U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pan2 PAN2 poly(A) specific ribonuclease subunit [ Mus musculus (house mouse) ]

Gene ID: 103135, updated on 18-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Pan2provided by MGI
Official Full Name
PAN2 poly(A) specific ribonuclease subunitprovided by MGI
Primary source
MGI:MGI:1918984
See related
Ensembl:ENSMUSG00000005682 AllianceGenome:MGI:1918984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Usp52; mKIAA0710; 1200014O24Rik
Summary
Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, exonucleolytic. Located in P-body. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 19.4), limb E14.5 (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 D3; 10 76.51 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128135106..128157227)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128303333..128321358)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5199 Neighboring gene apolipoprotein F Neighboring gene signal transducer and activator of transcription 2 Neighboring gene STARR-seq mESC enhancer starr_28274 Neighboring gene STARR-positive B cell enhancer ABC_E194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127740631-127740818 Neighboring gene interleukin 23, alpha subunit p19 Neighboring gene predicted gene, 23241 Neighboring gene canopy FGF signaling regulator 2 Neighboring gene STARR-positive B cell enhancer ABC_E9813 Neighboring gene STARR-positive B cell enhancer ABC_E1134 Neighboring gene STARR-positive B cell enhancer ABC_E11467 Neighboring gene citrate synthase Neighboring gene predicted gene, 23182

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of zygotic genome activation-dependent maternal mRNA clearance in mouse. Sha QQ, et al. Nucleic Acids Res, 2020 Jan 24. PMID 31777931, Free PMC Article
  2. Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells. Zheng D, et al. J Cell Biol, 2008 Jul 14. PMID 18625844, Free PMC Article
  3. Discovery of novel protein partners of the transcription factor FOXL2 provides insights into its physiopathological roles. L'Hôte D, et al. Hum Mol Genet, 2012 Jul 15. PMID 22544055
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PAN complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PAN complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
PAN2-PAN3 deadenylation complex catalytic subunit Pan2
Names
AN2 polyA specific ribonuclease subunit homolog
PAB-dependent poly(A)-specific ribonuclease subunit 2
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
PAB1P-dependent poly(A)-nuclease
PAN deadenylation complex catalytic subunit 2
PAN2 polyA specific ribonuclease subunit homolog
inactive ubiquitin carboxyl-terminal hydrolase 52
poly(A)-nuclease deadenylation complex subunit 2
ubiquitin specific peptidase 52
ubiquitin specific protease 52
NP_001239255.1
NP_001239256.1
NP_001345751.1
NP_598753.1
XP_006513048.1
XP_006513049.1
XP_006513050.1
XP_006513051.1
XP_006513052.1
XP_006513053.1
XP_036011343.1
XP_036011344.1
XP_036011345.1
XP_036011346.1
XP_036011347.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252326.1 → NP_001239255.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2

    See identical proteins and their annotated locations for NP_001239255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC135859, AK004773, BC079841, CF170307
    Consensus CDS
    CCDS88107.1
    UniProtKB/Swiss-Prot
    Q8BGF7
    Related
    ENSMUSP00000151216.2, ENSMUST00000218315.2
    Conserved Domains (4) summary
    cd06143
    Location:965 → 1138
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:501 → 911
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:516 → 888
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001252327.1 → NP_001239256.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AC135859, AK004773, AK157800, BG086688
    Consensus CDS
    CCDS88108.1
    UniProtKB/Swiss-Prot
    Q8BGF7
    Related
    ENSMUSP00000151874.2, ENSMUST00000219721.2
    Conserved Domains (4) summary
    cd06143
    Location:947 → 1120
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:483 → 893
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:498 → 870
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:75 → 339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. NM_001358822.1 → NP_001345751.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC135859, AK004773, AK047887, CN527165, CX566326
    Related
    ENSMUST00000218496.2
    Conserved Domains (3) summary
    cd06143
    Location:836 → 1009
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:362 → 782
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl25539
    Location:21 → 218
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. NM_133992.3 → NP_598753.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1

    See identical proteins and their annotated locations for NP_598753.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
    Source sequence(s)
    AC135859, AK004773, AK047887
    Consensus CDS
    CCDS24271.1
    UniProtKB/Swiss-Prot
    Q3TZK5, Q68FH6, Q6ZQ63, Q8BGF7
    Related
    ENSMUSP00000005825.7, ENSMUST00000005825.8
    Conserved Domains (4) summary
    cd06143
    Location:974 → 1147
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    cd02672
    Location:501 → 920
    Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam13423
    Location:516 → 897
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl02567
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128135106..128157227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155450.1 → XP_036011343.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X1

    Conserved Domains (3) summary
    cd06143
    Location:979 → 1152
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516 → 902
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006512985.4 → XP_006513048.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X1

    Conserved Domains (3) summary
    cd06143
    Location:979 → 1152
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516 → 902
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006512989.3 → XP_006513052.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X6

    Conserved Domains (3) summary
    pfam13423
    Location:516 → 902
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl10012
    Location:979 → 1092
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_006512988.4 → XP_006513051.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X4

    Conserved Domains (3) summary
    cd06143
    Location:970 → 1143
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516 → 893
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_036155453.1 → XP_036011346.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X8

    Conserved Domains (3) summary
    pfam13423
    Location:516 → 893
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl10012
    Location:970 → 1083
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_006512987.4 → XP_006513050.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X3

    Conserved Domains (3) summary
    cd06143
    Location:975 → 1148
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516 → 898
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_036155452.1 → XP_036011345.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X7

    Conserved Domains (3) summary
    pfam13423
    Location:516 → 898
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl10012
    Location:975 → 1088
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_036155451.1 → XP_036011344.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X5

    Conserved Domains (3) summary
    cd06143
    Location:966 → 1139
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516 → 889
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  9. XM_006512986.4 → XP_006513049.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X2

    Conserved Domains (3) summary
    cd06143
    Location:978 → 1151
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:516 → 901
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:75 → 357
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  10. XM_006512990.4 → XP_006513053.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X9

    Conserved Domains (3) summary
    cd06143
    Location:840 → 1013
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:377 → 763
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:21 → 218
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  11. XM_036155454.1 → XP_036011347.1  PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X10

    Conserved Domains (3) summary
    cd06143
    Location:835 → 1008
    PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2
    pfam13423
    Location:377 → 758
    UCH_1; Ubiquitin carboxyl-terminal hydrolase
    cl29593
    Location:21 → 218
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_380330.4 RNA Sequence

  2. XR_380328.3 RNA Sequence

  3. XR_001779394.3 RNA Sequence

  4. XR_380329.4 RNA Sequence

  5. XR_003948564.2 RNA Sequence

  6. XR_004936004.1 RNA Sequence

  7. XR_003948567.2 RNA Sequence

  8. XR_004936003.1 RNA Sequence

  9. XR_004936005.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGF7.1 GenPept UniProtKB/Swiss-Prot:Q8BGF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous