Hand2os1 Hand2, opposite strand 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hand2os1provided by MGI
Official Full Name: Hand2, opposite strand 1provided by MGI
Primary source: MGI:MGI:5578769
See related: Ensembl:ENSMUSG00000100510 AllianceGenome:MGI:5578769
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Uph; Gm28063; Hand2-as1
Summary: Involved in positive regulation of gene expression. Acts upstream of or within with a positive effect on cardiac right ventricle morphogenesis. Acts upstream of or within transcription elongation from RNA polymerase II promoter. Located in chromatin; cytoplasm; and nucleoplasm. Is expressed in several structures, including alimentary system; heart; limb bud; liver; and spleen. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 14.7), bladder adult (RPKM 12.0) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 B2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (57757296..57773894, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (57304261..57320859, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Hand2os1 locus dampens HAND2 expression to restrain cardiomyocyte proliferation, thereby orchestrating a balanced development of cardiac cell lineages.
Title: The lncRNA Hand2os1/Uph locus orchestrates heart development through regulation of precise expression of Hand2.
transcription of a Hand2-associated long non-coding RNA, which we named upperhand (Uph), is required to maintain the super-enhancer signature and elongation of RNA polymerase II through the Hand2 enhancer locus
Title: Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect cardiac right ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.