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Hoxb2 homeobox B2 [ Mus musculus (house mouse) ]

Gene ID: 103889, updated on 5-Mar-2024

Summary

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Official Symbol
Hoxb2provided by MGI
Official Full Name
homeobox B2provided by MGI
Primary source
MGI:MGI:96183
See related
Ensembl:ENSMUSG00000075588 AllianceGenome:MGI:96183
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hox-2.8; Hoxbes2
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including central nervous system development; embryonic skeletal system morphogenesis; and regionalization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including branchial arch; future hindbrain; lung; metanephros; and nervous system. Orthologous to human HOXB2 (homeobox B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 30.9), genital fat pad adult (RPKM 12.5) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Hoxb2 in Genome Data Viewer
Location:
11 D; 11 59.85 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96242458..96244846)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96351632..96354020)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene homeobox B3 Neighboring gene homeobox B4 Neighboring gene predicted gene 11536 Neighboring gene homeobox B3 and homeobox B2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_30549 Neighboring gene origin of replication 3' to Hoxb1 Neighboring gene homeobox B1 Neighboring gene STARR-seq mESC enhancer starr_30551 Neighboring gene ribosomal protein L17 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem. Karmakar K, et al. Cell Rep, 2017 Jan 3. PMID 28052248
  2. A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer. Boimel PJ, et al. Genomics, 2011 Sep. PMID 21672623, Free PMC Article
  3. HOXBES2: a novel epididymal HOXB2 homeoprotein and its domain-specific association with spermatozoa. Prabagaran E, et al. Biol Reprod, 2007 Feb. PMID 17065603
  4. Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse. Roelen BA, et al. Mech Dev, 2002 Nov. PMID 12385756
  5. [Molecular analysis of the development of the rhombencephalon]. Vesque C, et al. C R Seances Soc Biol Fil, 1993. PMID 8019912

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results establish a role for Hox factors in tonotopic refinement of connectivity and in ensuring the precision of sound transmission in the mammalian auditory circuit.
    Title: Hox2 Genes Are Required for Tonotopic Map Precision and Sound Discrimination in the Mouse Auditory Brainstem.
  2. Hoxb2 antagonizes Hoxa2 during rostral hindbrain oligodendrogenesis.
    Title: Opposing roles for Hoxa2 and Hoxb2 in hindbrain oligodendrocyte patterning.
  3. HOXB2 acts as a negative tumor growth regulator, decreasing proliferation in mammary adenocarcinoma tumors.
    Title: A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer.
  4. Interaction of HoxB2 with mutant SOD1 occurs in motor neurons of G93A mutant SOD1 transgenic mice and suggest that this interaction may modulate the neurotoxicity of mutant SOD1.
    Title: HoxB2 binds mutant SOD1 and is altered in transgenic model of ALS.
  5. results describe the functional requirements in hindbrain neuronal patterning that follow the establishment of the genetic regulatory hierarchy between Hoxa1, Hoxb1 and Hoxb2
    Title: Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryonic skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial sheet IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural nucleus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhombomere 3 development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within rhombomere 4 development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
homeobox protein Hox-B2
Names
homeo box B2
homeobox protein Hox-2.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134032.2 → NP_598793.2  homeobox protein Hox-B2

    See identical proteins and their annotated locations for NP_598793.2

    Status: VALIDATED

    Source sequence(s)
    AI893165, AL606824
    Consensus CDS
    CCDS36290.1
    UniProtKB/Swiss-Prot
    A2A739, B9EHW9, P0C1T1
    Related
    ENSMUSP00000098092.5, ENSMUST00000100523.7
    Conserved Domains (1) summary
    pfam00046
    Location:145 → 197
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96242458..96244846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531932.5 → XP_006531995.1  homeobox protein Hox-B2 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:23 → 76
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C1T1.1 GenPept UniProtKB/Swiss-Prot:P0C1T1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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