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Taf5l TATA-box binding protein associated factor 5 like [ Mus musculus (house mouse) ]

Gene ID: 102162, updated on 5-Mar-2024

Summary

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Official Symbol
Taf5lprovided by MGI
Official Full Name
TATA-box binding protein associated factor 5 likeprovided by MGI
Primary source
MGI:MGI:1919039
See related
Ensembl:ENSMUSG00000038697 AllianceGenome:MGI:1919039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110005N04Rik
Summary
Predicted to enable transcription coactivator activity. Involved in regulation of somatic stem cell population maintenance and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in genitourinary system and tail. Orthologous to human TAF5L (TATA-box binding protein associated factor 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 30.0), ovary adult (RPKM 20.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E2; 8 72.31 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (124723049..124748136, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (123996310..124021397, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29773 Neighboring gene nucleoporin 133 Neighboring gene ATP-binding cassette, sub-family B member 10 Neighboring gene predicted gene, 53469 Neighboring gene STARR-seq mESC enhancer starr_22990 Neighboring gene STARR-seq mESC enhancer starr_22991 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 1967 Neighboring gene URB2 ribosome biogenesis 2 homolog (S. cerevisiae) Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:126581223-126581424 Neighboring gene predicted gene, 29897

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, et al. Mol Cell, 2019 Jun 20. PMID 31005419, Free PMC Article
  2. Distinct GCN5/PCAF-containing complexes function as co-activators and are involved in transcription factor and global histone acetylation. Nagy Z, et al. Oncogene, 2007 Aug 13. PMID 17694077
  3. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. Schiltz RL, et al. J Biol Chem, 1999 Jan 15. PMID 9880483
  4. Histone-like TAFs within the PCAF histone acetylase complex. Ogryzko VV, et al. Cell, 1998 Jul 10. PMID 9674425
  5. UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. Brand M, et al. EMBO J, 2001 Jun 15. PMID 11406595, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF5L and TAF6L maintain self-renewal of embryonic stem cells via the MYC regulatory network.
    Title: TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of somatic stem cell population maintenance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
NOT part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Names
PAF65-beta
PCAF-associated factor 65 beta
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357315.1 → NP_001344244.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

    Status: VALIDATED

    Source sequence(s)
    AC139575, AI849020, AK033477
    Consensus CDS
    CCDS22767.1
    UniProtKB/Swiss-Prot
    Q8BTL5, Q91WQ5
    Related
    ENSMUSP00000090726.6, ENSMUST00000093039.6
    Conserved Domains (3) summary
    cd08044
    Location:67 → 201
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    cd00200
    Location:276 → 581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:345 → 381
    7WD40; WD40 repeat [structural motif]

  2. NM_133966.3 → NP_598727.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

    See identical proteins and their annotated locations for NP_598727.1

    Status: VALIDATED

    Source sequence(s)
    AI849020, AK033477, AK089463, BB852568
    Consensus CDS
    CCDS22767.1
    UniProtKB/Swiss-Prot
    Q8BTL5, Q91WQ5
    Related
    ENSMUSP00000128710.2, ENSMUST00000165628.9
    Conserved Domains (3) summary
    cd08044
    Location:67 → 201
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    cd00200
    Location:276 → 581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:345 → 381
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    124723049..124748136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WQ5.1 GenPept UniProtKB/Swiss-Prot:Q91WQ5

Gene LinkOut

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