Hoxb3os homeobox B3 and homeobox B2, opposite strand [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hoxb3osprovided by MGI
Official Full Name: homeobox B3 and homeobox B2, opposite strandprovided by MGI
Primary source: MGI:MGI:103211
See related: AllianceGenome:MGI:103211
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hoxb3s; Gm11530
Summary: Acts upstream of or within TORC1 signaling; protein phosphorylation; and respiratory electron transport chain. Is expressed in several structures, including branchial arch; intestine; liver; lung; and rhombomere. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E14 (RPKM 4.0), CNS E11.5 (RPKM 3.6) and 25 other tissues See more
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Genomic context

Location:: 11 59.85 cM; 11 D

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96233860..96244220, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96343034..96353394, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.
Title: Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease.
These findings identify Hoxb3os as a novel lncRNA that is down-regulated in Autosomal dominant polycystic kidney disease and regulates mTOR signaling and mitochondrial respiration.
Title: Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Other Names

homeo box B3, opposite strand transcript
homeobox B3, opposite strand transcript

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory electron transport chain	IMP Inferred from Mutant Phenotype more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.