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Cdh22 cadherin 22 [ Mus musculus (house mouse) ]

Gene ID: 104010, updated on 11-Apr-2024

Summary

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Official Symbol
Cdh22provided by MGI
Official Full Name
cadherin 22provided by MGI
Primary source
MGI:MGI:1341843
See related
Ensembl:ENSMUSG00000053166 AllianceGenome:MGI:1341843
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in several structures, including central nervous system; heart; limb; limb bud; and retina. Orthologous to human CDH22 (cadherin 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 8.6), frontal lobe adult (RPKM 5.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Cdh22 in Genome Data Viewer
Location:
2 H3; 2 85.43 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164953421..165076892, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165111501..165234924, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700025C18 gene Neighboring gene STARR-seq mESC enhancer starr_06347 Neighboring gene predicted gene, 36690 Neighboring gene predicted gene, 36803 Neighboring gene predicted gene, 36748 Neighboring gene predicted gene, 25569 Neighboring gene solute carrier family 35, member C2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transposition-based method for the rapid generation of gene-targeting vectors to produce Cre/Flp-modifiable conditional knock-out mice. Turakainen H, et al. PLoS One, 2009. PMID 19194496, Free PMC Article
  2. AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells. Zhang X, et al. Stem Cells, 2019 Aug. PMID 31041846
  3. Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin. Zhang X, et al. Cell Mol Life Sci, 2018 Apr. PMID 29063123
  4. Molecular cloning and characterization of a newly identified member of the cadherin family, PB-cadherin. Sugimoto K, et al. J Biol Chem, 1996 May 10. PMID 8626716
  5. Expression of a novel type of classic cadherin, PB-cadherin in developing brain and limb buds. Kitajima K, et al. Dev Dyn, 1999 Jul. PMID 10398531

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. glial cell line-derived neurotrophic factor (GDNF) was identified as an essential factor for FGSCs self-renewal with a more complicated mechanism: GDNF-GFRA1 activates AKT3 via PI3K or Src family kinase (SFK), and SFK upregulates its target genes, Bcl6b, Etv5, and Lhx1, to promote self-renewal of Female germline stem cells.
    Title: AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells.
  2. Janus kinase 2 protein (JAK2) and beta-catenin were found to interact with cadherin-22 (Cdh22) and involved in CDH22 signaling in female germ line stem cells (FGSCs).
    Title: Cadherin 22 participates in the self-renewal of mouse female germ line stem cells via interaction with JAK2 and β-catenin.
  3. Results describe the expression of Cdh22 in developing mouse brain and compare it to expression of related family members.
    Title: Analysis of Cdh22 expression and function in the developing mouse brain.
  4. spatio-temporal mRNA distribution pattern of Cdh12 and Cdh22 during CNS development; demonstrate presence of Cdh12 and Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS including cerebellum, neocortex, hippocampus and subcortical nuclei
    Title: Expression of two type II cadherins, Cdh12 and Cdh22 in the developing and adult mouse brain.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cadherin-22
Names
PB-cadherin
pituitary and brain cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174988.3 → NP_778153.2  cadherin-22 precursor

    See identical proteins and their annotated locations for NP_778153.2

    Status: VALIDATED

    Source sequence(s)
    AK140248, AL591411, BC112407
    Consensus CDS
    CCDS17073.1
    UniProtKB/Swiss-Prot
    I7HIP9, Q9WTP5
    Related
    ENSMUSP00000066864.7, ENSMUST00000065438.13
    Conserved Domains (2) summary
    cd11304
    Location:398 → 492
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:645 → 804
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    164953421..165076892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157158.1 → XP_036013051.1  cadherin-22 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:276 → 370
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:523 → 682
    Cadherin_C; Cadherin cytoplasmic region

  2. XM_006498536.5 → XP_006498599.1  cadherin-22 isoform X4

    Conserved Domains (3) summary
    cd11304
    Location:95 → 193
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:22 → 90
    CA; Cadherin repeats
    pfam01049
    Location:241 → 400
    Cadherin_C; Cadherin cytoplasmic region

  3. XM_036157156.1 → XP_036013049.1  cadherin-22 isoform X1

    UniProtKB/Swiss-Prot
    I7HIP9, Q9WTP5
    Conserved Domains (2) summary
    cd11304
    Location:398 → 492
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:645 → 804
    Cadherin_C; Cadherin cytoplasmic region

  4. XM_006498534.4 → XP_006498597.1  cadherin-22 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:276 → 370
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:523 → 682
    Cadherin_C; Cadherin cytoplasmic region

  5. XM_030246473.2 → XP_030102333.1  cadherin-22 isoform X3

    Conserved Domains (1) summary
    cd11304
    Location:398 → 492
    Cadherin_repeat; Cadherin tandem repeat domain

RNA

  1. XR_003949827.2 RNA Sequence

  2. XR_004937403.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTP5.2 GenPept UniProtKB/Swiss-Prot:Q9WTP5

Gene LinkOut

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