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Cuedc1 CUE domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 103841, updated on 5-Mar-2024

Summary

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Official Symbol
Cuedc1provided by MGI
Official Full Name
CUE domain containing 1provided by MGI
Primary source
MGI:MGI:2144281
See related
Ensembl:ENSMUSG00000018378 AllianceGenome:MGI:2144281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330016O16Rik
Summary
Predicted to enable ubiquitin binding activity. Is expressed in intestine smooth muscle circular layer. Orthologous to human CUEDC1 (CUE domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 24.2), bladder adult (RPKM 20.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 C; 11 52.4 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87989972..88084966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88099146..88194140)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene serine and arginine-rich splicing factor 1 Neighboring gene vascular endothelial zinc finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene STARR-seq mESC enhancer starr_30316 Neighboring gene STARR-positive B cell enhancer ABC_E8441 Neighboring gene mitochondrial ribosomal protein S23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88047672-88047825 Neighboring gene STARR-positive B cell enhancer ABC_E7041 Neighboring gene predicted gene, 38534 Neighboring gene VISTA enhancer mm439 Neighboring gene predicted gene, 34366

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. McLelland GL, et al. Elife, 2018 Apr 20. PMID 29676259, Free PMC Article
  2. Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Gurdziel K, et al. Dev Dyn, 2016 May. PMID 26930384, Free PMC Article
  3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
CUE domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172099.1 → NP_001165570.1  CUE domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The 5' UTR for this variant has not been determined. The resulting isoform (2) includes a three amino acid segment near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL593853
    UniProtKB/TrEMBL
    B7ZNF1
    Conserved Domains (1) summary
    cd14366
    Location:50 → 91
    CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

  2. NM_198013.3 → NP_932130.2  CUE domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_932130.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK049250, BC131989, CF950088, CJ113091, CJ118464, CK332869, EL962896
    Consensus CDS
    CCDS25226.1
    UniProtKB/Swiss-Prot
    Q5SXC2, Q8R3V6
    UniProtKB/TrEMBL
    A2RS63
    Related
    ENSMUSP00000018522.7, ENSMUST00000018522.13
    Conserved Domains (1) summary
    cd14366
    Location:50 → 91
    CUE_CUED1; CUE domain found in CUE domain-containing protein 1 (CUED1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87989972..88084966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3V6.2 GenPept UniProtKB/Swiss-Prot:Q8R3V6

Gene LinkOut

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