Dnm3 dynamin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnm3provided by MGI
Official Full Name: dynamin 3provided by MGI
Primary source: MGI:MGI:1341299
See related: Ensembl:ENSMUSG00000040265 AllianceGenome:MGI:1341299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dyna III; mKIAA0820; C530045C17; 9630020E24Rik; B230343F03Rik
Summary: Predicted to enable several functions, including G protein-coupled glutamate receptor binding activity; GTPase activity; and nitric-oxide synthase binding activity. Predicted to be a structural constituent of postsynapse. Involved in synaptic vesicle budding from presynaptic endocytic zone membrane. Located in photoreceptor inner segment and presynapse. Is expressed in several structures, including 1st branchial arch; central nervous system; genitourinary system; musculature; and paraxial mesenchyme. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 19.2), CNS E18 (RPKM 12.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H2.1; 1 69.95 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (161810022..162305890, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (161982450..162478321, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in the mature epididymis, predominantly localized in principal cells of the distal segments
Title: Developmental expression of the dynamin family of mechanoenzymes in the mouse epididymis.
The data of this study demonstrated that dynamin 3 is required for the formation, functional maturation, and subsequent survival of the calyx of Held.
Title: Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo.
In the developing neurons, there is a dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.
Title: A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.
As low-level expression of the dynamin 3 gene in these cells could not be excluded, we have now engineered dynamin 1, 2 and 3 triple KO (TKO) fibroblasts.
Title: Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors.
Data indicate that coxsackievirus and adenovirus receptor (CAR) internalization was lipid microdomain-, actin-, and dynamin-dependent, and subsequently followed by CAR degradation in lysosomes.
Title: Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting.
Data indicate that dynamin, clathrin, adaptor protein complex-2 (AP2), and amphiphysin contribute to the depolarization-evoked entry in endocytosis.
Title: Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.
These findings reveal a mechanism aimed at preventing synaptic transmission failure due to vesicle depletion when recycling vesicle traffic is backed up by a defect in dynamin-dependent endocytosis.
Title: Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.
Lack of dynamin 3 does not produce an overt phenotype in mice; however, it worsens the dynamin 1 KO phenotype, leading to perinatal lethality and a more severe defect in activity-dependent synaptic vesicle endocytosis.
Title: Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.
Dynamin 3 participates in the growth and development of megakaryocytes.
Title: Dynamin 3 participates in the growth and development of megakaryocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dnm3 (e-PCR), detects polymorphism
- UniSTS:472837

Dnm3os (e-PCR), detects polymorphism
- UniSTS:472838

AW061159 (e-PCR)
- UniSTS:178487

D1Mit504 (e-PCR), detects polymorphism
- UniSTS:128874

D1Mit505 (e-PCR), detects polymorphism
- UniSTS:128875

Z31360 (e-PCR)
- UniSTS:158873

D1Pgn5 (e-PCR), detects polymorphism
- UniSTS:265654

D1Mit106 (e-PCR), detects polymorphism
- UniSTS:128442

D1Mit107 (e-PCR), detects polymorphism
- UniSTS:128443

NoName (e-PCR)
- UniSTS:224462

D1Mit398 (e-PCR), detects polymorphism
- UniSTS:128759

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynapse	ISO Inferred from Sequence Orthology more info
enables type 1 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables type 5 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle recycling	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of apical tubulobulbar complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
part_of basal tubulobulbar complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic endocytic zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic cleft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynamin-3

Names: dynamin III; t-dynamin; testicular dynamin

NP_001033708.1

EC 3.6.5.5

NP_766234.1

EC 3.6.5.5

XP_006496664.1

EC 3.6.5.5

XP_006496665.1

EC 3.6.5.5

XP_006496666.1

EC 3.6.5.5

XP_006496667.1

EC 3.6.5.5

XP_006496668.1

EC 3.6.5.5

XP_030110486.1

EC 3.6.5.5

XP_036021487.1

EC 3.6.5.5

XP_036021507.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038619.2 → NP_001033708.1 dynamin-3 isoform 1

See identical proteins and their annotated locations for NP_001033708.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK046124, AK049724, AK147678, AW047427

UniProtKB/Swiss-Prot

B2RUH0, Q3UGY9, Q80TR2, Q8BWW6, Q8BZ98

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (6) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

COG0699
Location:79 → 738

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:217 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:651 → 739

GED; Dynamin GTPase effector domain

pfam15087
Location:748 → 831

DUF4551; Protein of unknown function (DUF4551)
NM_172646.3 → NP_766234.1 dynamin-3 isoform 2

See identical proteins and their annotated locations for NP_766234.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2).

Source sequence(s)

AK046124, AK049724, AK147678, AW047427

Consensus CDS

CCDS48417.1

UniProtKB/TrEMBL

E9QLL2

Related

ENSMUSP00000064538.8, ENSMUST00000070330.14

Conserved Domains (6) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

COG0699
Location:79 → 734

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:217 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain

pfam15087
Location:744 → 827

DUF4551; Protein of unknown function (DUF4551)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

161810022..162305890 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165594.1 → XP_036021487.1 dynamin-3 isoform X6

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:657 → 745

GED; Dynamin GTPase effector domain

pfam06346
Location:753 → 838

Drf_FH1; Formin Homology Region 1
XM_006496604.5 → XP_006496667.1 dynamin-3 isoform X4

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03307
Location:752 → 842

PHA03307; transcriptional regulator ICP4; Provisional

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:660 → 749

GED; Dynamin GTPase effector domain
XM_036165614.1 → XP_036021507.1 dynamin-3 isoform X7

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

PHA03247
Location:738 → 841

PHA03247; large tegument protein UL36; Provisional

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_006496602.4 → XP_006496665.1 dynamin-3 isoform X2

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam15822
Location:753 → 841

MISS; MAPK-interacting and spindle-stabilizing protein-like

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:656 → 745

GED; Dynamin GTPase effector domain
XM_030254626.2 → XP_030110486.1 dynamin-3 isoform X5

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam15822
Location:753 → 843

MISS; MAPK-interacting and spindle-stabilizing protein-like

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:656 → 745

GED; Dynamin GTPase effector domain
XM_006496601.4 → XP_006496664.1 dynamin-3 isoform X1

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam15822
Location:757 → 845

MISS; MAPK-interacting and spindle-stabilizing protein-like

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:660 → 749

GED; Dynamin GTPase effector domain
XM_006496603.5 → XP_006496666.1 dynamin-3 isoform X3

UniProtKB/TrEMBL

E9QLL2

Conserved Domains (5) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam15822
Location:757 → 847

MISS; MAPK-interacting and spindle-stabilizing protein-like

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:660 → 749

GED; Dynamin GTPase effector domain
XM_006496605.4 → XP_006496668.1 dynamin-3 isoform X8

Conserved Domains (2) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region