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Enkd1 enkurin domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 102124, updated on 21-Apr-2024

Summary

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Official Symbol
Enkd1provided by MGI
Official Full Name
enkurin domain containing 1provided by MGI
Primary source
MGI:MGI:2142593
See related
Ensembl:ENSMUSG00000013155 AllianceGenome:MGI:2142593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130303B06Rik
Summary
Located in ciliary base. Is expressed in several structures, including adrenal gland; brain ventricular layer; ileum; male reproductive gland or organ; and sensory organ. Orthologous to human ENKD1 (enkurin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 33.5), CNS E11.5 (RPKM 14.3) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 53.04 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106430281..106435358, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105703649..105708221, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene capping protein regulator and myosin 1 linker 2 Neighboring gene STARR-positive B cell enhancer ABC_E3798 Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6678 Neighboring gene par-6 family cell polarity regulator alpha Neighboring gene adrenocortical dysplasia Neighboring gene glucose-fructose oxidoreductase domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E8850 Neighboring gene RAN binding protein 10 Neighboring gene STARR-positive B cell enhancer ABC_E2272 Neighboring gene translin-associated factor X (Tsnax) interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes. Zhong T, et al. Cell Death Differ, 2022 Sep. PMID 35197565, Free PMC Article
  2. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. Song T, et al. EMBO Rep, 2022 May 4. PMID 35301795, Free PMC Article
  3. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Sigg MA, et al. Dev Cell, 2017 Dec 18. PMID 29257953, Free PMC Article
  4. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  5. Tissue expression patterns identify mouse cilia genes. McClintock TS, et al. Physiol Genomics, 2008 Jan 17. PMID 17971504

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes.
    Title: ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes.
  2. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
    Title: ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
  3. E130303B06Rik is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
    Title: Tissue expression patterns identify mouse cilia genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
  
involved_in motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in 9+0 non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enkurin domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198299.2 → NP_938041.1  enkurin domain-containing protein 1

    See identical proteins and their annotated locations for NP_938041.1

    Status: VALIDATED

    Source sequence(s)
    AC152826
    Consensus CDS
    CCDS22610.1
    UniProtKB/Swiss-Prot
    Q7TSV9
    Related
    ENSMUSP00000013299.10, ENSMUST00000013299.11
    Conserved Domains (1) summary
    pfam13864
    Location:243 → 337
    Enkurin; Calmodulin-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106430281..106435358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530544.2 → XP_006530607.1  enkurin domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006530607.1

    UniProtKB/Swiss-Prot
    Q7TSV9
    Conserved Domains (1) summary
    pfam13864
    Location:243 → 337
    Enkurin; Calmodulin-binding

  2. XM_036153705.1 → XP_036009598.1  enkurin domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q7TSV9
    Conserved Domains (1) summary
    pfam13864
    Location:243 → 337
    Enkurin; Calmodulin-binding

  3. XM_006530543.2 → XP_006530606.1  enkurin domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006530606.1

    UniProtKB/Swiss-Prot
    Q7TSV9
    Related
    ENSMUST00000212716.2
    Conserved Domains (1) summary
    pfam13864
    Location:243 → 337
    Enkurin; Calmodulin-binding

RNA

  1. XR_387725.2 RNA Sequence

  2. XR_004934741.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSV9.1 GenPept UniProtKB/Swiss-Prot:Q7TSV9

Gene LinkOut

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