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Slc6a15 solute carrier family 6 (neurotransmitter transporter), member 15 [ Mus musculus (house mouse) ]

Gene ID: 103098, updated on 11-Apr-2024

Summary

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Official Symbol
Slc6a15provided by MGI
Official Full Name
solute carrier family 6 (neurotransmitter transporter), member 15provided by MGI
Primary source
MGI:MGI:2143484
See related
Ensembl:ENSMUSG00000019894 AllianceGenome:MGI:2143484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
v7-3
Summary
Enables proline:sodium symporter activity. Involved in leucine transport and proline transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in alimentary system; central nervous system; dorsal root ganglion; metanephros; and sensory organ. Orthologous to human SLC6A15 (solute carrier family 6 member 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 15.2), cerebellum adult (RPKM 9.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D1; 10 53.98 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (103203320..103255240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (103367808..103419379)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34298 Neighboring gene ALX homeobox 1 Neighboring gene leucine-rich repeats and IQ motif containing 1 Neighboring gene predicted gene, 25376 Neighboring gene STARR-seq mESC enhancer starr_27747 Neighboring gene STARR-seq mESC enhancer starr_27748 Neighboring gene STARR-seq mESC enhancer starr_27749 Neighboring gene STARR-seq mESC enhancer starr_27750 Neighboring gene STARR-seq mESC enhancer starr_27751 Neighboring gene RIKEN cDNA 6430590A10 gene Neighboring gene STARR-seq mESC enhancer starr_27752 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27753 Neighboring gene predicted gene, 25143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons. Schraut KG, et al. Eur J Neurosci, 2021 Jan. PMID 33007132
  2. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Santarelli S, et al. Stress, 2016. PMID 26585320
  3. The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior. Santarelli S, et al. J Psychiatr Res, 2015 Sep. PMID 26228428
  4. Involvement of the neutral amino acid transporter SLC6A15 and leucine in obesity-related phenotypes. Drgonova J, et al. PLoS One, 2013. PMID 24023709, Free PMC Article
  5. B(0)AT2 (SLC6A15) is localized to neurons and astrocytes, and is involved in mediating the effect of leucine in the brain. Hägglund MG, et al. PLoS One, 2013. PMID 23505546, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
    Title: Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons.
  2. Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress.
    Title: Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility.
  3. Slc6a15 plays a role in modulating emotional behavior, possibly mediated by its impact on glutamatergic neurotransmission.
    Title: SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.
  4. SLC6A15 regulates the activity of the brain glutamatergic system through the proline-glutamate biosynthesis pathway, affecting hippocampal neurochemistry and consequently behavior.
    Title: The amino acid transporter SLC6A15 is a regulator of hippocampal neurochemistry and behavior.
  5. Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests
    Title: Deletion of v7-3 (SLC6A15) transporter allows assessment of its roles in synaptosomal proline uptake, leucine uptake and behaviors.
  6. The structure and function of B0AT2 are reported.
    Title: The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables branched-chain amino acid:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables branched-chain amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neutral L-amino acid:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables proline:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proline:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-leucine transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurotransmitter transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in proline transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sodium-dependent neutral amino acid transporter B(0)AT2
Names
B0AT2 protein
orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
orphan transporter v7-3
solute carrier family 6 member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252330.1 → NP_001239259.1  sodium-dependent neutral amino acid transporter B(0)AT2

    See identical proteins and their annotated locations for NP_001239259.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR, compared to variant c. Variants a, b and c encode the same protein.
    Source sequence(s)
    AW124505, BC076593
    Consensus CDS
    CCDS24156.1
    UniProtKB/Swiss-Prot
    Q333Y0, Q8BG16
    Related
    ENSMUSP00000136676.2, ENSMUST00000179636.3
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

  2. NM_001358821.1 → NP_001345750.1  sodium-dependent neutral amino acid transporter B(0)AT2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) represents the longest transcript. Variants a, b and c encode the same protein.
    Source sequence(s)
    AW124505, BC076593, CF736974, CN460271
    Consensus CDS
    CCDS24156.1
    UniProtKB/Swiss-Prot
    Q333Y0, Q8BG16
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

  3. NM_175328.3 → NP_780537.1  sodium-dependent neutral amino acid transporter B(0)AT2

    See identical proteins and their annotated locations for NP_780537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) differs in the 5' UTR, compared to variant c. Variants a, b and c encode the same protein.
    Source sequence(s)
    AW124505, AY149280, BC076593
    Consensus CDS
    CCDS24156.1
    UniProtKB/Swiss-Prot
    Q333Y0, Q8BG16
    Related
    ENSMUSP00000073829.5, ENSMUST00000074204.12
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    103203320..103255240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155449.1 → XP_036011342.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

    UniProtKB/Swiss-Prot
    Q333Y0, Q8BG16
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

  2. XM_006512983.5 → XP_006513046.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

    See identical proteins and their annotated locations for XP_006513046.1

    UniProtKB/Swiss-Prot
    Q333Y0, Q8BG16
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain

  3. XM_006512984.5 → XP_006513047.1  sodium-dependent neutral amino acid transporter B(0)AT2 isoform X1

    See identical proteins and their annotated locations for XP_006513047.1

    UniProtKB/Swiss-Prot
    Q333Y0, Q8BG16
    Conserved Domains (1) summary
    cd11522
    Location:61 → 640
    SLC6sbd_SBAT1; Sodium-coupled branched-chain amino-acid transporter 1; solute-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG16.1 GenPept UniProtKB/Swiss-Prot:Q8BG16

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