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MIR8066 microRNA 8066 [ Homo sapiens (human) ]

Gene ID: 102465868, updated on 10-Oct-2023

Summary

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Official Symbol
MIR8066provided by HGNC
Official Full Name
microRNA 8066provided by HGNC
Primary source
HGNC:HGNC:50043
See related
Ensembl:ENSG00000273882 miRBase:MI0025902; AllianceGenome:HGNC:50043
Gene type
ncRNA
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hsa-mir-8066
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

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Location:
4q24
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (101240795..101240872, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (104555558..104555635, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (102161952..102162029, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21745 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:101731907-101732751 Neighboring gene long intergenic non-protein coding RNA 1217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21746 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71492 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71505 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:101887592-101888092 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:101907345-101907846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21747 Neighboring gene Sharpr-MPRA regulatory region 8198 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:101961837-101962456 Neighboring gene protein phosphatase 3 catalytic subunit alpha Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:102035867-102036688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21748 Neighboring gene NANOG hESC enhancer GRCh37_chr4:102076410-102076911 Neighboring gene Sharpr-MPRA regulatory region 422 Neighboring gene Sharpr-MPRA regulatory region 14793 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:102225920-102226503 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15591 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15592 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15593 Neighboring gene microRNA 1255a Neighboring gene uncharacterized LOC90024

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization and Identification of novel serum microRNAs in sepsis patients with different outcomes. Wang HJ, et al. Shock, 2013 Jun. PMID 23612084
  2. miRBase: microRNA sequences, targets and gene nomenclature. Griffiths-Jones S, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381832, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • microRNA mir-8066

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_107033.1 RNA Sequence

    Status: PROVISIONAL

    Source sequence(s)
    AP001939
    Related
    ENST00000617280.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    101240795..101240872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    104555558..104555635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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