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RGS19 regulator of G protein signaling 19 [ Homo sapiens (human) ]

Gene ID: 10287, updated on 3-Apr-2024

Summary

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Official Symbol
RGS19provided by HGNC
Official Full Name
regulator of G protein signaling 19provided by HGNC
Primary source
HGNC:HGNC:13735
See related
Ensembl:ENSG00000171700 MIM:605071; AllianceGenome:HGNC:13735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAIP; RGSGAIP
Summary
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 10.5), bone marrow (RPKM 8.6) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
20q13.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (64073181..64079964, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (65893259..65900019, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62704534..62711317, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13204 Neighboring gene SOX18 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62684293-62684982 Neighboring gene SRY-box transcription factor 18 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62686363-62687052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62687053-62687742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62688433-62689122 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:62689123-62689810 Neighboring gene transcription elongation factor A2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18263 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13205 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13207 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:62711846-62712019 Neighboring gene microRNA 6813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13209 Neighboring gene opioid related nociceptin receptor 1 Neighboring gene LKAAEAR motif containing 1 Neighboring gene MPRA-validated peak4324 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723260-62723993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62723994-62724726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62732783-62733284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:62738466-62738966 Neighboring gene neuropeptides B and W receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer. Liu Y, et al. Bioengineered, 2021 Dec. PMID 34482807, Free PMC Article
  2. RGS19 converts iron deprivation stress into a growth-inhibitory signal. Hwang J, et al. Biochem Biophys Res Commun, 2015 Aug 14. PMID 26116529
  3. 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19. Wang Q, et al. Cell Signal, 2014 Sep. PMID 24793302, Free PMC Article
  4. Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum. Ip AK, et al. Mol Cell Biochem, 2012 Mar. PMID 22045062
  5. RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling. Tso PH, et al. Cancer Lett, 2011 Oct 28. PMID 21705135

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
    Title: Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer.
  2. RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal.
    Title: RGS19 converts iron deprivation stress into a growth-inhibitory signal.
  3. RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect.
    Title: 5-HT1A receptor-mediated phosphorylation of extracellular signal-regulated kinases (ERK1/2) is modulated by regulator of G protein signaling protein 19.
  4. Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity.
    Title: Profiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.
  5. The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23.
    Title: RGS19 inhibits Ras signaling through Nm23H1/2-mediated phosphorylation of the kinase suppressor of Ras.
  6. elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases
    Title: Elevated expression of RGS19 impairs the responsiveness of stress-activated protein kinases to serum.
  7. cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced
    Title: RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association study of 182 candidate genes in anorexia nervosa.
  9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
  10. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling
    Title: GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in brush border IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 19
Names
G alpha interacting protein
G protein signalling regulator 19
guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein
regulator of G-protein signalling 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039467.2 → NP_001034556.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_001034556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    BC001318, BM554550
    Consensus CDS
    CCDS13555.1
    UniProtKB/Swiss-Prot
    A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
    UniProtKB/TrEMBL
    Q6I9S5
    Related
    ENSP00000333194.5, ENST00000332298.9
    Conserved Domains (1) summary
    cd08745
    Location:87 → 204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

  2. NM_005873.3 → NP_005864.1  regulator of G-protein signaling 19

    See identical proteins and their annotated locations for NP_005864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AF285097, AL590548, BC063010
    Consensus CDS
    CCDS13555.1
    UniProtKB/Swiss-Prot
    A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
    UniProtKB/TrEMBL
    Q6I9S5
    Related
    ENSP00000378483.1, ENST00000395042.2
    Conserved Domains (1) summary
    cd08745
    Location:87 → 204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    64073181..64079964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260183.3 → XP_005260240.1  regulator of G-protein signaling 19 isoform X3

    See identical proteins and their annotated locations for XP_005260240.1

    UniProtKB/TrEMBL
    B4DP94, Q6I9S5
    Conserved Domains (1) summary
    cd08745
    Location:65 → 182
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

  2. XM_047439824.1 → XP_047295780.1  regulator of G-protein signaling 19 isoform X2

    UniProtKB/Swiss-Prot
    A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

  3. XM_005260182.4 → XP_005260239.1  regulator of G-protein signaling 19 isoform X3

    See identical proteins and their annotated locations for XP_005260239.1

    UniProtKB/TrEMBL
    B4DP94, Q6I9S5
    Conserved Domains (1) summary
    cd08745
    Location:65 → 182
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

  4. XM_011528485.3 → XP_011526787.1  regulator of G-protein signaling 19 isoform X2

    See identical proteins and their annotated locations for XP_011526787.1

    UniProtKB/Swiss-Prot
    A8K216, E1P5G9, P49795, Q53XN0, Q8TD60
    UniProtKB/TrEMBL
    Q6I9S5
    Conserved Domains (1) summary
    cd08745
    Location:87 → 204
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

  5. XM_011528484.3 → XP_011526786.1  regulator of G-protein signaling 19 isoform X1

    UniProtKB/TrEMBL
    Q6I9S5
    Conserved Domains (1) summary
    cd08745
    Location:116 → 233
    RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    65893259..65900019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322828.1 → XP_054178803.1  regulator of G-protein signaling 19 isoform X3

    UniProtKB/TrEMBL
    B4DP94

  2. XM_054322827.1 → XP_054178802.1  regulator of G-protein signaling 19 isoform X2

    UniProtKB/Swiss-Prot
    A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

  3. XM_054322826.1 → XP_054178801.1  regulator of G-protein signaling 19 isoform X2

    UniProtKB/Swiss-Prot
    A8K216, E1P5G9, P49795, Q53XN0, Q8TD60

  4. XM_054322829.1 → XP_054178804.1  regulator of G-protein signaling 19 isoform X3

    UniProtKB/TrEMBL
    B4DP94

  5. XM_054322825.1 → XP_054178800.1  regulator of G-protein signaling 19 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49795.1 GenPept UniProtKB/Swiss-Prot:P49795

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