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Phkb phosphorylase kinase beta [ Mus musculus (house mouse) ]

Gene ID: 102093, updated on 5-Mar-2024

Summary

Official Symbol
Phkbprovided by MGI
Official Full Name
phosphorylase kinase betaprovided by MGI
Primary source
MGI:MGI:97578
See related
Ensembl:ENSMUSG00000036879 AllianceGenome:MGI:97578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calmodulin binding activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in plasma membrane. Predicted to be part of phosphorylase kinase complex. Is expressed in colon; hindgut; and primitive hindgut. Human ortholog(s) of this gene implicated in glycogen storage disease IXb. Orthologous to human PHKB (phosphorylase kinase regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 6.6), limb E14.5 (RPKM 4.8) and 28 other tissues See more
Orthologs
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Genomic context

Location:
8 C3; 8 41.61 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86567489..86790883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85840853..86064251)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39214 Neighboring gene integrin alpha FG-GAP repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_22171 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E, pseudogene 1 Neighboring gene potassium channel tetramerisation domain containing 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22173 Neighboring gene STARR-seq mESC enhancer starr_22174 Neighboring gene kallikrein related-peptidase 7 (chymotryptic, stratum corneum) pseudogene Neighboring gene STARR-seq mESC enhancer starr_22175 Neighboring gene STARR-seq mESC enhancer starr_22176 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene splicing factor 3a, subunit 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC62514

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of phosphorylase kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphorylase kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphorylase b kinase regulatory subunit beta
NP_001351340.1
NP_001351341.1
NP_001390846.1
NP_001390847.1
NP_001390848.1
NP_001390849.1
NP_001390850.1
NP_955517.1
XP_006530596.1
XP_006530600.1
XP_036009591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364411.2NP_001351340.1  phosphorylase b kinase regulatory subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
    Conserved Domains (1) summary
    cl25463
    Location:2290
    Glyco_hydro_15; Glycosyl hydrolases family 15
  2. NM_001364412.2NP_001351341.1  phosphorylase b kinase regulatory subunit beta isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
    Conserved Domains (1) summary
    cl25463
    Location:49349
    Glyco_hydro_15; Glycosyl hydrolases family 15
  3. NM_001403917.1NP_001390846.1  phosphorylase b kinase regulatory subunit beta isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
    UniProtKB/Swiss-Prot
    Q7TSH2
  4. NM_001403918.1NP_001390847.1  phosphorylase b kinase regulatory subunit beta isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
    UniProtKB/Swiss-Prot
    Q7TSH2
  5. NM_001403919.1NP_001390848.1  phosphorylase b kinase regulatory subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
  6. NM_001403920.1NP_001390849.1  phosphorylase b kinase regulatory subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
  7. NM_001403921.1NP_001390850.1  phosphorylase b kinase regulatory subunit beta isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
  8. NM_199446.3NP_955517.1  phosphorylase b kinase regulatory subunit beta isoform 1

    See identical proteins and their annotated locations for NP_955517.1

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830
    Consensus CDS
    CCDS22501.1
    UniProtKB/Swiss-Prot
    Q7TSH2
    Related
    ENSMUSP00000050788.8, ENSMUST00000053771.14
    Conserved Domains (1) summary
    cl25463
    Location:41462
    Glyco_hydro_15; Glycosyl hydrolases family 15

RNA

  1. NR_175780.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC116323, AC117185, AC122830

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    86567489..86790883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530533.5XP_006530596.1  phosphorylase b kinase regulatory subunit beta isoform X2

    See identical proteins and their annotated locations for XP_006530596.1

    UniProtKB/Swiss-Prot
    Q7TSH2
    Conserved Domains (1) summary
    cl25463
    Location:41462
    Glyco_hydro_15; Glycosyl hydrolases family 15
  2. XM_036153698.1XP_036009591.1  phosphorylase b kinase regulatory subunit beta isoform X3

    Conserved Domains (1) summary
    pfam00723
    Location:41462
    Glyco_hydro_15; Glycosyl hydrolases family 15
  3. XM_006530537.5XP_006530600.1  phosphorylase b kinase regulatory subunit beta isoform X4

    Conserved Domains (1) summary
    cl25463
    Location:519646
    Glyco_hydro_15; Glycosyl hydrolases family 15

RNA

  1. XR_001778385.3 RNA Sequence

  2. XR_878767.4 RNA Sequence

  3. XR_001778386.2 RNA Sequence