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Lars2 leucyl-tRNA synthetase, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 102436, updated on 5-Mar-2024

Summary

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Official Symbol
Lars2provided by MGI
Official Full Name
leucyl-tRNA synthetase, mitochondrialprovided by MGI
Primary source
MGI:MGI:2142973
See related
Ensembl:ENSMUSG00000035202 AllianceGenome:MGI:2142973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LEURS; Kiaa0028
Summary
Predicted to enable leucine-tRNA ligase activity. Predicted to be involved in leucyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in pancreas epithelium. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 1105.1), placenta adult (RPKM 827.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Lars2 in Genome Data Viewer
Location:
9 F4; 9 73.92 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123196001..123291731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123366927..123462675)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 158 Neighboring gene STARR-seq mESC enhancer starr_25561 Neighboring gene STARR-seq mESC enhancer starr_25562 Neighboring gene sterol carrier protein 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_25564 Neighboring gene STARR-seq mESC enhancer starr_25565 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123275808-123276108 Neighboring gene predicted gene, 46137 Neighboring gene STARR-seq mESC enhancer starr_25567 Neighboring gene predicted gene, 40586 Neighboring gene LIM domains containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5115 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:123428421-123428574

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel noncoding RNA rescues mutant SOD1-mediated cell death. Chang Y, et al. FASEB J, 2008 Mar. PMID 17957031
  2. Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. Wang Z, et al. Immunity, 2022 Jun 14. PMID 35659337
  3. Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Patel SD, et al. Front Cell Dev Biol, 2022. PMID 36092713, Free PMC Article
  4. Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3. Kiss H, et al. Mamm Genome, 2002 Nov. PMID 12461651
  5. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Jung H, et al. Nat Neurosci, 2018 Sep. PMID 30104731

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion.
    Title: Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables leucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leucine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leucyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable leucine--tRNA ligase, mitochondrial
NP_001335096.1
NP_001335097.1
NP_694808.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348167.2 → NP_001335096.1  probable leucine--tRNA ligase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125254, AC164123
    Consensus CDS
    CCDS23659.1
    UniProtKB/Swiss-Prot
    A6H6S4, Q8VDC0
    UniProtKB/TrEMBL
    Q14DP3, Q14DS6
    Conserved Domains (1) summary
    cl26128
    Location:56 → 900
    tRNA-synt_1g; tRNA synthetases class I (M)

  2. NM_001348168.2 → NP_001335097.1  probable leucine--tRNA ligase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125254, AC164123
    UniProtKB/Swiss-Prot
    Q8VDC0
    Conserved Domains (1) summary
    cl26128
    Location:5 → 652
    tRNA-synt_1g; tRNA synthetases class I (M)

  3. NM_153168.4 → NP_694808.1  probable leucine--tRNA ligase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_694808.1

    Status: VALIDATED

    Source sequence(s)
    AC125254, AC164123
    Consensus CDS
    CCDS23659.1
    UniProtKB/Swiss-Prot
    A6H6S4, Q8VDC0
    UniProtKB/TrEMBL
    Q14DP3, Q14DS6
    Related
    ENSMUSP00000036710.8, ENSMUST00000038863.9
    Conserved Domains (1) summary
    cl26128
    Location:56 → 900
    tRNA-synt_1g; tRNA synthetases class I (M)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    123196001..123291731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDC0.1 GenPept UniProtKB/Swiss-Prot:Q8VDC0

Gene LinkOut

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