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TRAIP TRAF interacting protein [ Homo sapiens (human) ]

Gene ID: 10293, updated on 16-Apr-2024

Summary

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Official Symbol
TRAIPprovided by HGNC
Official Full Name
TRAF interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30764
See related
Ensembl:ENSG00000183763 MIM:605958; AllianceGenome:HGNC:30764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIP; SCKL9; RNF206
Summary
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 4.0), bone marrow (RPKM 2.3) and 23 other tissues See more
Orthologs
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Genomic context

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See TRAIP in Genome Data Viewer
Location:
3p21.31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (49828601..49856564, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (49858496..49886461, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (49866034..49893997, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14375 Neighboring gene Sharpr-MPRA regulatory region 10954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19876 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49844839-49845735 Neighboring gene inka box actin regulator 1 Neighboring gene microRNA 5193 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49848893-49849392 Neighboring gene ubiquitin like modifier activating enzyme 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19880 Neighboring gene CaM kinase like vesicle associated Neighboring gene RNA, 7SL, cytoplasmic 217, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49905159-49906091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49906092-49907023 Neighboring gene actin like 11, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT. Zheng Y, et al. Cancer Gene Ther, 2023 Jan. PMID 36064576, Free PMC Article
  2. The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome. Wu RA, et al. Trends Cell Biol, 2021 Feb. PMID 33317933, Free PMC Article
  3. TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer. Guo Z, et al. Biomed Pharmacother, 2020 Apr. PMID 31972358
  4. SUMOylation regulates nuclear localization and stability of TRAIP/RNF206. Park IS, et al. Biochem Biophys Res Commun, 2016 Feb 19. PMID 26820530
  5. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Harley ME, et al. Nat Genet, 2016 Jan. PMID 26595769, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
    Title: TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation.
  2. TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.
    Title: TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells.
  3. ZNF212 promotes genomic integrity through direct interaction with TRAIP.
    Title: ZNF212 promotes genomic integrity through direct interaction with TRAIP.
  4. Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.
    Title: Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT.
  5. TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
    Title: TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation.
  6. The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.
    Title: The Ubiquitin Ligase TRAIP: Double-Edged Sword at the Replisome.
  7. TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.
    Title: TRIP suppresses cell proliferation and invasion in choroidal melanoma via promoting the proteasomal degradation of Twist1.
  8. TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.
    Title: TRAIP promotes malignant behaviors and correlates with poor prognosis in liver cancer.
  9. TRAIP is important for the recruitment of NEIL3 but not FANCD2, and knockdown of TRAIP promotes FA/BRCA pathway activation. Interestingly, TRAIP is non-epistatic with both NEIL3 and FA pathways in psoralen-ICL repair, suggesting that TRAIP may function upstream of the two pathways.
    Title: Cooperation of the NEIL3 and Fanconi anemia/BRCA pathways in interstrand crosslink repair.
  10. present results, together with other recent findings, establish TRAIP as a master regulator of DNA helicase CMG unloading and the response of the replisome to obstacles
    Title: TRAIP is a master regulator of DNA interstrand crosslink repair.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Seckel syndrome 9
MedGen: C4225212 OMIM: 616777 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-DNA covalent cross-linking repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in replication fork processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in site of DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRAIP
Names
RING-type E3 ubiquitin transferase TRAIP
ring finger protein 206
NP_005870.2
XP_016861015.1
XP_047303196.1
XP_054200892.1
XP_054200893.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046695.1 RefSeqGene

    Range
    4996..32959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005879.3 → NP_005870.2  E3 ubiquitin-protein ligase TRAIP

    See identical proteins and their annotated locations for NP_005870.2

    Status: REVIEWED

    Source sequence(s)
    AC139451, BC019283, BQ446539, BX473682
    Consensus CDS
    CCDS2806.1
    UniProtKB/Swiss-Prot
    B5BU84, B5BUL3, O00467, Q9BWF2
    UniProtKB/TrEMBL
    A8K807
    Related
    ENSP00000328203.2, ENST00000331456.7
    Conserved Domains (2) summary
    cd16480
    Location:6 → 50
    RING-H2_TRAIP; RING finger, H2 subclass, found in TRAF-interacting protein (TRAIP) and similar proteins
    cl25732
    Location:68 → 279
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    49828601..49856564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005526.2 → XP_016861015.1  E3 ubiquitin-protein ligase TRAIP isoform X1

  2. XM_047447240.1 → XP_047303196.1  E3 ubiquitin-protein ligase TRAIP isoform X2

RNA

  1. XR_007094382.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    49858496..49886461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344917.1 → XP_054200892.1  E3 ubiquitin-protein ligase TRAIP isoform X1

  2. XM_054344918.1 → XP_054200893.1  E3 ubiquitin-protein ligase TRAIP isoform X2

RNA

  1. XR_008486627.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWF2.1 GenPept UniProtKB/Swiss-Prot:Q9BWF2

Gene LinkOut

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