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Psme3ip1 proteasome activator subunit 3 interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 102122, updated on 5-Mar-2024

Summary

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Official Symbol
Psme3ip1provided by MGI
Official Full Name
proteasome activator subunit 3 interacting protein 1provided by MGI
Primary source
MGI:MGI:1919637
See related
Ensembl:ENSMUSG00000031774 AllianceGenome:MGI:1919637
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nip30; Fam192a; 1700001O11Rik; 2310065K24Rik
Summary
Predicted to be involved in negative regulation of proteasomal protein catabolic process and negative regulation of protein binding activity. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; nasal cavity epithelium; submandibular gland primordium; thymus primordium; and tooth. Orthologous to human PSME3IP1 (proteasome activator subunit 3 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 21.0), CNS E14 (RPKM 19.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Psme3ip1 in Genome Data Viewer
Location:
8 C5; 8 46.58 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95301568..95328483, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94574940..94601962, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NLR family, CARD domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_22357 Neighboring gene predicted gene, 51584 Neighboring gene microRNA 7072 Neighboring gene copine II Neighboring gene STARR-seq mESC enhancer starr_22358 Neighboring gene predicted gene, 38555 Neighboring gene STARR-seq mESC enhancer starr_22359 Neighboring gene STARR-positive B cell enhancer mm9_chr8:97125541-97125842 Neighboring gene predicted gene, 57522 Neighboring gene ring finger and SPRY domain containing 1 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8257 Neighboring gene ADP-ribosylation factor-like 2 binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Gao X, et al. Nat Commun, 2020 Aug 6. PMID 32764536, Free PMC Article
  2. Isolation, expression analysis and characterization of NEFA-interacting nuclear protein 30 and RING finger and SPRY domain containing 1 in skeletal muscle. Waddell DS, et al. Gene, 2016 Jan 15. PMID 26497270
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The REGgamma inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.
    Title: The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.
  2. Nip30 is expressed in skeletal muscle.Nip30 and Rspry1 common promoter region contains a conserved E-box element. Nip30 localizes to the nucleus.
    Title: Isolation, expression analysis and characterization of NEFA-interacting nuclear protein 30 and RING finger and SPRY domain containing 1 in skeletal muscle.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PSME3-interacting protein
Names
NEFA-interacting nuclear protein NIP30
PA28G-interacting protein
family with sequence similarity 192, member A
protein FAM192A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363456.1 → NP_001350385.1  PSME3-interacting protein isoform a

    Status: VALIDATED

    Source sequence(s)
    AC102358
    Consensus CDS
    CCDS40439.1
    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  2. NM_001363457.1 → NP_001350386.1  PSME3-interacting protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC102358
    UniProtKB/TrEMBL
    A0A1D5RLU2
    Related
    ENSMUSP00000148506.2, ENSMUST00000212791.2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  3. NM_028221.4 → NP_082497.2  PSME3-interacting protein isoform a

    See identical proteins and their annotated locations for NP_082497.2

    Status: VALIDATED

    Source sequence(s)
    AK050704, BC016088, BY245102
    Consensus CDS
    CCDS40439.1
    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Related
    ENSMUSP00000034226.7, ENSMUST00000034226.8
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

RNA

  1. NR_156692.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC102358

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95301568..95328483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530540.4 → XP_006530603.1  PSME3-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006530603.1

    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  2. XM_006530541.4 → XP_006530604.1  PSME3-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006530604.1

    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  3. XM_011248256.4 → XP_011246558.1  PSME3-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_011246558.1

    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  4. XM_036153704.1 → XP_036009597.1  PSME3-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  5. XM_036153703.1 → XP_036009596.1  PSME3-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30

  6. XM_006530542.4 → XP_006530605.1  PSME3-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006530605.1

    UniProtKB/Swiss-Prot
    Q3U9X3, Q8R0C9, Q91WE2
    Conserved Domains (1) summary
    pfam10187
    Location:15 → 98
    Nefa_Nip30_N; N-terminal domain of NEFA-interacting nuclear protein NIP30
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WE2.1 GenPept UniProtKB/Swiss-Prot:Q91WE2

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