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FLOT1 flotillin 1 [ Homo sapiens (human) ]

Gene ID: 10211, updated on 11-Apr-2024

Summary

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Official Symbol
FLOT1provided by HGNC
Official Full Name
flotillin 1provided by HGNC
Primary source
HGNC:HGNC:3757
See related
Ensembl:ENSG00000137312 MIM:606998; AllianceGenome:HGNC:3757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in adrenal (RPKM 66.3), heart (RPKM 56.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.33
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30727709..30742687, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30591911..30606890, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30695486..30710464, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mediator of DNA damage checkpoint 1 Neighboring gene MDC1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30683707-30684454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30685203-30685950 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30687755-30688653 Neighboring gene tubulin beta class I Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30698119-30698743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30709349-30710229 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:30711111-30711991 Neighboring gene IER3 antisense RNA 1 Neighboring gene immediate early response 3 Neighboring gene RNA, 7SL, cytoplasmic 353, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis. Mao S, et al. Ann Hematol, 2023 Mar. PMID 36697954
  2. Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation. Jin H, et al. Int J Cancer, 2023 May 1. PMID 36691829
  3. Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment. Wang R, et al. J Cell Mol Med, 2023 Feb. PMID 36647700, Free PMC Article
  4. Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail. Huang Y, et al. PeerJ, 2022. PMID 35990908, Free PMC Article
  5. Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways. Wei J, et al. Eur J Pharmacol, 2022 Feb 5. PMID 34774850

See all (209) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.
    Title: Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.
  2. FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.
    Title: FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.
  3. The roles of FLOT1 in human diseases (Review).
    Title: The roles of FLOT1 in human diseases (Review).
  4. EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
    Title: EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.
  5. FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis.
    Title: FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis.
  6. Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.
    Title: Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.
  7. Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment.
    Title: Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment.
  8. Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail.
    Title: Flotillin-1 promotes EMT of gastric cancer via stabilizing Snail.
  9. Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways.
    Title: Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways.
  10. Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression.
    Title: Long non-coding RNA A1BG-AS1 promotes tumorigenesis in breast cancer by sponging microRNA-485-5p and consequently increasing expression of FLOT1 expression.
Submit: New GeneRIF Correction See all GeneRIFs (80)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic predictors of medically refractory ulcerative colitis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Immunoblot of sucrose fractions to lipid raft marker Flotillin-1 and non-lipid raft marker TfR shows that HIV-1 Gag and Env interact with both Flotillin-1 and TfR in cells PubMed
env HIV-1 gp160 is identified to have a physical interaction with flotillin 1 (FLOT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with flotillin 1 (FLOT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Immunoblot of sucrose fractions to lipid raft marker Flotillin-1 and non-lipid raft marker TfR shows that HIV-1 Gag and Env interact with both Flotillin-1 and TfR in cells PubMed
Tat tat HIV-1 Tat co-localizes with APP and promotes localization of APP to lipid rafts with flotillin-1 in HIV-1 infected U-87 MG cells PubMed
Vpu vpu HIV-1 Vpu predominantly co-localizes to the detergent-soluble fractions with a non-raft protein TfR and partially partitions to the detergent-resistant membrane fractions with a raft protein flotillin 1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dsRNA transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane raft assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_positive_effect plasma membrane raft organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of synaptic transmission, dopaminergic ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of toll-like receptor 3 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein kinase C signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neurotransmitter uptake IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in GABA-ergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in caveola TAS
Traceable Author Statement
more info
 PubMed 
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
part_of flotillin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of flotillin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosomal membrane HDA PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
located_in uropod IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
flotillin-1
Names
integral membrane component of caveolae

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318875.2 → NP_001305804.1  flotillin-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AF117234, AK301291, HY101236
    UniProtKB/TrEMBL
    Q6IB58
    Conserved Domains (2) summary
    cd03399
    Location:30 → 127
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl19107
    Location:193 → 299
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. NM_005803.4 → NP_005794.1  flotillin-1 isoform 1

    See identical proteins and their annotated locations for NP_005794.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF089750, AF117234, HY101236
    Consensus CDS
    CCDS4688.1
    UniProtKB/Swiss-Prot
    B4DVY7, O75955, Q969J8, Q9UHW1, Q9UNV8
    UniProtKB/TrEMBL
    Q5ST80, Q6IB58
    Related
    ENSP00000365569.3, ENST00000376389.8
    Conserved Domains (2) summary
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:4 → 419
    Flot; Flotillin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30727709..30742687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714947.4 → XP_006715010.1  flotillin-1 isoform X4

    See identical proteins and their annotated locations for XP_006715010.1

    UniProtKB/TrEMBL
    A0A140T9R1
    Conserved Domains (3) summary
    smart00244
    Location:31 → 213
    PHB; prohibitin homologues
    cd03399
    Location:18 → 122
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl19107
    Location:188 → 294
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

  2. XM_017010158.2 → XP_016865647.1  flotillin-1 isoform X3

    UniProtKB/TrEMBL
    A0A140T9R1

  3. XM_047418064.1 → XP_047274020.1  flotillin-1 isoform X4

  4. XM_017010157.2 → XP_016865646.1  flotillin-1 isoform X2

    UniProtKB/TrEMBL
    Q6IB58

  5. XM_005248780.4 → XP_005248837.1  flotillin-1 isoform X1

    See identical proteins and their annotated locations for XP_005248837.1

    UniProtKB/Swiss-Prot
    B4DVY7, O75955, Q969J8, Q9UHW1, Q9UNV8
    UniProtKB/TrEMBL
    Q5ST80, Q6IB58
    Conserved Domains (2) summary
    cd03399
    Location:30 → 175
    SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl25773
    Location:4 → 419
    Flot; Flotillin

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2057212..2060006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2207446..2222427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329721.1 → XP_054185696.1  flotillin-1 isoform X4

  2. XM_054329720.1 → XP_054185695.1  flotillin-1 isoform X3

  3. XM_054329719.1 → XP_054185694.1  flotillin-1 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    1983559..1998538 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330217.1 → XP_054186192.1  flotillin-1 isoform X4

  2. XM_054330216.1 → XP_054186191.1  flotillin-1 isoform X3

  3. XM_054330215.1 → XP_054186190.1  flotillin-1 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    2037960..2052938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    2071784..2085411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    1982822..1997797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054330989.1 → XP_054186964.1  flotillin-1 isoform X4

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

    Range
    2028495..2043483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054331272.1 → XP_054187247.1  flotillin-1 isoform X4

  2. XM_054331271.1 → XP_054187246.1  flotillin-1 isoform X3

  3. XM_054331270.1 → XP_054187245.1  flotillin-1 isoform X2

  4. XM_054331273.1 → XP_054187248.1  flotillin-1 isoform X4

  5. XM_054331269.1 → XP_054187244.1  flotillin-1 isoform X1

    UniProtKB/Swiss-Prot
    B4DVY7, O75955, Q969J8, Q9UHW1, Q9UNV8
    UniProtKB/TrEMBL
    Q5ST80

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30591911..30606890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354005.1 → XP_054209980.1  flotillin-1 isoform X4

  2. XM_054354004.1 → XP_054209979.1  flotillin-1 isoform X3

  3. XM_054354003.1 → XP_054209978.1  flotillin-1 isoform X2

  4. XM_054354006.1 → XP_054209981.1  flotillin-1 isoform X4

  5. XM_054354002.1 → XP_054209977.1  flotillin-1 isoform X1

    UniProtKB/Swiss-Prot
    B4DVY7, O75955, Q969J8, Q9UHW1, Q9UNV8
    UniProtKB/TrEMBL
    Q5ST80
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75955.3 GenPept UniProtKB/Swiss-Prot:O75955

Gene LinkOut

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