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Ezhip EZH inhibitory protein [ Mus musculus (house mouse) ]

Gene ID: 102991, updated on 5-Mar-2024

Summary

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Official Symbol
Ezhipprovided by MGI
Official Full Name
EZH inhibitory proteinprovided by MGI
Primary source
MGI:MGI:2147968
See related
Ensembl:ENSMUSG00000073294 AllianceGenome:MGI:2147968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KIP75
Summary
Acts upstream of or within negative regulation of histone H3-K27 trimethylation and oocyte development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in axial skeleton and rib. Orthologous to human EZHIP (EZH inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 10.7) and testis adult (RPKM 0.7) See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 2.7 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (5993272..5995474, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (6081218..6083420, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26618 Neighboring gene STARR-seq mESC enhancer starr_46653 Neighboring gene nudix hydrolase 11 Neighboring gene ribosomal protein L19, pseudogene 12 Neighboring gene nuclear encoded rRNA 5S 2 Neighboring gene STARR-seq mESC enhancer starr_46654 Neighboring gene nudix hydrolase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Jain SU, et al. Nat Commun, 2019 May 13. PMID 31086175, Free PMC Article
  2. EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Ragazzini R, et al. Nat Commun, 2019 Aug 26. PMID 31451685, Free PMC Article
  3. CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism. Piunti A, et al. Sci Adv, 2019 Jul. PMID 31281901, Free PMC Article
  4. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of Ezhip (EZH inhibitory protein) in mice leads to a global increase in H3K27me2/3 deposition both during spermatogenesis and at late stages of oocyte maturation. This does not affect the initial number of follicles but is associated with a reduction of follicles in aging. Study uncovers Ezhip as a regulator of chromatin landscape in gametes.
    Title: EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.
  2. Study revealed that CXORF67 contains a highly conserved "K27M-like" sequence that is necessary and sufficient to inhibit PRC2 activity and reduce cellular H3K27me3 levels. Biochemical and cell-based studies demonstrate that CXORF67 functions as a K27M-like peptidyl inhibitor of PRC2. Therefore, study propose the name EZHIP (Enhancer of Zeste Homologs Inhibitory Protein) as a more descriptive for the function of CXORF67.
    Title: PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117813

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone methyltransferase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
EZH inhibitory protein
Names
K27M-like inhibitor of PRC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033211.3 → NP_001028383.2  EZH inhibitory protein isoform 2

    See identical proteins and their annotated locations for NP_001028383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    BX649475
    Consensus CDS
    CCDS52982.1
    UniProtKB/TrEMBL
    Q3UWZ4
    Related
    ENSMUSP00000099222.4, ENSMUST00000101698.4
    Conserved Domains (1) summary
    PRK06995
    Location:174 → 263
    flhF; flagellar biosynthesis protein FlhF

  2. NM_001166433.1 → NP_001159905.1  EZH inhibitory protein isoform 1

    See identical proteins and their annotated locations for NP_001159905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    BX649475
    Consensus CDS
    CCDS52981.1
    UniProtKB/Swiss-Prot
    B1B0V2, Q3TL73, Q3UWZ4, Q497U5
    Related
    ENSMUSP00000114041.2, ENSMUST00000117544.2
    Conserved Domains (2) summary
    PHA03247
    Location:128 → 502
    PHA03247; large tegument protein UL36; Provisional
    PRK06995
    Location:295 → 384
    flhF; flagellar biosynthesis protein FlhF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    5993272..5995474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1B0V2.1 GenPept UniProtKB/Swiss-Prot:B1B0V2

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