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Csnk1g2 casein kinase 1, gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 103236, updated on 21-Apr-2024

Summary

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Official Symbol
Csnk1g2provided by MGI
Official Full Name
casein kinase 1, gamma 2provided by MGI
Primary source
MGI:MGI:1920014
See related
Ensembl:ENSMUSG00000003345 AllianceGenome:MGI:1920014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810429I12Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Wnt signaling pathway; positive regulation of canonical Wnt signaling pathway; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in brain; genitourinary system; and skin. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 317.9), colon adult (RPKM 106.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80458465..80476605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80622676..80640771)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene secretory carrier membrane protein 4 Neighboring gene microRNA 6912 Neighboring gene predicted gene, 31298 Neighboring gene BTB domain containing 2 Neighboring gene predicted gene, 51810 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene MAP kinase-interacting serine/threonine kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. Li D, et al. Elife, 2020 Nov 18. PMID 33206046, Free PMC Article
  2. Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Mishra SK, et al. Oncogene, 2004 May 27. PMID 15077195
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CKI-gamma2 could further potentiate the ER corepressive function of MTA1s. Kinase dead CK1-gamma2 could not repress estrogen-induced ER transactivation functions.
    Title: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase I isoform gamma-2; casein kinase I
Names
CKI-gamma 2
NP_001153063.1
NP_598763.1
XP_006513074.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159591.1 → NP_001153063.1  casein kinase I isoform gamma-2 isoform 2

    See identical proteins and their annotated locations for NP_001153063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon and lacks an in-frame internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK132871, AK152413, CF612914
    Consensus CDS
    CCDS48638.1
    UniProtKB/Swiss-Prot
    Q8BVP5
    Related
    ENSMUSP00000082560.6, ENSMUST00000085435.7
    Conserved Domains (2) summary
    cd14126
    Location:45 → 332
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:332 → 374
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. NM_134002.2 → NP_598763.1  casein kinase I isoform gamma-2 isoform 1

    See identical proteins and their annotated locations for NP_598763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC152410, AK077076, AK132871, AK152413, CF612914
    Consensus CDS
    CCDS24029.1
    UniProtKB/TrEMBL
    Q99K78
    Related
    ENSMUSP00000078706.7, ENSMUST00000079773.14
    Conserved Domains (3) summary
    COG0515
    Location:45 → 356
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:45 → 359
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:359 → 401
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80458465..80476605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513011.3 → XP_006513074.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006513074.1

    UniProtKB/Swiss-Prot
    Q8BVP5
    Conserved Domains (2) summary
    cd14126
    Location:45 → 332
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:332 → 374
    CK1gamma_C; Casein kinase 1 gamma C terminal

RNA

  1. XR_001779401.2 RNA Sequence

  2. XR_380333.4 RNA Sequence

  3. XR_003948572.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVP5.1 GenPept UniProtKB/Swiss-Prot:Q8BVP5

Gene LinkOut

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