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Tubg1 tubulin, gamma 1 [ Mus musculus (house mouse) ]

Gene ID: 103733, updated on 30-Apr-2024

Summary

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Official Symbol
Tubg1provided by MGI
Official Full Name
tubulin, gamma 1provided by MGI
Primary source
MGI:MGI:101834
See related
Ensembl:ENSMUSG00000035198 AllianceGenome:MGI:101834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tubg; GCP-1; 1500010O08Rik
Summary
Predicted to enable GTP binding activity and identical protein binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within meiotic spindle organization. Located in several cellular components, including condensed nuclear chromosome; microtubule cytoskeleton; and non-motile cilium. Is expressed in several structures, including eye; heart; nervous system; notochord; and respiratory system. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to human TUBG1 (tubulin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.9), adrenal adult (RPKM 13.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 64.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101010725..101017249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101119904..101126423)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11773 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein Neighboring gene MAX-like protein X Neighboring gene reticulophagy regulator family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E4001 Neighboring gene STARR-positive B cell enhancer ABC_E1843 Neighboring gene tubulin, gamma 2 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. gamma-Tubulin is present in acentriolar MTOCs during early mouse development. Gueth-Hallonet C, et al. J Cell Sci, 1993 May. PMID 8360270
  2. Fodrin in centrosomes: implication of a role of fodrin in the transport of gamma-tubulin complex in brain. Shashikala S, et al. PLoS One, 2013. PMID 24098540, Free PMC Article
  3. Knockdown of UCHL5IP causes abnormalities in γ-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation. Wang YP, et al. Reprod Fertil Dev, 2013. PMID 23182369
  4. MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages. Eng EW, et al. Mol Biol Cell, 2007 Jul. PMID 17442887, Free PMC Article
  5. Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte. Barrett SL, et al. Biol Reprod, 2007 Jun. PMID 17287496

See all (217) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study investigated the consequences of four human malformations of cortical development-related TUBG1 variants by using in utero electroporation and a knock-in Tubg1Y92C/+ mouse model and show that pathogenic TUBG1 variants affect neuronal positioning by disrupting neuronal migration and affecting microtubule dynamics rather than centrosomal positioning or nucleation ability.
    Title: TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.
  2. Fodrin is a regulatory transporter of gamma-tubulin to the centrosomes for normal progression of mitosis.
    Title: Fodrin in centrosomes: implication of a role of fodrin in the transport of gamma-tubulin complex in brain.
  3. Data suggest that localization of Tubg1 (and Plk1 [polo-like kinase 1]) to spindle poles during oocyte meiotic maturation/oogenesis (metaphase I/II) requires participation of Uchl5ip/Haus7 (HAUS augmin-like complex subunit 7).
    Title: Knockdown of UCHL5IP causes abnormalities in γ-tubulin localisation, spindle organisation and chromosome alignment in mouse oocyte meiotic maturation.
  4. a direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome
    Title: A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome.
  5. SADB kinase activity controls centrosome homeostasis by regulating phosphorylation of gamma-tubulin.
    Title: SADB phosphorylation of gamma-tubulin regulates centrosome duplication.
  6. Results suggest that Fyn and PI3K might take part in the modulation of membrane-associated gamma-tubulin activities.
    Title: Regulation of microtubule nucleation from membranes by complexes of membrane-bound gamma-tubulin with Fyn kinase and phosphoinositide 3-kinase.
  7. pPKCdelta(Thr505) interacts with MTOC-associated proteins pericentrin and gamma-tubulin, and plays a role in meiotic spindle organization in oocytes
    Title: Protein kinase C delta (PKCdelta) interacts with microtubule organizing center (MTOC)-associated proteins and participates in meiotic spindle organization.
  8. Gamma-tubulin is a key regulator of asymmetric cytokinesis in mouse oocytes.
    Title: Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8041

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic spindle organization IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation TAS
Traceable Author Statement
more info
 PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule organizing center TAS
Traceable Author Statement
more info
 PubMed 
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polar microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
tubulin gamma-1 chain
Names
gamma-tubulin complex component 1
tubulin, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134024.3 → NP_598785.1  tubulin gamma-1 chain

    See identical proteins and their annotated locations for NP_598785.1

    Status: VALIDATED

    Source sequence(s)
    BX255926
    Consensus CDS
    CCDS25451.1
    UniProtKB/Swiss-Prot
    P83887, Q9Z310
    UniProtKB/TrEMBL
    Q6F4J1
    Related
    ENSMUSP00000048036.9, ENSMUST00000043680.9
    Conserved Domains (1) summary
    cd02188
    Location:3 → 435
    gamma_tubulin; The gamma-tubulin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101010725..101017249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314211.3 → XP_017169700.1  tubulin gamma-1 chain isoform X1

    Conserved Domains (1) summary
    cd02188
    Location:65 → 390
    gamma_tubulin; The gamma-tubulin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83887.1 GenPept UniProtKB/Swiss-Prot:P83887

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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