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Gm21992 predicted gene 21992 [ Mus musculus (house mouse) ]

Gene ID: 102902673, updated on 10-Mar-2024

Summary

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Official Symbol
Gm21992provided by MGI
Official Full Name
predicted gene 21992provided by MGI
Primary source
MGI:MGI:5439461
See related
Ensembl:ENSMUSG00000096370 AllianceGenome:MGI:5439461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rbm14-rbm4
Summary
This locus represents naturally occurring readthrough transcription between the neighboring Rbm14 (RNA binding motif protein 14) and Rbm4 (RNA binding motif protein 4) genes. Alternative splicing results in multiple transcript variants, some of which encode fusion proteins that share sequence identity with each individual gene product. A slight modification was made to the summary, since not all variants are protein coding [provided by RefSeq, Jun 2018]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 24.4), CNS E14 (RPKM 23.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4792941..4861662, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4742913..4811634, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene microRNA 6986 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene STARR-positive B cell enhancer ABC_E1967 Neighboring gene RNA binding motif protein 4B Neighboring gene STARR-seq mESC enhancer starr_45357 Neighboring gene STARR-seq mESC enhancer starr_45358 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45361 Neighboring gene RNA binding motif protein 4 Neighboring gene STARR-seq mESC enhancer starr_45362 Neighboring gene STARR-seq mESC enhancer starr_45363 Neighboring gene RNA binding motif protein 14 Neighboring gene STARR-positive B cell enhancer ABC_E9452 Neighboring gene copper chaperone for superoxide dismutase Neighboring gene coiled-coil domain containing 87

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional pre- mRNA trans-splicing of coactivator CoAA and corepressor RBM4 during stem/progenitor cell differentiation. Brooks YS, et al. J Biol Chem, 2009 Jul 3. PMID 19416963, Free PMC Article
  2. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Readthrough Gm21992

Included genes: Rbm4, Rbm14

Homology

General protein information

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Preferred Names
Rbm14-Rbm4 readthrough
Names
Rbm14/Rbm4 fusion
transcriptional coactivator CoAZ

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290127.1 → NP_001277056.1  Rbm14-Rbm4 readthrough isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC141437, AC147618, EU287941
    UniProtKB/TrEMBL
    F7BGR7
    Related
    ENSMUSP00000128810.3, ENSMUST00000172000.3
    Conserved Domains (6) summary
    smart00343
    Location:277 → 292
    ZnF_C2HC; zinc finger
    cd12606
    Location:118 → 184
    RRM1_RBM4; RNA recognition motif 1 in vertebrate RNA-binding protein 4 (RBM4)
    cd12607
    Location:194 → 260
    RRM2_RBM4; RNA recognition motif 2 in vertebrate RNA-binding protein 4 (RBM4)
    cd12608
    Location:1 → 71
    RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    TIGR01661
    Location:14 → 265
    ELAV_HUD_SF; ELAV/HuD family splicing factor
    cl17169
    Location:79 → 184
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001290128.1 → NP_001277057.1  Rbm14-Rbm4 readthrough isoform b

    See identical proteins and their annotated locations for NP_001277057.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC141437, AC147618, EU287940
    UniProtKB/TrEMBL
    B0LM42
    Related
    ENSMUSP00000136623.2, ENSMUST00000179909.8
    Conserved Domains (3) summary
    smart00343
    Location:136 → 151
    ZnF_C2HC; zinc finger
    cd12608
    Location:1 → 71
    RRM1_CoAA; RNA recognition motif 1 in vertebrate RRM-containing coactivator activator/modulator (CoAA)
    cl17169
    Location:79 → 113
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. NR_157185.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC141437, AC147618
    Related
    ENSMUST00000178353.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4792941..4861662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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