ligase ARIH2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes the longest isoform (c).
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  9. NM_001349215.2 → NP_001336144.1  E3 ubiquitin-protein ligase ARIH2 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) encodes isoform d.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  10. NM_001349216.2 → NP_001336145.1  E3 ubiquitin-protein ligase ARIH2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) encodes isoform e.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  11. NM_001349217.2 → NP_001336146.1  E3 ubiquitin-protein ligase ARIH2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13, 14, 15, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  12. NM_001349218.2 → NP_001336147.1  E3 ubiquitin-protein ligase ARIH2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, 15, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  13. NM_001349219.2 → NP_001336148.1  E3 ubiquitin-protein ligase ARIH2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, 15, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  14. NM_001349220.2 → NP_001336149.1  E3 ubiquitin-protein ligase ARIH2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12, 13, 14, and 16, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  15. NM_001349221.2 → NP_001336150.1  E3 ubiquitin-protein ligase ARIH2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 12, 13, 14, and 15, encodes isoform f.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:226 → 258
    IBR; IBR domain, a half RING-finger domain

  16. NM_001349222.2 → NP_001336151.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 18, 19, 20, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:124 → 186
    IBR; In Between Ring fingers
    cd16773
    Location:53 → 106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:214 → 246
    IBR; IBR domain, a half RING-finger domain

  17. NM_001349223.2 → NP_001336152.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 17, 19, 20, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:124 → 186
    IBR; In Between Ring fingers
    cd16773
    Location:53 → 106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:214 → 246
    IBR; IBR domain, a half RING-finger domain

  18. NM_001349224.2 → NP_001336153.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 17, 18, 20, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:124 → 186
    IBR; In Between Ring fingers
    cd16773
    Location:53 → 106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:214 → 246
    IBR; IBR domain, a half RING-finger domain

  19. NM_001349225.2 → NP_001336154.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 17, 18, 19, and 21, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:124 → 186
    IBR; In Between Ring fingers
    cd16773
    Location:53 → 106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:214 → 246
    IBR; IBR domain, a half RING-finger domain

  20. NM_001349226.2 → NP_001336155.1  E3 ubiquitin-protein ligase ARIH2 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variants 17, 18, 19, and 20, encodes isoform g.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (3) summary
    smart00647
    Location:124 → 186
    IBR; In Between Ring fingers
    cd16773
    Location:53 → 106
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:214 → 246
    IBR; IBR domain, a half RING-finger domain

  21. NM_001349227.2 → NP_001336156.1  E3 ubiquitin-protein ligase ARIH2 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) encodes isoform h.
    Source sequence(s)
    AC134028, AC137630
    UniProtKB/TrEMBL
    Q59HA2
    Conserved Domains (1) summary
    smart00647
    Location:25 → 87
    IBR; In Between Ring fingers

  22. NM_001349228.2 → NP_001336157.1  E3 ubiquitin-protein ligase ARIH2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23), as well as variants 24 and 25, encodes isoform i.
    Source sequence(s)
    AC134028
    UniProtKB/TrEMBL
    C9JCL4

  23. NM_001349229.2 → NP_001336158.1  E3 ubiquitin-protein ligase ARIH2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variants 23 and 25, encodes isoform i.
    Source sequence(s)
    AC134028
    UniProtKB/TrEMBL
    C9JCL4

  24. NM_001349230.2 → NP_001336159.1  E3 ubiquitin-protein ligase ARIH2 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 23 and 24, encodes isoform i.
    Source sequence(s)
    AC134028
    UniProtKB/TrEMBL
    C9JCL4
    Related
    ENSP00000404838.1, ENST00000449729.5

  25. NM_006321.4 → NP_006312.1  E3 ubiquitin-protein ligase ARIH2 isoform a

    See identical proteins and their annotated locations for NP_006312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, 4, 5, and 6, encodes isoform a.
    Source sequence(s)
    AC137630, AL110187, BC000422, BG476221
    Consensus CDS
    CCDS2780.1
    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q53ET9, Q6IBL8
    Related
    ENSP00000348769.4, ENST00000356401.9
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain

RNA

  1. NR_146082.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630

  2. NR_146083.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630

  3. NR_146084.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630

  4. NR_146085.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC134028, AC137630

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    48918842..48986382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453309.2 → XP_024309077.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q53ET9, Q6IBL8
    Conserved Domains (3) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
    pfam01485
    Location:298 → 330
    IBR; IBR domain, a half RING-finger domain

  2. XM_047447278.1 → XP_047303234.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

  3. XM_011533271.2 → XP_011531573.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    See identical proteins and their annotated locations for XP_011531573.1

    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  4. XM_011533268.2 → XP_011531570.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    See identical proteins and their annotated locations for XP_011531570.1

    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:208 → 270
    IBR; In Between Ring fingers
    cd16773
    Location:137 → 190
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  5. XM_047447283.1 → XP_047303239.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

  6. XM_017005534.2 → XP_016861023.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  7. XM_047447284.1 → XP_047303240.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

  8. XM_024453311.2 → XP_024309079.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

    UniProtKB/TrEMBL
    Q59HA2
    Conserved Domains (2) summary
    smart00647
    Location:66 → 128
    IBR; In Between Ring fingers
    cd16773
    Location:1 → 48
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

  9. XM_047447267.1 → XP_047303223.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

  10. XM_047447265.1 → XP_047303221.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

  11. XM_017005535.2 → XP_016861024.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    UniProtKB/TrEMBL
    Q53ET9
    Conserved Domains (2) summary
    smart00647
    Location:136 → 198
    IBR; In Between Ring fingers
    cd16773
    Location:65 → 118
    RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    48947848..49014431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344930.1 → XP_054200905.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

    UniProtKB/Swiss-Prot
    O95376, Q9HBZ6, Q9UEM9
    UniProtKB/TrEMBL
    A0A024R2S5, Q6IBL8

  2. XM_054344934.1 → XP_054200909.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

  3. XM_054344933.1 → XP_054200908.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

  4. XM_054344928.1 → XP_054200903.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

  5. XM_054344935.1 → XP_054200910.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

  6. XM_054344931.1 → XP_054200906.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

  7. XM_054344936.1 → XP_054200911.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

  8. XM_054344937.1 → XP_054200912.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

  9. XM_054344927.1 → XP_054200902.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

  10. XM_054344929.1 → XP_054200904.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

  11. XM_054344932.1 → XP_054200907.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95376.1 GenPept UniProtKB/Swiss-Prot:O95376

Gene LinkOut

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