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TNIP1 TNFAIP3 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 10318, updated on 3-Apr-2024

Summary

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Official Symbol
TNIP1provided by HGNC
Official Full Name
TNFAIP3 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16903
See related
Ensembl:ENSG00000145901 MIM:607714; AllianceGenome:HGNC:16903
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VAN; NAF1; ABIN-1; nip40-1
Summary
This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Expression
Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See TNIP1 in Genome Data Viewer
Location:
5q33.1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (151029943..151087685, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (151566421..151624171, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (150409504..150467246, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378228 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:150376236-150376402 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:150401597-150402796 Neighboring gene glutathione peroxidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150435866-150436392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150445954-150446696 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150446697-150447439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16518 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150460705-150461415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23433 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23435 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:150473600-150474799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23438 Neighboring gene annexin A6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:150503406-150503906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23443 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:150537501-150538357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23444 Neighboring gene uncharacterized LOC107986463 Neighboring gene platelet derived growth factor receptor like 2, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus. Azhdari S, et al. Lupus, 2022 Jul. PMID 35475371
  2. Association of TNIP1 polymorphisms with hepatocellular carcinoma in a Northwest Chinese Han population. Shi Y, et al. Medicine (Baltimore), 2021 Mar 26. PMID 33761643, Free PMC Article
  3. Enhanced Wound Healing- and Inflammasome-Associated Gene Expression in TNFAIP3-Interacting Protein 1- (TNIP1-) Deficient HaCaT Keratinocytes Parallels Reduced Reepithelialization. Shamilov R, et al. Mediators Inflamm, 2020. PMID 32377162, Free PMC Article
  4. Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three-Dimensional Chromatin Network. Pasula S, et al. Arthritis Rheumatol, 2020 May. PMID 31804013, Free PMC Article
  5. TNIP1-mediated TNF-α/NF-κB signalling cascade sustains glioma cell proliferation. Lei Q, et al. J Cell Mol Med, 2020 Jan. PMID 31691497, Free PMC Article

See all (177) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study.
    Title: TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study.
  2. The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.
    Title: The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.
  3. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
    Title: TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.
  4. TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
    Title: TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.
  5. Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
    Title: Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.
  6. ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
    Title: ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.
  7. Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus.
    Title: Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus.
  8. Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.
    Title: Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.
  9. A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-kappaB signaling in activated T cells.
    Title: A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.
  10. ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
    Title: ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (94)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
EBI GWAS Catalog
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
EBI GWAS Catalog
Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.
EBI GWAS Catalog
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
EBI GWAS Catalog
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef Nef-associated factor 1 (Naf1) binds to HIV-1 Nef through amino acids 94-412 of Naf1; overexpression of Naf1 in 293T cells increases CD4 expression, and Nef suppresses this activity of Naf1 to downregulate CD4 PubMed
matrix gag VAN is efficiently incorporated into HIV-1 virions, presumably as a result of binding to HIV-1 Matrix PubMed
gag The C-terminus (amino acids 468-637) of virion-associated matrix-interacting protein (VAN) binds to HIV-1 Matrix and has been proposed to play a role in the nuclear import of the HIV-1 preintegration complex PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein deubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
TNFAIP3-interacting protein 1
Names
A20-binding inhibitor of NF-kappa-B activation 1
HIV-1 Nef-interacting protein
Nef-associated factor 1 SNP
virion-associated nuclear shuttling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030590.1 RefSeqGene

    Range
    11627..62716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001252385.2 → NP_001239314.1  TNFAIP3-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001239314.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB252973, AK074400, AK303573, AW589284
    Consensus CDS
    CCDS75359.1
    UniProtKB/TrEMBL
    A0A0A0MRZ4, B7Z8K2
    Related
    ENSP00000374029.3, ENST00000389378.6
    Conserved Domains (5) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367 → 379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452 → 500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001252386.2 → NP_001239315.1  TNFAIP3-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001239315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, one of which is the use of a downstream start codon. Isoform 2 has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB252975, AK074400, AW589284, BX640647
    Consensus CDS
    CCDS58982.1
    UniProtKB/TrEMBL
    B7Z5B0
    Related
    ENSP00000429891.1, ENST00000520931.5
    Conserved Domains (4) summary
    cd16269
    Location:314 → 326
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:399 → 447
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:161 → 198
    MreC; rod shape-determining protein MreC
    cl20817
    Location:245 → 346
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_001252390.2 → NP_001239319.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239319.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252970, AC008641, AK074400, AK290999, AW589284
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
    UniProtKB/TrEMBL
    A8K4N4
    Related
    ENSP00000428187.1, ENST00000522226.5
    Conserved Domains (2) summary
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298 → 538
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001252391.2 → NP_001239320.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001239320.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252970, AK074400, AW589284, DA643531
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
    UniProtKB/TrEMBL
    A8K4N4
    Related
    ENSP00000317891.7, ENST00000315050.11
    Conserved Domains (2) summary
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298 → 538
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_001252392.2 → NP_001239321.1  TNFAIP3-interacting protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001239321.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
    Source sequence(s)
    AB252971, AK074400, AW589284, DA643531
    Consensus CDS
    CCDS58985.1
    UniProtKB/TrEMBL
    A4F1Y0
    Related
    ENSP00000428243.1, ENST00000523338.5
    Conserved Domains (6) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    pfam15619
    Location:334 → 507
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cd16269
    Location:367 → 379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452 → 500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. NM_001252393.2 → NP_001239322.1  TNFAIP3-interacting protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001239322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses two alternate splice sites in the 3' coding region, compared to variant 1. The resulting isoform (4) is longer and contains a distinct C-terminus, compared to isoform 1. Variants 6 and 7 encode the same protein (isoform 4).
    Source sequence(s)
    AB252973, AK074400, AW589284
    Consensus CDS
    CCDS58985.1
    UniProtKB/TrEMBL
    A4F1Y0
    Related
    ENSP00000430971.1, ENST00000518977.5
    Conserved Domains (6) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    pfam15619
    Location:334 → 507
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cd16269
    Location:367 → 379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452 → 500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  7. NM_001258454.2 → NP_001245383.1  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001245383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AC008641
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
    UniProtKB/TrEMBL
    A8K4N4
    Conserved Domains (2) summary
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298 → 538
    SMC_N; RecF/RecN/SMC N terminal domain

  8. NM_001258455.1 → NP_001245384.1  TNFAIP3-interacting protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001245384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an exon and uses an alternate splice site in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 5) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB177543, AC008641
    Consensus CDS
    CCDS58984.1
    UniProtKB/TrEMBL
    A8K4N4
    Related
    ENSP00000431105.1, ENST00000523200.5
    Conserved Domains (3) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298 → 529
    SMC_N; RecF/RecN/SMC N terminal domain

  9. NM_001258456.1 → NP_001245385.1  TNFAIP3-interacting protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks two exons in the 3' coding region which results in a frameshift compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB177544, AC008641
    Consensus CDS
    CCDS58983.1
    UniProtKB/TrEMBL
    E7EMV7
    Related
    ENSP00000429912.1, ENST00000524280.5
    Conserved Domains (6) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367 → 379
    GBP_C; coiled coil [structural motif]
    cl02415
    Location:323 → 365
    DUF922; Bacterial protein of unknown function (DUF922)
    cl15254
    Location:452 → 500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  10. NM_001364486.2 → NP_001351415.1  TNFAIP3-interacting protein 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' and 3' UTRs and coding sequence and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (7) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008641
    UniProtKB/TrEMBL
    B7Z5B0
    Conserved Domains (2) summary
    cl19252
    Location:161 → 198
    MreC; rod shape-determining protein MreC
    cl25732
    Location:245 → 485
    SMC_N; RecF/RecN/SMC N terminal domain

  11. NM_001364487.2 → NP_001351416.1  TNFAIP3-interacting protein 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks an alternate in-frame exon and uses an alternate splice junction compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008641
    Consensus CDS
    CCDS58984.1
    UniProtKB/TrEMBL
    A8K4N4
    Related
    ENSP00000483944.1, ENST00000610535.5
    Conserved Domains (3) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298 → 529
    SMC_N; RecF/RecN/SMC N terminal domain

  12. NM_006058.5 → NP_006049.3  TNFAIP3-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_006049.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (3) is longer and contains a distinct Cz-terminus, compared to isoform 1. Variants 3, 4, 5 and 8 encode the same protein (isoform 3).
    Source sequence(s)
    AB252972, AK074400, AW589284
    Consensus CDS
    CCDS34280.1
    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3
    UniProtKB/TrEMBL
    A8K4N4
    Related
    ENSP00000430760.1, ENST00000521591.6
    Conserved Domains (2) summary
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl25732
    Location:298 → 538
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    151029943..151087685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416627.1 → XP_047272583.1  TNFAIP3-interacting protein 1 isoform X8

    Related
    ENSP00000427854.1, ENST00000519339.5

  2. XM_047416623.1 → XP_047272579.1  TNFAIP3-interacting protein 1 isoform X4

  3. XM_047416625.1 → XP_047272581.1  TNFAIP3-interacting protein 1 isoform X6

  4. XM_047416615.1 → XP_047272571.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  5. XM_047416617.1 → XP_047272573.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  6. XM_047416616.1 → XP_047272572.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  7. XM_047416618.1 → XP_047272574.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  8. XM_047416626.1 → XP_047272582.1  TNFAIP3-interacting protein 1 isoform X6

  9. XM_047416619.1 → XP_047272575.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  10. XM_047416624.1 → XP_047272580.1  TNFAIP3-interacting protein 1 isoform X5

  11. XM_047416622.1 → XP_047272578.1  TNFAIP3-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MRZ4

  12. XM_006714752.4 → XP_006714815.1  TNFAIP3-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    A4F1Y0
    Conserved Domains (5) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367 → 379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452 → 500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  13. XM_005268355.3 → XP_005268412.1  TNFAIP3-interacting protein 1 isoform X3

    See identical proteins and their annotated locations for XP_005268412.1

    UniProtKB/TrEMBL
    A0A0A0MRZ4, B7Z8K2
    Conserved Domains (5) summary
    pfam15058
    Location:14 → 149
    Speriolin_N; Speriolin N terminus
    cd16269
    Location:367 → 379
    GBP_C; coiled coil [structural motif]
    cl15254
    Location:452 → 500
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    cl19252
    Location:214 → 251
    MreC; rod shape-determining protein MreC
    cl20817
    Location:298 → 399
    GBP_C; Guanylate-binding protein, C-terminal domain

  14. XM_047416620.1 → XP_047272576.1  TNFAIP3-interacting protein 1 isoform X2

  15. XM_047416621.1 → XP_047272577.1  TNFAIP3-interacting protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    151566421..151624171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054351427.1 → XP_054207402.1  TNFAIP3-interacting protein 1 isoform X8

  2. XM_054351422.1 → XP_054207397.1  TNFAIP3-interacting protein 1 isoform X4

  3. XM_054351424.1 → XP_054207399.1  TNFAIP3-interacting protein 1 isoform X6

  4. XM_054351414.1 → XP_054207389.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  5. XM_054351416.1 → XP_054207391.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  6. XM_054351415.1 → XP_054207390.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  7. XM_054351425.1 → XP_054207400.1  TNFAIP3-interacting protein 1 isoform X6

  8. XM_054351417.1 → XP_054207392.1  TNFAIP3-interacting protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A4F1W8, A4F1W9, A4F1X2, A4F1X4, A4F1X5, A4F1X6, A4F1X7, A4F1X9, B7Z699, E7EPY1, E7ET96, O76008, Q05KP3, Q05KP4, Q15025, Q6N077, Q96EL9, Q99833, Q9H1J3

  9. XM_054351423.1 → XP_054207398.1  TNFAIP3-interacting protein 1 isoform X5

  10. XM_054351421.1 → XP_054207396.1  TNFAIP3-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MRZ4

  11. XM_054351426.1 → XP_054207401.1  TNFAIP3-interacting protein 1 isoform X7

  12. XM_054351420.1 → XP_054207395.1  TNFAIP3-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A0A0MRZ4

  13. XM_054351418.1 → XP_054207393.1  TNFAIP3-interacting protein 1 isoform X2

  14. XM_054351419.1 → XP_054207394.1  TNFAIP3-interacting protein 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15025.2 GenPept UniProtKB/Swiss-Prot:Q15025

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