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LOC102724594 U2 small nuclear RNA auxiliary factor 1 like 5 [ Homo sapiens (human) ]

Gene ID: 102724594, updated on 3-Mar-2024

Summary

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Gene symbol
LOC102724594
Gene description
U2 small nuclear RNA auxiliary factor 1 like 5
See related
Ensembl:ENSG00000275895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U2AF1L5
Annotation information
Note: GeneID:102724594 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:7307. [11 Jun 2021]
Expression
Ubiquitous expression in bone marrow (RPKM 57.2), colon (RPKM 39.0) and 25 other tissues See more
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Genomic context

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Location:
21p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (6484623..6499248, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724701 Neighboring gene uncharacterized CH507-145C22.1 Neighboring gene cystathionine beta-synthase like Neighboring gene crystallin alpha A2 Neighboring gene 39S ribosomal protein L51, mitochondrial-like Neighboring gene FOXM1-regulated, gastric cancer associated-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000021.9 Chromosome 21 Reference GRCh38.p14 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response. Cámara-Quílez M, et al. Cancers (Basel), 2020 Aug 27. PMID 32867128, Free PMC Article
  2. MICALL2 as a substrate of ubiquitinase TRIM21 regulates tumorigenesis of colorectal cancer. Wen P, et al. Cell Commun Signal, 2022 Oct 28. PMID 36307841, Free PMC Article
  3. KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II. McNamara RP, et al. Mol Cell, 2016 Jan 7. PMID 26725010, Free PMC Article
  4. RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. Guderian G, et al. J Biol Chem, 2011 Jan 21. PMID 21081503, Free PMC Article
  5. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
splicing factor U2AF 35 kDa subunit-like protein
Names
U2 small nuclear RNA auxiliary factor 1-like protein 5
splicing factor U2AF 35 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320646.2 → NP_001307575.1  splicing factor U2AF 35 kDa subunit-like protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI334628, AL522322, DA211043
    UniProtKB/Swiss-Prot
    Q01081, Q701P4, Q71RF1
    UniProtKB/TrEMBL
    B5BU08
    Related
    ENST00000610664.5
    Conserved Domains (2) summary
    pfam00642
    Location:149 → 175
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd12538
    Location:43 → 146
    RRM_U2AF35; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)

  2. NM_001320648.2 → NP_001307577.1  splicing factor U2AF 35 kDa subunit-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is the same length but differs in the N-terminal region compared to isoform 1.
    Source sequence(s)
    AI334628, CN280269, DA211043
    UniProtKB/TrEMBL
    B5BU08
    Conserved Domains (2) summary
    pfam00642
    Location:149 → 175
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cd12538
    Location:43 → 146
    RRM_U2AF35; RNA recognition motif (RRM) found in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)

  3. NM_001320650.2 → NP_001307579.1  splicing factor U2AF 35 kDa subunit-like protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. It encodes isoform 3, which has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AI334628, BG612658, DA211043
    Conserved Domains (2) summary
    cd12538
    Location:29 → 108
    RRM_U2AF35; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)
    pfam00642
    Location:111 → 137
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

  4. NM_001320651.2 → NP_001307580.1  splicing factor U2AF 35 kDa subunit-like protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 4, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI334628, CN280267, DA211043
    UniProtKB/Swiss-Prot
    Q01081
    Conserved Domains (2) summary
    pfam00642
    Location:76 → 102
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:1 → 73
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    6484623..6499248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028219.2 → XP_016883708.1  splicing factor U2AF 35 kDa subunit-like protein isoform X1

    Conserved Domains (2) summary
    pfam00642
    Location:116 → 142
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:43 → 113
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_017028220.2 → XP_016883709.1  splicing factor U2AF 35 kDa subunit-like protein isoform X2

  3. XM_024452037.2 → XP_024307805.1  splicing factor U2AF 35 kDa subunit-like protein isoform X3

    Conserved Domains (2) summary
    pfam00642
    Location:76 → 102
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:1 → 73
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_024452039.2 → XP_024307807.1  splicing factor U2AF 35 kDa subunit-like protein isoform X3

    Conserved Domains (2) summary
    pfam00642
    Location:76 → 102
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:1 → 73
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_024452038.2 → XP_024307806.1  splicing factor U2AF 35 kDa subunit-like protein isoform X3

    Conserved Domains (2) summary
    pfam00642
    Location:76 → 102
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    cl17169
    Location:1 → 73
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version

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