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Septin10 septin 10 [ Mus musculus (house mouse) ]

Gene ID: 103080, updated on 11-Apr-2024

Summary

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Official Symbol
Septin10provided by MGI
Official Full Name
septin 10provided by MGI
Primary source
MGI:MGI:1918110
See related
Ensembl:ENSMUSG00000019917 AllianceGenome:MGI:1918110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sept10; 4921515A04Rik; 9430099J10Rik
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cellular protein localization and cytoskeleton-dependent cytokinesis. Predicted to act upstream of or within cell division. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Orthologous to human SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 14.3), bladder adult (RPKM 8.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 B4; 10 29.48 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (58977446..59057322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59141624..59221500, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26764 Neighboring gene zinc finger CCCH type containing 11A pseudogene Neighboring gene SH3 domain containing ring finger 3 Neighboring gene STARR-seq mESC enhancer starr_26766 Neighboring gene predicted gene, 53588 Neighboring gene STARR-positive B cell enhancer ABC_E6855 Neighboring gene predicted gene, 23223 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene predicted gene, 36257 Neighboring gene predicted gene, 40669

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Localization of septin proteins in the mouse cochlea. Yoshida A, et al. Hear Res, 2012 Jul. PMID 22575789, Free PMC Article
  2. Androglobin, a chimeric mammalian globin, is required for male fertility. Keppner A, et al. Elife, 2022 Jun 14. PMID 35700329, Free PMC Article
  3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm annulus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
septin-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024910.4 → NP_001020081.2  septin-10 isoform 1

    See identical proteins and their annotated locations for NP_001020081.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC153941, AC159909
    Consensus CDS
    CCDS88009.1
    UniProtKB/Swiss-Prot
    Q7TSA5, Q8C650
    UniProtKB/TrEMBL
    A0A1W2P6J7
    Related
    ENSMUSP00000151293.2, ENSMUST00000220156.2
    Conserved Domains (3) summary
    cd01850
    Location:36 → 304
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:17 → 389
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl20817
    Location:333 → 389
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001024911.3 → NP_001020082.1  septin-10 isoform 2

    See identical proteins and their annotated locations for NP_001020082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 3' coding region and 3' UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC153941
    Consensus CDS
    CCDS48566.1
    UniProtKB/Swiss-Prot
    Q7TSA5, Q8C650
    UniProtKB/TrEMBL
    A0A0R4J233
    Related
    ENSMUSP00000129023.2, ENSMUST00000165971.3
    Conserved Domains (3) summary
    cd01850
    Location:36 → 304
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:17 → 389
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl20817
    Location:333 → 389
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_001379063.1 → NP_001365992.1  septin-10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AC153941, AC159909
    UniProtKB/Swiss-Prot
    Q7TSA5, Q8C650
    Conserved Domains (2) summary
    PTZ00121
    Location:274 → 426
    PTZ00121; MAEBL; Provisional
    cd01850
    Location:40 → 308
    CDC_Septin; CDC/Septin GTPase family

  4. NM_001379064.1 → NP_001365993.1  septin-10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153941
    UniProtKB/Swiss-Prot
    Q7TSA5, Q8C650
    Conserved Domains (2) summary
    cd01850
    Location:40 → 308
    CDC_Septin; CDC/Septin GTPase family
    COG3064
    Location:322 → 405
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

  5. NM_001379065.1 → NP_001365994.1  septin-10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC153941
    UniProtKB/Swiss-Prot
    Q7TSA5, Q8C650
    Conserved Domains (2) summary
    cd01850
    Location:40 → 308
    CDC_Septin; CDC/Septin GTPase family
    COG3064
    Location:322 → 405
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

  6. NM_001379066.1 → NP_001365995.1  septin-10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC153941
    UniProtKB/Swiss-Prot
    Q7TSA5, Q8C650
    Conserved Domains (2) summary
    cd01850
    Location:36 → 304
    CDC_Septin; CDC/Septin GTPase family
    COG3064
    Location:318 → 401
    TolA; Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis]

RNA

  1. NR_166449.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153941

  2. NR_166450.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153941

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    58977446..59057322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C650.1 GenPept UniProtKB/Swiss-Prot:Q8C650

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