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Nt5dc3 5'-nucleotidase domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 103466, updated on 5-Mar-2024

Summary

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Official Symbol
Nt5dc3provided by MGI
Official Full Name
5'-nucleotidase domain containing 3provided by MGI
Primary source
MGI:MGI:3513266
See related
Ensembl:ENSMUSG00000054027 Ensembl:ENSMUSG00000112743 AllianceGenome:MGI:3513266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TU12B1-TY; C630002B14Rik
Summary
Predicted to enable 5'-nucleotidase activity. Located in cytosol. Is expressed in several structures, including genitourinary system; gut; liver; lung; and thymus. Orthologous to human NT5DC3 (5'-nucleotidase domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 15.7), adrenal adult (RPKM 14.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Nt5dc3 in Genome Data Viewer
Location:
10 C1; 10 43.11 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (86614857..86674253)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (86778992..86838389)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, beta (Grp94), member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:86190323-86190623 Neighboring gene STARR-positive B cell enhancer ABC_E11451 Neighboring gene tetratricopeptide repeat domain 41 Neighboring gene fatty acid binding protein 3, muscle and heart, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_27469 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86240990-86241290 Neighboring gene STARR-positive B cell enhancer mm9_chr10:86241543-86241844 Neighboring gene STARR-positive B cell enhancer ABC_E8356 Neighboring gene STARR-seq mESC enhancer starr_27475 Neighboring gene stabilin 2 Neighboring gene ADNP homeobox 2 pseudogene Neighboring gene predicted gene 16271 Neighboring gene predicted gene, 53582

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The common viral insertion site Evi12 is located in the 5'-noncoding region of Gnn, a novel gene with enhanced expression in two subclasses of human acute myeloid leukemia. van den Akker E, et al. J Virol, 2005 May. PMID 15827139, Free PMC Article
  2. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Ghai R, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382219, Free PMC Article
  3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
5'-nucleotidase domain-containing protein 3
Names
TU12B1-TY protein homolog
NP_780540.2
XP_036011377.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175331.3 → NP_780540.2  5'-nucleotidase domain-containing protein 3

    See identical proteins and their annotated locations for NP_780540.2

    Status: VALIDATED

    Source sequence(s)
    AK147488, CJ098720, CJ256052
    Consensus CDS
    CCDS36020.1
    UniProtKB/Swiss-Prot
    Q3T9W5, Q3UHB1
    Related
    ENSMUSP00000096994.3, ENSMUST00000099396.3
    Conserved Domains (1) summary
    pfam05761
    Location:91 → 524
    5_nucleotid; 5' nucleotidase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    86614857..86674253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155484.1 → XP_036011377.1  5'-nucleotidase domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A1W2P799
    Related
    ENSMUSP00000151537.2, ENSMUST00000218802.2
    Conserved Domains (1) summary
    pfam05761
    Location:18 → 451
    5_nucleotid; 5' nucleotidase family

RNA

  1. XR_003948574.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHB1.1 GenPept UniProtKB/Swiss-Prot:Q3UHB1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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