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ANGPTL7 angiopoietin like 7 [ Homo sapiens (human) ]

Gene ID: 10218, updated on 23-Mar-2024

Summary

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Official Symbol
ANGPTL7provided by HGNC
Official Full Name
angiopoietin like 7provided by HGNC
Primary source
HGNC:HGNC:24078
See related
Ensembl:ENSG00000171819 MIM:618517; AllianceGenome:HGNC:24078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AngX; CDT6; dJ647M16.1
Summary
Enables identical protein binding activity. Involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 2.5), gall bladder (RPKM 2.2) and 15 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.22
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11189355..11195981)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10730945..10737571)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11249412..11256038)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mechanistic target of rapamycin kinase Neighboring gene RNA, U6 small nuclear 537, pseudogene Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr1:11237905-11238443 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11249765-11250265 Neighboring gene MPRA-validated peak73 silencer Neighboring gene RNA, U6 small nuclear 291, pseudogene Neighboring gene ribosomal protein L39 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity. Leentjens M, et al. Front Endocrinol (Lausanne), 2022. PMID 36017324, Free PMC Article
  2. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants. Xia X, et al. Biomed Res Int, 2020. PMID 33313310, Free PMC Article
  3. Angiopoietin-like protein 7 mediates TNF-α-induced adhesion and oxidative stress in human umbilical vein epithelial cell. Li J, et al. Gen Physiol Biophys, 2020 May. PMID 32525822
  4. Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma. Tanigawa Y, et al. PLoS Genet, 2020 May. PMID 32369491, Free PMC Article
  5. Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure. Zhang C, et al. Cardiorenal Med, 2020. PMID 31962333

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANGPTL7 and Its Role in IOP and Glaucoma.
    Title: ANGPTL7 and Its Role in IOP and Glaucoma.
  2. The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
    Title: The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
  3. Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.
    Title: Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.
  4. Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.
    Title: Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.
  5. ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.
    Title: ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.
  6. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity.
    Title: Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity.
  7. Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure.
    Title: Angiopoietin-Like Protein 7 and Short-Term Mortality in Acute Heart Failure.
  8. Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants.
    Title: Cord Blood Levels of Angiopoietin-Like 7 (ANGPTL7) in Preterm Infants.
  9. Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
    Title: Angptl7 promotes insulin resistance and type 2 diabetes mellitus by multiple mechanisms including SOCS3-mediated IRS1 degradation.
  10. Angiopoietin-like protein 7 mediates TNF-alpha-induced adhesion and oxidative stress in human umbilical vein epithelial cell.
    Title: Angiopoietin-like protein 7 mediates TNF-α-induced adhesion and oxidative stress in human umbilical vein epithelial cell.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of vasculature development involved in avascular cornea development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiopoietin-related protein 7
Names
angiopoietin-like factor (CDT6)
angiopoietin-like protein 7
cornea-derived transcript 6 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021146.4 → NP_066969.1  angiopoietin-related protein 7 precursor

    See identical proteins and their annotated locations for NP_066969.1

    Status: VALIDATED

    Source sequence(s)
    BC001881
    Consensus CDS
    CCDS128.1
    UniProtKB/Swiss-Prot
    B2R9B2, F1T0A6, O43827, Q4ZGK4
    Related
    ENSP00000366015.3, ENST00000376819.4
    Conserved Domains (2) summary
    cd00087
    Location:129 → 341
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl25732
    Location:37 → 109
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    11189355..11195981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424430.1 → XP_047280386.1  angiopoietin-related protein 7 isoform X2

  2. XM_017000004.2 → XP_016855493.1  angiopoietin-related protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    10730945..10737571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333755.1 → XP_054189730.1  angiopoietin-related protein 7 isoform X2

  2. XM_054333754.1 → XP_054189729.1  angiopoietin-related protein 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43827.1 GenPept UniProtKB/Swiss-Prot:O43827

Gene LinkOut

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