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Sf3b3 splicing factor 3b, subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 101943, updated on 5-Mar-2024

Summary

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Official Symbol
Sf3b3provided by MGI
Official Full Name
splicing factor 3b, subunit 3provided by MGI
Primary source
MGI:MGI:1289341
See related
Ensembl:ENSMUSG00000033732 AllianceGenome:MGI:1289341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RSE1; SAP130; SF3b130; mKIAA0017; D8Ertd633e; 1810061H24Rik; 5730409A01Rik
Summary
Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of protein catabolic process. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of U2 snRNP and spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 30.3), limb E14.5 (RPKM 23.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.73 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111537123..111573578, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110810491..110846806, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22681 Neighboring gene interleukin 34 Neighboring gene predicted gene 15894 Neighboring gene predicted gene, 39250 Neighboring gene STARR-seq mESC enhancer starr_22683 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene predicted gene, 22193 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene fucose kinase Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 26132

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
  2. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
  3. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Zhao Y, et al. Mol Cell, 2008 Jan 18. PMID 18206972
  4. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. Teachenor R, et al. Mol Cell Biol, 2012 May. PMID 22354994, Free PMC Article
  5. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.
    Title: Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of U12-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
splicing factor 3B subunit 3
Names
SAP 130
pre-mRNA-splicing factor SF3b 130 kDa subunit
spliceosome-associated protein 130

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133953.2 → NP_598714.1  splicing factor 3B subunit 3

    See identical proteins and their annotated locations for NP_598714.1

    Status: VALIDATED

    Source sequence(s)
    AK128988, BC042580, BY126146
    Consensus CDS
    CCDS22665.1
    UniProtKB/Swiss-Prot
    Q3UGI3, Q6ZQL0, Q8BUD9, Q8K2J8, Q921M3
    UniProtKB/TrEMBL
    B2RSV4
    Related
    ENSMUSP00000045073.6, ENSMUST00000042012.7
    Conserved Domains (2) summary
    pfam03178
    Location:863 → 1182
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:76 → 592
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    111537123..111573578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530518.5 → XP_006530581.1  splicing factor 3B subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_006530581.1

    UniProtKB/Swiss-Prot
    Q3UGI3, Q6ZQL0, Q8BUD9, Q8K2J8, Q921M3
    UniProtKB/TrEMBL
    B2RSV4
    Conserved Domains (2) summary
    pfam03178
    Location:863 → 1182
    CPSF_A; CPSF A subunit region
    pfam10433
    Location:76 → 592
    MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

  2. XM_030243208.2 → XP_030099068.1  splicing factor 3B subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam03178
    Location:296 → 615
    CPSF_A; CPSF A subunit region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921M3.1 GenPept UniProtKB/Swiss-Prot:Q921M3

Gene LinkOut

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