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Mien1 migration and invasion enhancer 1 [ Mus musculus (house mouse) ]

Gene ID: 103742, updated on 7-Apr-2024

Summary

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Official Symbol
Mien1provided by MGI
Official Full Name
migration and invasion enhancer 1provided by MGI
Primary source
MGI:MGI:1913678
See related
Ensembl:ENSMUSG00000002580 AllianceGenome:MGI:1913678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdx12; 1810046J19Rik
Summary
Predicted to be involved in several processes, including positive regulation of cell migration; positive regulation of filopodium assembly; and response to selenium ion. Predicted to act upstream of or within apoptotic process. Located in cytosol. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human MIEN1 (migration and invasion enhancer 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 66.7), duodenum adult (RPKM 55.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 61.75 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98328534..98349056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98437708..98458230, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98254740-98254849 Neighboring gene STARR-seq mESC enhancer starr_30667 Neighboring gene post-GPI attachment to proteins 3 Neighboring gene phenylethanolamine-N-methyltransferase Neighboring gene erb-b2 receptor tyrosine kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E5275 Neighboring gene STARR-seq mESC enhancer starr_30668 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320467-98320833 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98320999-98321108 Neighboring gene growth factor receptor bound protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E11772 Neighboring gene IKAROS family zinc finger 3 Neighboring gene predicted gene, 25106 Neighboring gene STARR-positive B cell enhancer ABC_E7058 Neighboring gene VISTA enhancer mm503 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98388491-98388674 Neighboring gene STARR-positive B cell enhancer ABC_E8880 Neighboring gene STARR-positive B cell enhancer ABC_E8450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98412942-98413125 Neighboring gene zona pellucida binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Dikiy A, et al. Biochemistry, 2007 Jun 12. PMID 17503775
  2. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
    Title: Short peptides based on the conserved regions of MIEN1 protein exhibit anticancer activity by targeting the MIEN1 signaling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
migration and invasion enhancer 1
Names
protein C17orf37 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025559.2 → NP_079835.1  migration and invasion enhancer 1

    See identical proteins and their annotated locations for NP_079835.1

    Status: VALIDATED

    Source sequence(s)
    AK007795, BE623929, CA530220
    Consensus CDS
    CCDS25350.1
    UniProtKB/Swiss-Prot
    A2A556, Q9CQ86
    Related
    ENSMUSP00000002655.8, ENSMUST00000002655.8
    Conserved Domains (1) summary
    TIGR02174
    Location:25 → 95
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98328534..98349056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245455.1 → XP_030101315.1  migration and invasion enhancer 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A556, Q9CQ86
    Conserved Domains (1) summary
    TIGR02174
    Location:25 → 95
    CXXU_selWTH; selT/selW/selH selenoprotein domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ86.1 GenPept UniProtKB/Swiss-Prot:Q9CQ86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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