U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hinfp histone H4 transcription factor [ Mus musculus (house mouse) ]

Gene ID: 102423, updated on 9-May-2024

Summary

Go to the top of the page Help
Official Symbol
Hinfpprovided by MGI
Official Full Name
histone H4 transcription factorprovided by MGI
Primary source
MGI:MGI:2429620
See related
Ensembl:ENSMUSG00000032119 AllianceGenome:MGI:2429620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mizf; HiNF-P
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in in utero embryonic development; regulation of gene expression; and transcription, DNA-templated. Predicted to be located in Cajal body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human HINFP (histone H4 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.6), CNS E14 (RPKM 5.0) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A5.2; 9 24.84 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44201509..44217003, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44292438..44305716, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NLR family member X1 Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44113766-44114058 Neighboring gene C2 calcium-dependent domain containing 2-like Neighboring gene STARR-seq mESC enhancer starr_23963 Neighboring gene dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 Neighboring gene H2A.X variant histone

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency. Ghule PN, et al. Cell Cycle, 2015 Aug 3. PMID 26030398, Free PMC Article
  2. Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition. Xie RL, et al. Gene, 2007 Nov 1. PMID 17826007, Free PMC Article
  3. Fidelity of histone gene regulation is obligatory for genome replication and stability. Ghule PN, et al. Mol Cell Biol, 2014 Jul. PMID 24797072, Free PMC Article
  4. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. Sekimata M, et al. Nucleic Acids Res, 2004. PMID 14752047, Free PMC Article
  5. The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles. Xie R, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19590016, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Induction of Hinfp begins at the 4-cell stage. Maternally encoded Hinfp sustains development of pre-implantation stage embryos. Hinfp loss delays growth of blastocyst stage embryos that later fail to implant. Hinfp ablation severely reduces histone H4 mRNA and causes DNA damage. Transmission of maternal Hinfp transcripts and zygotic activation of the Hinfp gene together are neeeded to control early H4 gene expression.
    Title: Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos.
  2. simultaneous loss of both Hinfp and the p53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation.
    Title: p53 checkpoint ablation exacerbates the phenotype of Hinfp dependent histone H4 deficiency.
  3. Data show that conditional ablation of HINFP compromises cell proliferation, impairs DNA synthesis, alters nucleosome spacing and increases double-stranded DNA damage.
    Title: Fidelity of histone gene regulation is obligatory for genome replication and stability.
  4. The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development.
    Title: Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.
  5. Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
    Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
  6. The dependence of HiNF-P gene transcription on cyclin E/CDK2/p220NPAT signaling defines a novel feed-forward loop that may sustain HiNF-P expression in proliferating cells to support the cell cycle regulated synthesis of histone H4 proteins.
    Title: Transcriptional activation of the histone nuclear factor P (HiNF-P) gene by HiNF-P and its cyclin E/CDK2 responsive co-factor p220NPAT defines a novel autoregulatory loop at the G1/S phase transition.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp434F162

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histone H4 transcription factor
Names
MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
MBD2-interacting zinc finger protein
histone nuclear factor P
methyl-CpG-binding protein 2-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001405064.1 → NP_001391993.1  histone H4 transcription factor

    Status: VALIDATED

    Source sequence(s)
    AC124577
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9

  2. NM_001405065.1 → NP_001391994.1  histone H4 transcription factor

    Status: VALIDATED

    Source sequence(s)
    AC124577
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    Related
    ENSMUSP00000034629.6, ENSMUST00000034629.6

  3. NM_001405066.1 → NP_001391995.1  histone H4 transcription factor

    Status: VALIDATED

    Source sequence(s)
    AC124577
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9

  4. NM_172162.4 → NP_751894.2  histone H4 transcription factor

    See identical proteins and their annotated locations for NP_751894.2

    Status: VALIDATED

    Source sequence(s)
    AC124577
    Consensus CDS
    CCDS23102.1
    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
    Related
    ENSMUSP00000149879.2, ENSMUST00000216508.2
    Conserved Domains (2) summary
    COG5048
    Location:224 → 377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:282 → 302
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44201509..44217003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242379.3 → XP_011240681.1  histone H4 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011240681.1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233 → 386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_011242378.4 → XP_011240680.1  histone H4 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011240680.1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233 → 386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_006509897.5 → XP_006509960.1  histone H4 transcription factor isoform X3

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:231 → 384
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289 → 309
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_030243934.2 → XP_030099794.1  histone H4 transcription factor isoform X2

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233 → 386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_011242376.4 → XP_011240678.1  histone H4 transcription factor isoform X1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:240 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298 → 318
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036154502.1 → XP_036010395.1  histone H4 transcription factor isoform X2

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233 → 386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030243935.2 → XP_030099795.1  histone H4 transcription factor isoform X4

    UniProtKB/Swiss-Prot
    E9QPQ4, Q8BWY0, Q8K1K9
    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:224 → 377
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:282 → 302
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_030243933.2 → XP_030099793.1  histone H4 transcription factor isoform X2

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233 → 386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_011242377.4 → XP_011240679.1  histone H4 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_011240679.1

    UniProtKB/TrEMBL
    Q4FK13
    Conserved Domains (2) summary
    COG5048
    Location:233 → 386
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1K9.3 GenPept UniProtKB/Swiss-Prot:Q8K1K9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous