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Ncln nicalin [ Mus musculus (house mouse) ]

Gene ID: 103425, updated on 11-Apr-2024

Summary

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Official Symbol
Nclnprovided by MGI
Official Full Name
nicalinprovided by MGI
Primary source
MGI:MGI:1926081
See related
Ensembl:ENSMUSG00000020238 AllianceGenome:MGI:1926081
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3100002P13Rik
Summary
Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be part of protein-containing complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in neural retinal epithelium; retina inner nuclear layer; retina nuclear layer; and retina outer nuclear layer. Orthologous to human NCLN (nicalin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 185.0), duodenum adult (RPKM 173.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81322289..81333178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81486455..81496954, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear factor I/C Neighboring gene predicted gene, 51811 Neighboring gene STARR-positive B cell enhancer ABC_E577 Neighboring gene CUGBP, Elav-like family member 5 Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80973115-80973298 Neighboring gene guanine nucleotide binding protein, alpha 15 Neighboring gene STARR-positive B cell enhancer ABC_E11449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. Cukier IH, et al. FEBS Lett, 2007 Apr 17. PMID 17408621
  2. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in multi-pass transmembrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of multi-pass translocon complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BOS complex subunit NCLN
Names
nicalin homolog
nicastrin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134009.3 → NP_598770.1  BOS complex subunit NCLN precursor

    See identical proteins and their annotated locations for NP_598770.1

    Status: PROVISIONAL

    Source sequence(s)
    BC019501
    Consensus CDS
    CCDS36000.1
    UniProtKB/Swiss-Prot
    Q8C7Y4, Q8VCM8, Q9CX81
    Related
    ENSMUSP00000020463.8, ENSMUST00000020463.14
    Conserved Domains (1) summary
    cd03882
    Location:130 → 429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81322289..81333178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313762.3 → XP_017169251.1  BOS complex subunit NCLN isoform X1

    UniProtKB/TrEMBL
    D3YU17
    Related
    ENSMUSP00000112744.2, ENSMUST00000118498.8
    Conserved Domains (1) summary
    cd03882
    Location:127 → 429
    M28_nicalin_like; M28 Zn-Peptidase Nicalin, Nicastrin-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VCM8.2 GenPept UniProtKB/Swiss-Prot:Q8VCM8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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