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CT45A8 cancer/testis antigen family 45 member A8 [ Homo sapiens (human) ]

Gene ID: 102723737, updated on 10-Oct-2023

Summary

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Official Symbol
CT45A8provided by HGNC
Official Full Name
cancer/testis antigen family 45 member A8provided by HGNC
Primary source
HGNC:HGNC:51261
See related
Ensembl:ENSG00000278085 AllianceGenome:HGNC:51261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT45-2; CT45A2; CT45A9
Summary
Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 8.0) See more
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Genomic context

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See CT45A8 in Genome Data Viewer
Location:
Xq26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135846497..135854592, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134154884..134162973, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134928695..134936735, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A2 Neighboring gene cancer/testis antigen family 45 member A7 Neighboring gene cancer/testis antigen family 45 member A9 Neighboring gene cancer/testis antigen family 45 member A10 Neighboring gene Sharpr-MPRA regulatory region 13624

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
cancer/testis antigen family 45 member A8
Names
Cancer/testis antigen 45-2
Cancer/testis antigen 45A2
Cancer/testis antigen 45A9
Cancer/testis antigen family 45 member A2
Cancer/testis antigen family 45 member A9
cancer/testis antigen 45A8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291535.1 → NP_001278464.1  cancer/testis antigen family 45 member A8

    See identical proteins and their annotated locations for NP_001278464.1

    Status: VALIDATED

    Source sequence(s)
    AC240441
    Consensus CDS
    CCDS76033.1
    UniProtKB/Swiss-Prot
    P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
    Related
    ENSP00000481184.1, ENST00000611660.5
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    135846497..135854592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531241.3 → XP_011529543.1  cancer/testis antigen family 45 member A8 isoform X1

    See identical proteins and their annotated locations for XP_011529543.1

    UniProtKB/Swiss-Prot
    P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
    Related
    ENSP00000480644.1, ENST00000611438.1
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

  2. XM_006724799.2 → XP_006724862.1  cancer/testis antigen family 45 member A8 isoform X1

    See identical proteins and their annotated locations for XP_006724862.1

    UniProtKB/Swiss-Prot
    P0DMV1, P0DMV2, Q5DJT8, Q5JRH3
    Conserved Domains (1) summary
    pfam15300
    Location:122 → 183
    INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    134154884..134162973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326361.1 → XP_054182336.1  cancer/testis antigen family 45 member A8 isoform X1

  2. XM_054326362.1 → XP_054182337.1  cancer/testis antigen family 45 member A8 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DMV1.1 GenPept UniProtKB/Swiss-Prot:P0DMV1

Gene LinkOut

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