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Snx25 sorting nexin 25 [ Mus musculus (house mouse) ]

Gene ID: 102141, updated on 11-Apr-2024

Summary

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Official Symbol
Snx25provided by MGI
Official Full Name
sorting nexin 25provided by MGI
Primary source
MGI:MGI:2142610
See related
Ensembl:ENSMUSG00000038291 AllianceGenome:MGI:2142610
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm173; Gm1699; Sbbi31
Summary
Enables type I transforming growth factor beta receptor binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway and receptor catabolic process. Located in endosome. Orthologous to human SNX25 (sorting nexin 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.5), lung adult (RPKM 7.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snx25 in Genome Data Viewer
Location:
8 B1.1; 8 26.03 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (46486298..46605535, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (46033261..46152441, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene UFM1-specific peptidase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10496 Neighboring gene ankyrin repeat domain 37 Neighboring gene Lrp2 binding protein Neighboring gene STARR-seq mESC enhancer starr_21377 Neighboring gene STARR-positive B cell enhancer ABC_E10497 Neighboring gene predicted gene 15634 Neighboring gene cilia and flagella associated protein 97 Neighboring gene STARR-positive B cell enhancer ABC_E10498 Neighboring gene solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus. Takemura S, et al. Neurosci Lett, 2020 May 14. PMID 32156614
  2. Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking. Takemura S, et al. Brain Struct Funct, 2020 Dec. PMID 32955616
  3. Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway. Tanaka T, et al. Nat Immunol, 2023 Mar. PMID 36703006, Free PMC Article
  4. SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Hao X, et al. Cell Signal, 2011 May. PMID 21266196
  5. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking.
    Title: Neural expression of sorting nexin 25 and its regulation of tyrosine receptor kinase B trafficking.
  2. Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus.
    Title: Circadian rhythms of sorting nexin 25 in the mouse suprachiasmatic nucleus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables type I transforming growth factor beta receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sorting nexin-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372342.1 → NP_001359271.1  sorting nexin-25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC114558
    Consensus CDS
    CCDS90394.1
    UniProtKB/TrEMBL
    E9Q1K0
    Related
    ENSMUSP00000106007.3, ENSMUST00000110378.9
    Conserved Domains (5) summary
    cd06878
    Location:648 → 770
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    pfam02194
    Location:148 → 303
    PXA; PXA domain
    pfam08628
    Location:847 → 950
    Nexin_C; Sorting nexin C terminal
    pfam12761
    Location:558 → 645
    End3; Actin cytoskeleton-regulatory complex protein END3
    cl02565
    Location:437 → 545
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_001372343.1 → NP_001359272.1  sorting nexin-25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC114558
    Conserved Domains (5) summary
    cd06878
    Location:648 → 770
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    pfam02194
    Location:148 → 303
    PXA; PXA domain
    pfam08628
    Location:845 → 948
    Nexin_C; Sorting nexin C terminal
    pfam12761
    Location:558 → 645
    End3; Actin cytoskeleton-regulatory complex protein END3
    cl02565
    Location:437 → 545
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. NM_207213.3 → NP_997096.2  sorting nexin-25 isoform 3

    See identical proteins and their annotated locations for NP_997096.2

    Status: VALIDATED

    Source sequence(s)
    AC114558
    Consensus CDS
    CCDS22287.2
    UniProtKB/Swiss-Prot
    E9QMG5, Q3ZT31, Q6PGF1
    Related
    ENSMUSP00000035785.9, ENSMUST00000041582.15
    Conserved Domains (4) summary
    cd06878
    Location:502 → 624
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    pfam02194
    Location:2 → 157
    PXA; PXA domain
    pfam08628
    Location:701 → 804
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:291 → 399
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    46486298..46605535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153706.1 → XP_036009599.1  sorting nexin-25 isoform X1

    UniProtKB/TrEMBL
    Q7TQF4
    Conserved Domains (3) summary
    cd06878
    Location:348 → 470
    PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
    pfam08628
    Location:547 → 650
    Nexin_C; Sorting nexin C terminal
    cl02565
    Location:137 → 245
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RNA

  1. XR_004934742.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3ZT31.3 GenPept UniProtKB/Swiss-Prot:Q3ZT31

Gene LinkOut

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