Traf3ip2 TRAF3 interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Traf3ip2provided by MGI
Official Full Name: TRAF3 interacting protein 2provided by MGI
Primary source: MGI:MGI:2143599
See related: Ensembl:ENSMUSG00000019842 AllianceGenome:MGI:2143599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Act1; CIKS
Summary: Enables signaling receptor binding activity and ubiquitin protein ligase activity. Involved in several processes, including cell surface receptor signaling pathway; hematopoietic or lymphoid organ development; and leukocyte homeostasis. Acts upstream of or within B cell apoptotic process and humoral immune response. Is active in cytoplasmic vesicle and nucleus. Used to study Sjogren's syndrome; atopic dermatitis; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis and psoriasis 13. Orthologous to human TRAF3IP2 (TRAF3 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Act1 (Gene ID:109776) and Traf3ip2 (Gene ID:103213) share the Act1 symbol/alias in common. Act1 is a widely used alternative name for adapter protein CIKS (Traf3ip2), which can be confused with the official symbol for Act1, actin related gene 1 (Act1). [15 Oct 2019]
Expression: Broad expression in colon adult (RPKM 15.9), ovary adult (RPKM 14.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 20.86 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (39488930..39531303)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (39612934..39655307)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NF-kappaB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer.
Title: NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer.
ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity.
Title: ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity.
Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune Diseases.
Title: Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune Diseases.
TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice.
Title: TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice.
Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.
Title: Diabetes induces IL-17A-Act1-FADD-dependent retinal endothelial cell death and capillary degeneration.
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.
Title: Act1 is a negative regulator in T and B cells via direct inhibition of STAT3.
Study shows that miR-215 regulates the Act1/IL-17RA pathway and represses the expression of Act1 protein in oxygen glucose deprivation/reperfusion-treated N2a cells and an middle cerebral artery occlusion mouse model of ischemic stroke.
Title: Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling.
knock-out mice develop spontaneous IL-22-dependent skin inflammation
Title: The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.
Targeted Act1 deficiency in epithelial cells resulted in a marked delay in worm expulsion.
Title: Epithelial cell-specific Act1 adaptor mediates interleukin-25-dependent helminth expulsion through expansion of Lin(-)c-Kit(+) innate cell population.
IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner.
Title: IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Gene trapped (4)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI426748 (e-PCR)
- UniSTS:159972

AI429613 (e-PCR)
- UniSTS:159973

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell affinity maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell mediated immunity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in CD40 signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T-helper 17 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cytokine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to interleukin-17	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eosinophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eosinophil mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of T cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IDA Inferred from Direct Assay more info	PubMed
involved_in humoral immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info	PubMed
involved_in interleukin-17-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-17-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17A-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-17A-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-17A-mediated signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte activation involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mucus secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to P-body	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in skin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transitional two stage B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin ligase TRAF3IP2

Names: E3 ubiquitin-protein ligase CIKS; adapter protein CIKS; connection to IKK and SAPK/JNK; nuclear factor NF-kappa-B activator 1

NP_598761.2

EC 2.3.2.27

XP_011241407.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134000.3 → NP_598761.2 E3 ubiquitin ligase TRAF3IP2

See identical proteins and their annotated locations for NP_598761.2

Status: VALIDATED

Source sequence(s)

AC160403

Consensus CDS

CCDS23789.1

UniProtKB/Swiss-Prot

Q8BH33, Q8N7N6

UniProtKB/TrEMBL

Q8C0E5

Related

ENSMUSP00000019987.7, ENSMUST00000019987.7

Conserved Domains (2) summary

PRK10263
Location:217 → 373

PRK10263; DNA translocase FtsK; Provisional

pfam08357
Location:391 → 533

SEFIR; SEFIR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

39488930..39531303

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243105.2 → XP_011241407.1 E3 ubiquitin ligase TRAF3IP2 isoform X1

UniProtKB/TrEMBL

Q8C0E5

Conserved Domains (2) summary

PRK10263
Location:245 → 401

PRK10263; DNA translocase FtsK; Provisional

pfam08357
Location:419 → 561

SEFIR; SEFIR domain