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Slc25a41 solute carrier family 25, member 41 [ Mus musculus (house mouse) ]

Gene ID: 103775, updated on 5-Mar-2024

Summary

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Official Symbol
Slc25a41provided by MGI
Official Full Name
solute carrier family 25, member 41provided by MGI
Primary source
MGI:MGI:2144215
See related
Ensembl:ENSMUSG00000011486 AllianceGenome:MGI:2144215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SCaMC-3L; 4933406J04Rik
Summary
Enables ADP transmembrane transporter activity and ATP transmembrane transporter activity. Involved in mitochondrial ADP transmembrane transport and mitochondrial ATP transmembrane transport. Located in mitochondrion. Orthologous to human SLC25A41 (solute carrier family 25 member 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 9.3), ovary adult (RPKM 3.9) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 D; 17 29.63 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57339772..57348654, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57032772..57041654, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene adenylate kinase 5 pseudogene Neighboring gene KH-type splicing regulatory protein Neighboring gene STARR-positive B cell enhancer ABC_E142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:57171392-57171575 Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 Neighboring gene STARR-positive B cell enhancer ABC_E3211 Neighboring gene crumbs family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of SCaMC-3-like/slc25a41, a novel calcium-independent mitochondrial ATP-Mg/Pi carrier. Traba J, et al. Biochem J, 2009 Feb 15. PMID 18928449
  2. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
  3. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Haitina T, et al. Genomics, 2006 Dec. PMID 16949250
  4. Resistance to noise-induced hearing loss in 129S6 and MOLF mice: identification of independent, overlapping, and interacting chromosomal regions. Street VA, et al. J Assoc Res Otolaryngol, 2014 Oct. PMID 24952082, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mouse SCaMC-3L shows a limited expression pattern; it is preferentially expressed in testis and, at lower levels, in brain
    Title: Characterization of SCaMC-3-like/slc25a41, a novel calcium-independent mitochondrial ATP-Mg/Pi carrier.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ATP transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ADP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ADP transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ATP transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ATP transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ADP transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ATP transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-independent mitochondrial carrier protein SCaMC-3L
Names
SCaMC-3-like
mitochondrial ATP-Mg/Pi carrier protein
mitochondrial ATP-Mg/Pi carrier protein SLC25A41
small calcium-binding mitochondrial carrier protein 3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346527.1 → NP_001333456.1  calcium-independent mitochondrial carrier protein SCaMC-3L isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT571247
    Consensus CDS
    CCDS84326.1
    UniProtKB/Swiss-Prot
    Q8BVN7
    Related
    ENSMUSP00000130857.2, ENSMUST00000169012.2

  2. NM_175333.3 → NP_780542.1  calcium-independent mitochondrial carrier protein SCaMC-3L isoform 1

    See identical proteins and their annotated locations for NP_780542.1

    Status: VALIDATED

    Source sequence(s)
    AK077111, BX637138
    Consensus CDS
    CCDS37668.1
    UniProtKB/Swiss-Prot
    B8ZHC8, Q14BV4, Q8BVN7
    Related
    ENSMUSP00000058877.8, ENSMUST00000058661.14
    Conserved Domains (2) summary
    PTZ00169
    Location:23 → 305
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:25 → 116
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    57339772..57348654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVN7.1 GenPept UniProtKB/Swiss-Prot:Q8BVN7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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