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Champ1 chromosome alignment maintaining phosphoprotein 1 [ Mus musculus (house mouse) ]

Gene ID: 101994, updated on 5-Mar-2024

Summary

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Official Symbol
Champ1provided by MGI
Official Full Name
chromosome alignment maintaining phosphoprotein 1provided by MGI
Primary source
MGI:MGI:1196398
See related
Ensembl:ENSMUSG00000047710 AllianceGenome:MGI:1196398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp828; Znf828; mKIAA1802; D8Ertd457e; D8Ertd569e
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in attachment of spindle microtubules to kinetochore and protein localization to organelle. Predicted to be located in Flemming body; kinetochore; and nuclear body. Predicted to be active in nucleoplasm and spindle. Is expressed in genitourinary system and liver. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 40. Orthologous to human CHAMP1 (chromosome alignment maintaining phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 12.3), CNS E14 (RPKM 11.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 6.4 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13919699..13931637)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13869641..13881639)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 2-like 2A Neighboring gene predicted gene, 53400 Neighboring gene predicted gene, 24698 Neighboring gene coordinator of PRMT5, differentiation stimulator Neighboring gene interferon induced transmembrane protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Zhou J, et al. Proc Natl Acad Sci U S A, 2022 Jan 25. PMID 35074918, Free PMC Article
  2. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
  3. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
  4. Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Samudyata, et al. Exp Cell Res, 2019 Aug 1. PMID 31077711, Free PMC Article
  5. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to kinetochore ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to microtubule ISO
Inferred from Sequence Orthology
more info
  
involved_in sister chromatid biorientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sister chromatid biorientation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
chromosome alignment-maintaining phosphoprotein 1
Names
zinc finger protein 828

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363455.2 → NP_001350384.1  chromosome alignment-maintaining phosphoprotein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22116.1
    UniProtKB/Swiss-Prot
    Q3UZ85, Q6ZPI1, Q8K327
    Related
    ENSMUSP00000120117.3, ENSMUST00000128557.3
    Conserved Domains (2) summary
    sd00017
    Location:730 → 750
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:109 → 466
    Atrophin-1; Atrophin-1 family

  2. NM_181854.3 → NP_862902.1  chromosome alignment-maintaining phosphoprotein 1

    See identical proteins and their annotated locations for NP_862902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC139186
    Consensus CDS
    CCDS22116.1
    UniProtKB/Swiss-Prot
    Q3UZ85, Q6ZPI1, Q8K327
    Related
    ENSMUSP00000057270.8, ENSMUST00000051870.8
    Conserved Domains (2) summary
    sd00017
    Location:730 → 750
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl26464
    Location:109 → 466
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13919699..13931637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K327.1 GenPept UniProtKB/Swiss-Prot:Q8K327

Gene LinkOut

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