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Cog4 component of oligomeric golgi complex 4 [ Mus musculus (house mouse) ]

Gene ID: 102339, updated on 11-Apr-2024

Summary

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Official Symbol
Cog4provided by MGI
Official Full Name
component of oligomeric golgi complex 4provided by MGI
Primary source
MGI:MGI:2142808
See related
Ensembl:ENSMUSG00000031753 AllianceGenome:MGI:2142808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D8Ertd515e
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in Golgi organization; Golgi vesicle prefusion complex stabilization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport. Predicted to be located in Golgi apparatus and membrane. Predicted to be part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 20.1), testis adult (RPKM 19.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.76 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111573232..111608866)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110846600..110882234)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene predicted gene, 22193 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene fucose kinase Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 26132

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, vesicle recycling within Golgi ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Golgi transport complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
conserved oligomeric Golgi complex subunit 4
Names
COG complex subunit 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310607.1 → NP_001297536.1  conserved oligomeric Golgi complex subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_001297536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AY223866, BM226598
    Consensus CDS
    CCDS80931.1
    UniProtKB/TrEMBL
    G3UWH9, Q7TSQ9
    Related
    ENSMUSP00000128518.2, ENSMUST00000165867.8
    Conserved Domains (2) summary
    pfam04437
    Location:513 → 699
    RINT1_TIP1; RINT-1 / TIP-1 family
    pfam08318
    Location:115 → 424
    COG4; COG4 transport protein

  2. NM_133973.2 → NP_598734.1  conserved oligomeric Golgi complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_598734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer isoform (1).
    Source sequence(s)
    AY223866, BM226598, CN843612
    Consensus CDS
    CCDS40477.1
    UniProtKB/Swiss-Prot
    Q3T9K1, Q8R1U1
    UniProtKB/TrEMBL
    G3UWH9
    Related
    ENSMUSP00000034203.10, ENSMUST00000034203.17
    Conserved Domains (2) summary
    pfam04437
    Location:586 → 772
    RINT1_TIP1; RINT-1 / TIP-1 family
    pfam08318
    Location:188 → 497
    COG4; COG4 transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111573232..111608866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_387727.3 RNA Sequence

  2. XR_003947213.1 RNA Sequence

  3. XR_004934744.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1U1.1 GenPept UniProtKB/Swiss-Prot:Q8R1U1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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