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Sec14l4 SEC14-like lipid binding 4 [ Mus musculus (house mouse) ]

Gene ID: 103655, updated on 8-Feb-2024

Summary

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Official Symbol
Sec14l4provided by MGI
Official Full Name
SEC14-like lipid binding 4provided by MGI
Primary source
MGI:MGI:2144095
See related
Ensembl:ENSMUSG00000019368 AllianceGenome:MGI:2144095
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SPF; TAP
Summary
Predicted to enable lipid binding activity. Orthologous to several human genes including SEC14L4 (SEC14 like lipid binding 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 35.1), lung adult (RPKM 18.2) and 3 other tissues See more
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Genomic context

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Location:
11 A1; 11 2.84 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3981377..3998426)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4031378..4048426)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 1 Neighboring gene predicted gene, 46265 Neighboring gene predicted gene 11954 Neighboring gene STARR-seq mESC enhancer starr_28368 Neighboring gene SEC14-like lipid binding 3 Neighboring gene predicted gene, 51935 Neighboring gene mitochondrial fission process 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice. Herbas MS, et al. Am J Clin Nutr, 2010 Jan. PMID 19923370
  2. Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. Shibata N, et al. FASEB J, 2006 Dec. PMID 17077281
  3. Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. Hirashima S, et al. J Biol Chem, 1988 Mar 15. PMID 3346229
  4. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. Yeh CH, et al. Gene, 1994 Jun 10. PMID 8206389
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency of alpha-tocopherol in the circulation prevents cerebral malaria suggesting that this protein may be involved in early prevention of malaria.
    Title: alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice.
  2. The expression of SPF in response to food deprivation and fibrate administration is reported in wild-type and knockouk mice.
    Title: Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30313

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SEC14-like protein 4
Names
SEC14-like 2
SEC14-like 4
alpha-tocopherol associated protein
squalene transfer protein
supernatant protein factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146013.1 → NP_666125.1  SEC14-like protein 4

    See identical proteins and their annotated locations for NP_666125.1

    Status: PROVISIONAL

    Source sequence(s)
    BC026948
    Consensus CDS
    CCDS24374.1
    UniProtKB/Swiss-Prot
    Q8R0F9
    Related
    ENSMUSP00000019512.8, ENSMUST00000019512.8
    Conserved Domains (3) summary
    smart00516
    Location:77 → 244
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:13 → 59
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam13897
    Location:284 → 379
    GOLD_2; Golgi-dynamics membrane-trafficking

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3981377..3998426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514437.3 → XP_006514500.1  SEC14-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006514500.1

    Conserved Domains (2) summary
    smart00516
    Location:23 → 190
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    pfam13897
    Location:230 → 325
    GOLD_2; Golgi-dynamics membrane-trafficking

  2. XM_006514438.3 → XP_006514501.1  SEC14-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006514501.1

    Conserved Domains (2) summary
    smart00516
    Location:23 → 190
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    pfam13897
    Location:230 → 325
    GOLD_2; Golgi-dynamics membrane-trafficking

  3. XM_006514439.3 → XP_006514502.1  SEC14-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006514502.1

    Conserved Domains (2) summary
    smart00516
    Location:23 → 190
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    pfam13897
    Location:230 → 325
    GOLD_2; Golgi-dynamics membrane-trafficking
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R0F9.1 GenPept UniProtKB/Swiss-Prot:Q8R0F9

Gene LinkOut

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