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Cmtm7 CKLF-like MARVEL transmembrane domain containing 7 [ Mus musculus (house mouse) ]

Gene ID: 102545, updated on 21-Apr-2024

Summary

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Official Symbol
Cmtm7provided by MGI
Official Full Name
CKLF-like MARVEL transmembrane domain containing 7provided by MGI
Primary source
MGI:MGI:2447166
See related
Ensembl:ENSMUSG00000032436 AllianceGenome:MGI:2447166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LNV; Cklfsf7
Summary
Predicted to enable cytokine activity. Acts upstream of or within B-1a B cell differentiation. Predicted to be located in extracellular space and membrane. Predicted to be integral component of membrane. Is expressed in thymus primordium. Orthologous to human CMTM7 (CKLF like MARVEL transmembrane domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 190.5), stomach adult (RPKM 118.3) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F3; 9 65.13 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114585904..114611061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114756836..114781993, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 light intermediate chain 1 Neighboring gene STARR-seq mESC enhancer starr_25388 Neighboring gene STARR-positive B cell enhancer ABC_E2310 Neighboring gene CKLF-like MARVEL transmembrane domain containing 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114662028-114662553 Neighboring gene STARR-seq mESC enhancer starr_25390 Neighboring gene STARR-seq mESC enhancer starr_25391 Neighboring gene CKLF-like MARVEL transmembrane domain containing 8 Neighboring gene predicted gene, 23889 Neighboring gene predicted gene, 30448

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells. Liu Z, et al. Cell Immunol, 2020 Jun. PMID 32305130
  2. Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage. Liu Z, et al. Int Immunol, 2019 Oct 16. PMID 31081901
  3. CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells. Liu Z, et al. Eur J Immunol, 2020 Jun. PMID 32022930
  4. A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells. Zhang Y, et al. Int Immunol, 2014 Jan. PMID 24080084
  5. Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor. Miyazaki A, et al. PLoS One, 2012. PMID 22363743, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igmu repertoire of splenic B-1a cells.
    Title: Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.
  2. CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
    Title: CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells.
  3. The Cmtm7 deficiency resulted in a slow proliferation and high cell death rate of TrB-1a cells. Thus, Cmtm7 controls B-1a cell development at the transitional stage.
    Title: Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage.
  4. The reduction of B-1a cells in Cmtm7(flox/) mice was associated with reduced BCR expression.
    Title: A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.
  5. CMTM7 functions to link sIgM and BLNK in the plasma membrane.
    Title: Identification of CMTM7 as a transmembrane linker of BLNK and the B-cell receptor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B-1a B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CKLF-like MARVEL transmembrane domain-containing protein 7
Names
chemokine-like factor super family 7
chemokine-like factor superfamily member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252479.1 → NP_001239408.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001239408.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AA002761, AC163344, BC038633
    Consensus CDS
    CCDS57709.1
    UniProtKB/TrEMBL
    Q3THH0
    Related
    ENSMUSP00000081927.8, ENSMUST00000084867.9
    Conserved Domains (1) summary
    cl04571
    Location:32 → 119
    MARVEL; Membrane-associating domain

  2. NM_133978.2 → NP_598739.1  CKLF-like MARVEL transmembrane domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_598739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC163344, AF188504
    Consensus CDS
    CCDS57710.1
    UniProtKB/Swiss-Prot
    Q8CHW2, Q9ESD6
    UniProtKB/TrEMBL
    Q3THH0
    Related
    ENSMUSP00000035009.9, ENSMUST00000035009.16
    Conserved Domains (1) summary
    pfam01284
    Location:32 → 152
    MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    114585904..114611061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESD6.1 GenPept UniProtKB/Swiss-Prot:Q9ESD6

Gene LinkOut

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