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Ces2a carboxylesterase 2A [ Mus musculus (house mouse) ]

Gene ID: 102022, updated on 11-Apr-2024

Summary

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Official Symbol
Ces2aprovided by MGI
Official Full Name
carboxylesterase 2Aprovided by MGI
Primary source
MGI:MGI:2142491
See related
Ensembl:ENSMUSG00000055730 AllianceGenome:MGI:2142491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces6; 9130231C15Rik
Summary
Enables carboxylic ester hydrolase activity. Acts upstream of or within protein glycosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Orthologous to human CES2 (carboxylesterase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 135.2), duodenum adult (RPKM 127.9) and 5 other tissues See more
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Genomic context

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See Ces2a in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105460635..105468266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104734003..104741634)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2A pseudogene Neighboring gene carboxylesterase 2E pseudogene Neighboring gene carboxylesterase 2 pseudogene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene RIKEN cDNA 4932416K20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism. Chalhoub G, et al. Mol Metab, 2023 Jun. PMID 37059417, Free PMC Article
  2. Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes. Stok JE, et al. J Biol Chem, 2004 Jul 9. PMID 15123619
  3. Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. Theodorou V, et al. Oncogene, 2004 Aug 12. PMID 15208658
  4. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  5. Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Suzuki T, et al. Development, 2019 Feb 15. PMID 30733279, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables trans-permethrin hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
pyrethroid hydrolase Ces2a
Names
carboxylesterase 6
carboxylic ester hydrolase 2A
NP_001177259.1
NP_598721.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190330.1 → NP_001177259.1  pyrethroid hydrolase Ces2a isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK078953, AK165784, BY088529, BY458169
    Consensus CDS
    CCDS52650.1
    UniProtKB/Swiss-Prot
    Q8QZR3
    Related
    ENSMUSP00000127346.3, ENSMUST00000164182.3
    Conserved Domains (2) summary
    COG0657
    Location:127 → 230
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:30 → 504
    COesterase; Carboxylesterase family

  2. NM_133960.5 → NP_598721.1  pyrethroid hydrolase Ces2a isoform 1 precursor

    See identical proteins and their annotated locations for NP_598721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK078953, BY088529, BY458169
    Consensus CDS
    CCDS22585.1
    UniProtKB/Swiss-Prot
    E9Q3D0, Q3TMR2, Q8QZR3
    Related
    ENSMUSP00000034346.8, ENSMUST00000034346.15
    Conserved Domains (2) summary
    COG0657
    Location:127 → 230
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:30 → 537
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105460635..105468266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZR3.1 GenPept UniProtKB/Swiss-Prot:Q8QZR3

Gene LinkOut

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