Qsox1 quiescin Q6 sulfhydryl oxidase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Qsox1provided by MGI
Official Full Name: quiescin Q6 sulfhydryl oxidase 1provided by MGI
Primary source: MGI:MGI:1330818
See related: Ensembl:ENSMUSG00000033684 AllianceGenome:MGI:1330818
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SOx; QSOX; Qscn6; b2b2673Clo; 1300003H02Rik
Summary: Predicted to enable FAD binding activity; flavin-linked sulfhydryl oxidase activity; and protein disulfide isomerase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and skin. Used to study VACTERL association. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 148.9), liver E18 (RPKM 139.0) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 67.64 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (155653901..155688645, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (155778155..155812899, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases.
Title: The disulfide catalyst QSOX1 maintains the colon mucosal barrier by regulating Golgi glycosyltransferases.
Functional significance of mouse seminal vesicle sulfhydryl oxidase on sperm capacitation in vitro.
Title: Functional significance of mouse seminal vesicle sulfhydryl oxidase on sperm capacitation in vitro.
Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.
Title: Polarized epithelium-sperm co-culture system reveals stimulatory factors for the secretion of mouse epididymal quiescin sulfhydryl oxidase 1.
Quiescin/sulfhydryl oxidase 1b (QSOX1b) induces migration and proliferation of vascular smooth muscle cells by distinct redox pathways
Title: Quiescin/sulfhydryl oxidase 1b (QSOX1b) induces migration and proliferation of vascular smooth muscle cells by distinct redox pathways.
our study provides the first comprehensive comparisons between QSOX1 and QSOX2 in the mouse epididymis, revealing their distinct epididymal distribution, cellular localization, mechanisms of secretion and sperm membrane association
Title: Mouse quiescin sulfhydryl oxidases exhibit distinct epididymal luminal distribution with segment-specific sperm surface associations.
the data indicated that QSOX1 is required 1) for a proper protein folding in the endo/sarcoplasmic reticulum (ER/SR) and 2) for resolution and protective response during acute stress.
Title: QSOX1, a novel actor of cardiac protection upon acute stress in mice.
Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms, in particular, by the serum QSOX1.
Title: Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
QSOX1 inhibits autophagy in breast cancer cells.
Title: QSOX1 inhibits autophagic flux in breast cancer cells.
crystal structure
Title: The dynamic disulphide relay of quiescin sulphydryl oxidase.
cloned skin SOx cDNA and characterized it as one of the disulfide (S-S) cross-linking enzymes
Title: Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Chemically induced (ENU) (1)
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables flavin-dependent sulfhydryl oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin-dependent sulfhydryl oxidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein disulfide isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein disulfide isomerase activity	ISO Inferred from Sequence Orthology more info
enables thiol oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sulfhydryl oxidase 1

Names: skin sulfhydryl oxidase

NP_001020116.1

EC 1.8.3.2

NP_075757.1

EC 1.8.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024945.1 → NP_001020116.1 sulfhydryl oxidase 1 isoform a precursor

See identical proteins and their annotated locations for NP_001020116.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

AK083938, BY334148, CK625426

Consensus CDS

CCDS15386.1

UniProtKB/Swiss-Prot

Q3TDY9, Q3TE19, Q3TR29, Q3UEL4, Q8BND5, Q8K041, Q9DBL6

Related

ENSMUSP00000035658.9, ENSMUST00000035325.15

Conserved Domains (2) summary

cd02992
Location:43 → 155

PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...

pfam04777
Location:409 → 501

Evr1_Alr; Erv1 / Alr family
NM_023268.2 → NP_075757.1 sulfhydryl oxidase 1 isoform b precursor

See identical proteins and their annotated locations for NP_075757.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AB044284, AK083938, BY334148, CK625426

Consensus CDS

CCDS78713.1

UniProtKB/Swiss-Prot

Q8BND5

Related

ENSMUSP00000142301.2, ENSMUST00000194632.2

Conserved Domains (2) summary

cd02992
Location:43 → 155

PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...

pfam04777
Location:409 → 501

Evr1_Alr; Erv1 / Alr family